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Pediatría

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By Felipe Cadena Pediatrics Resident
https://www.readbyqxmd.com/read/24756515/lorazepam-vs-diazepam-for-pediatric-status-epilepticus-a-randomized-clinical-trial
#1
RANDOMIZED CONTROLLED TRIAL
James M Chamberlain, Pamela Okada, Maija Holsti, Prashant Mahajan, Kathleen M Brown, Cheryl Vance, Victor Gonzalez, Richard Lichenstein, Rachel Stanley, David C Brousseau, Joseph Grubenhoff, Roger Zemek, David W Johnson, Traci E Clemons, Jill Baren
IMPORTANCE: Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication. OBJECTIVE: To test the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus. DESIGN, SETTING, AND PARTICIPANTS: This double-blind, randomized clinical trial was conducted from March 1, 2008, to March 14, 2012...
April 23, 2014: JAMA: the Journal of the American Medical Association
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