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Vitamin d and FTO

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9 papers 0 to 25 followers
By Clare Dix Dietitian, PhD candidate, researching vitamin D and obesity
Tao Huang, Yan Zheng, Adela Hruby, Donald A Williamson, George A Bray, Yiru Shen, Frank M Sacks, Lu Qi
Background: The melanocortin-4 receptor (MC4R) plays a pivotal role in the regulation of appetite and eating behavior. Variants in the MC4R gene have been related to appetite and obesity. Objective: We aimed to examine whether weight-loss diets modified the effect of the "obesity-predisposing" MC4R genotype on appetite-related measures in a randomized controlled trial. Methods: A total of 811 overweight and obese subjects [25 ≤ body mass index (BMI; kg/m2 ) ≤ 40] aged 30-70 y were included in the 2-y POUNDS Lost (Preventing Overweight Using Novel Dietary Strategies) trial...
March 2017: Journal of Nutrition
Joanna Nowacka-Woszuk, Ewa Pruszynska-Oszmalek, Maciej Szydlowski, Izabela Szczerbal
The fat mass and obesity associated (Fto) and iroquois homeobox 3 (Irx3) genes have been recognised as important obesity-related genes. Studies on the expression of these genes in the fat tissue of human and mouse have produced inconsistent results, while similar data on rat are limited. Environmental factors such as diet, should be considered as potential modulators of gene transcript levels through epigenetic mechanisms including DNA methylation. The aim of this study was to evaluate transcription levels and DNA methylation profiles of rat Fto and Irx3 genes in two white adipose tissue depots in response to high-fat and high-protein diets...
April 30, 2017: Gene
I Labayen, J R Ruiz, I Huybrechts, F B Ortega, L Arenaza, M González-Gross, K Widhalm, D Molnar, Y Manios, S DeHenauw, A Meirhaeghe, L A Moreno
BACKGROUND AND AIMS: The fat mass and obesity associated gene (FTO) has been associated with obesity and dietary intake. The aims were: (i) To assess whether energy and macronutrient intakes were different across the FTOrs9939609 genotypes in adolescents, and (ii) to explore whether dietary fat intake modified the association of the rs9939609 polymorphism with adiposity. METHODS AND RESULTS: The FTOrs9939609 polymorphism was genotyped in 652 adolescents (53% females, 14...
October 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Kathrin Landgraf, Markus Scholz, Peter Kovacs, Wieland Kiess, Antje Körner
BACKGROUND: Genome-wide association studies have identified variants within the FTO (fat mass and obesity associated) locus as the strongest predictors of obesity amongst all obesity-associated gene loci. Recent evidence suggests that variants in FTO directly affect human adipocyte function through targeting IRX3 and IRX5 and thermogenesis regulation. AIM: We addressed the relevance of this proposed FTO-IRX pathway in adipose tissue (AT) of children. RESULTS: Expression of IRX3 was higher in adipocytes compared to SVF...
2016: PloS One
Barbara H Lourenço, Lu Qi, Walter C Willett, Marly A Cardoso
Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in a population-based longitudinal study in the Brazilian Amazon and investigated whether these effects were modified by vitamin D status, an important nutritional factor related to adiposity. At baseline, 1,088 children aged <10 years had complete genotypic and anthropometric data; 796 were followed up over a median 4...
February 2014: Diabetes
Shoaib Afzal, Peter Brøndum-Jacobsen, Stig E Bojesen, Børge G Nordestgaard
BACKGROUND: Low plasma 25-hydroxyvitamin D (25[OH]D) concentration and high BMI have been associated with increased risk of diabetes. We tested the hypotheses that genetic variants associated with low concentrations of 25(OH)D are associated with diabetes, and that the effect on diabetes of genetic variants associated with high BMI is partly mediated through reduced plasma 25(OH)D concentration. METHODS: In this mendelian randomisation study, we genotyped 96 423 white Danes aged 20-100 years from three studies...
April 2014: Lancet Diabetes & Endocrinology
Marcus Bandstein, Bernd Schultes, Barbara Ernst, Martin Thurnheer, Helgi B Schiöth, Christian Benedict
BACKGROUND: A recent study in children demonstrated that the rs9939609 single-nucleotide polymorphism in the fat mass and obesity (FTO) gene influences prospective weight gain, however, only in those who were vitamin D-deficient. If this might also be the case for Roux-en-Y gastric bypass (RYGB), surgery-induced weight loss is however unknown. The objective of this study is to examine if the magnitude of RYGB surgery-induced weight loss after 2 years depends on patients' FTO rs9939609 genotype (i...
November 2015: Obesity Surgery
Reina Armamento-Villareal, Neil Wingkun, Lina E Aguirre, Vibhati Kulkarny, Nicola Napoli, Georgia Colleluori, Clifford Qualls, Dennis T Villareal
OBJECTIVE: Fat mass and obesity-associated (FTO) gene polymorphisms have been reported to be associated with differences in BMI, obesity, and type 2 diabetes. However, previous studies have been predominantly conducted in younger individuals across a spectrum of body weights, whereas little information is available on the older population. We examined the association of FTO gene polymorphisms with cardiometabolic risks among adults who were both obese (BMI≥30 kg/m) and older (age≥65 years)...
December 24, 2015: Pharmacogenetics and Genomics
Rumana J Khan, Pia Riestra, Samson Y Gebreab, James G Wilson, Amadou Gaye, Ruihua Xu, Sharon K Davis
BACKGROUND: The biological actions of vitamin D are mediated through the vitamin D receptor (VDR). Single-nucleotide polymorphisms (SNPs) in the VDR gene have been previously associated with adiposity traits. However, to our knowledge, few studies have included direct measures of adiposity and adipokine concentrations. OBJECTIVE: We examined the association of tagging SNPs in the VDR gene with multiple adiposity measures, including waist circumference (WC), body mass index (BMI), body fat percentage, subcutaneous and visceral adipose tissue (VAT) volume, and serum adipokine (adiponectin and leptin) concentrations in adult African Americans (AAs)...
August 2016: Journal of Nutrition
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