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2 papers 0 to 25 followers Pediatric seizure ED and beyond
Yvonne W Wu, Joseph Sullivan, Sharon S McDaniel, Miriam H Meisler, Eileen M Walsh, Sherian Xu Li, Michael W Kuzniewicz
OBJECTIVE: De novo mutations of the gene sodium channel 1α (SCN1A) are the major cause of Dravet syndrome, an infantile epileptic encephalopathy. US incidence of DS has been estimated at 1 in 40 000, but no US epidemiologic studies have been performed since the advent of genetic testing. METHODS: In a retrospective, population-based cohort of all infants born at Kaiser Permanente Northern California during 2007-2010, we electronically identified patients who received ≥2 seizure diagnoses before age 12 months and who were also prescribed anticonvulsants at 24 months...
November 2015: Pediatrics
Amir A Kimia, Richard G Bachur, Alcy Torres, Marvin B Harper
PURPOSE OF REVIEW: The review describes current evidence on the evaluation of febrile seizures in the acute setting, the need for further outpatient assessment, and predictors regarding long-term outcomes of these patients. RECENT FINDINGS: New evidence has been added in support of limited assessment and intervention: evidence on low utility of lumbar puncture, emergent neuroimaging, and follow-up electroencephalography, as well as low yield for antipyretic prophylaxis and intermittent use of antiepileptic drugs...
June 2015: Current Opinion in Pediatrics
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