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By Anna Riegel Hello Everyone, and anyone!
Rachel A Lindor, James Homme
A 9-year-old girl presented with knee pain and inability to extend her leg after landing on her flexed right knee while jumping on a trampoline. Physical examination revealed superior displacement of the patella (Panel A), and a radiograph showed a fracture of the patella at the inferior pole..
December 15, 2016: New England Journal of Medicine
Judy A Streit, Eiyu Matsumoto
A previously healthy 60-year-old woman presented with a 2-to-3-day history of fevers, chills, myalgias, headache, and two pruritic areas on her back. She had returned 3 days earlier from a 2-week trip to Botswana and Zimbabwe that had included canoeing and camping. She had received vaccines before..
December 15, 2016: New England Journal of Medicine
Timothy M Uyeki, Aneesh K Mehta, Richard T Davey, Allison M Liddell, Timo Wolf, Pauline Vetter, Stefan Schmiedel, Thomas Grünewald, Michael Jacobs, Jose R Arribas, Laura Evans, Angela L Hewlett, Arne B Brantsaeter, Giuseppe Ippolito, Christophe Rapp, Andy I M Hoepelman, Julie Gutman
BACKGROUND: Available data on the characteristics of patients with Ebola virus disease (EVD) and clinical management of EVD in settings outside West Africa, as well as the complications observed in those patients, are limited. METHODS: We reviewed available clinical, laboratory, and virologic data from all patients with laboratory-confirmed Ebola virus infection who received care in U.S. and European hospitals from August 2014 through December 2015. RESULTS: A total of 27 patients (median age, 36 years [range, 25 to 75]) with EVD received care; 19 patients (70%) were male, 9 of 26 patients (35%) had coexisting conditions, and 22 (81%) were health care personnel...
February 18, 2016: New England Journal of Medicine
Claudia Bernárdez, David Saceda-Corralo
A 52-year-old woman presented with an erythematous and tender abdominal lesion; examination revealed a warm, indurated plaque with extension toward her left breast (Panel A). A 43-year-old man presented with a similar tender abdominal lesion; on examination, an erythematous, warm plaque with small..
September 29, 2016: New England Journal of Medicine
Alexandre Nuzzo, Olivier Corcos
A 60-year-old man presented with abdominal pain and hypotension. He had recently had thrombosis of the superior mesenteric artery, which required extensive resection of the distal jejunum and ileum. His serum lactate level was 2.6 mmol per liter (normal range, 0.5 to 2.2), and his creatinine level..
October 13, 2016: New England Journal of Medicine
Adam L Holtzman, Kathryn Hitchcock
A 68-year-old man presented with a mass on the left side of his neck (Panel A). He had no history of tobacco use and drank one or two alcoholic drinks per week. A biopsy of the mass was performed, and histopathological examination revealed squamous-cell carcinoma that tested positive for human..
September 29, 2016: New England Journal of Medicine
Pradip Dashraath, Harvard Z Lin
A 38-year-old woman who had undergone three low-segment cesarean sections was admitted to the hospital in labor at 36 weeks of gestation. Antenatal ultrasonography suggested placenta accreta (Panel A), with the appearance of irregular vascular spaces (asterisk) and loss of retroplacental hypoechoic..
October 6, 2016: New England Journal of Medicine
Kyungmin Huh, Jeong Hoon Choi
A 21-year-old man presented with a 2-week history of itching in his left eye. He reported "seeing worms" in his eye. He underwent thorough irrigation of the conjunctival sac and lacrimal duct, during which three worms were removed (video and Panel A). The worms were white, slender, and filiform..
October 6, 2016: New England Journal of Medicine
Tania Afonso, Romeu Pires
A 70-year-old man presented with a 2-day history of facial edema, rash with vesicles, pustules, and crusts along the left lower jaw, and plaque that had covered the anterior two thirds of the left half of his tongue. He reported that he had had pain in the lower half of the left side of his face,..
July 28, 2016: New England Journal of Medicine
Bartosz Hudzik, Mariusz Gąsior
A 46-year-old otherwise healthy man presented with a 1-year history of occasional dysphagia to solid foods that was not accompanied by weight loss. The results of a physical examination were unremarkable. A barium-swallow examination revealed posterior oblique indentation of the proximal esophagus (..
July 28, 2016: New England Journal of Medicine
Anne Gulland
No abstract text is available yet for this article.
June 29, 2016: BMJ: British Medical Journal
Annika Wylie, Amanda E Jones, Alejandro D'Brot, Wan-Jin Lu, Paula Kurtz, John V Moran, Dinesh Rakheja, Kenneth S Chen, Robert E Hammer, Sarah A Comerford, James F Amatruda, John M Abrams
Throughout the animal kingdom, p53 genes govern stress response networks by specifying adaptive transcriptional responses. The human member of this gene family is mutated in most cancers, but precisely how p53 functions to mediate tumor suppression is not well understood. Using Drosophila and zebrafish models, we show that p53 restricts retrotransposon activity and genetically interacts with components of the piRNA (piwi-interacting RNA) pathway. Furthermore, transposon eruptions occurring in the p53(-) germline were incited by meiotic recombination, and transcripts produced from these mobile elements accumulated in the germ plasm...
January 1, 2016: Genes & Development
Marianna Feretzaki, Sarah E Hardison, Floyd L Wormley, Joseph Heitman
Cryptococcus neoformans is a human fungal pathogen that causes lethal infections of the lung and central nervous system in immunocompromised individuals. C. neoformans has a defined bipolar sexual life cycle with a and α mating types. During the sexual cycle, which can occur between cells of opposite mating types (bisexual reproduction) or cells of one mating type (unisexual reproduction), a dimorphic transition from yeast to hyphal growth occurs. Hyphal development and meiosis generate abundant spores that, following inhalation, penetrate deep into the lung to enter the alveoli, germinate, and establish a pulmonary infection growing as budding yeast cells...
2014: PloS One
Wafik Zaky
Pediatric central nervous system primitive neuro-ectodermal brain tumors (CNS-PNETs) are rare tumors with ill-defined biological features. In this issue of Cell, Sturm et al. used state-of-the-art methods to interrogate these tumors' biology. Their integrated molecular analyses led them to propose a new molecular classification, with four new entities identified, that should get oncologists' attention.
February 25, 2016: Cell
M Pompili, M Belvederi Murri, S Patti, M Innamorati, D Lester, P Girardi, M Amore
BACKGROUND: Among the myths that are often cited about suicide is that 'people who talk about killing themselves rarely die by suicide', but the evidence seems to contradict this statement. The aim of this study was to conduct a meta-analysis of studies reporting a prevalence of suicide communication (SC), and to examine the diagnostic accuracy of SC towards suicide in case-control reports. METHOD: Eligible studies had to examine data relative to completed suicides and report the prevalence of SC...
August 2016: Psychological Medicine
Elli Papaemmanuil, Moritz Gerstung, Lars Bullinger, Verena I Gaidzik, Peter Paschka, Nicola D Roberts, Nicola E Potter, Michael Heuser, Felicitas Thol, Niccolo Bolli, Gunes Gundem, Peter Van Loo, Inigo Martincorena, Peter Ganly, Laura Mudie, Stuart McLaren, Sarah O'Meara, Keiran Raine, David R Jones, Jon W Teague, Adam P Butler, Mel F Greaves, Arnold Ganser, Konstanze Döhner, Richard F Schlenk, Hartmut Döhner, Peter J Campbell
BACKGROUND: Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical practice. METHODS: We enrolled a total of 1540 patients in three prospective trials of intensive therapy. Combining driver mutations in 111 cancer genes with cytogenetic and clinical data, we defined AML genomic subgroups and their relevance to clinical outcomes...
June 9, 2016: New England Journal of Medicine
Michael C Dewan, Reid C Thompson, Steven N Kalkanis, Fred G Barker, Constantinos G Hadjipanayis
OBJECTIVE Antiepileptic drugs (AEDs) are often administered prophylactically following brain tumor resection. With conflicting evidence and unestablished guidelines, however, the nature of this practice among tumor surgeons is unknown. METHODS On November 24, 2015, a REDCap (Research Electronic Database Capture) survey was sent to members of the AANS/CNS Section on Tumors to query practice patterns. RESULTS Responses were received from 144 individuals, including 18.8% of board-certified neurosurgeons surveyed (across 86 institutions, 16 countries, and 5 continents)...
June 24, 2016: Journal of Neurosurgery
Kenneth P Wright, Richard K Bogan, James K Wyatt
Nearly 20% of the labor force worldwide, work shifts that include work hours outside 07:00 h to 18:00 h. Shift work is common in many occupations that directly affect the health and safety of others (e.g., protective services, transportation, healthcare), whereas quality of life, health, and safety during shift work and the commute home can affect workers in any field. Increasing evidence indicates that shift-work schedules negatively influence worker physiology, health, and safety. Shift work disrupts circadian sleep and alerting cycles, resulting in disturbed daytime sleep and excessive sleepiness during the work shift...
February 2013: Sleep Medicine Reviews
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