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Masaki Futamura, Yael A Leshem, Kim S Thomas, Helen Nankervis, Hywel C Williams, Eric L Simpson
BACKGROUND: Investigators often use global assessments to provide a snapshot of overall disease severity in dermatologic clinical trials. Although easy to perform, the frequency of use and standardization of global assessments in studies of atopic dermatitis (AD) is unclear. OBJECTIVES: We sought to assess the frequency, definitions, and methods of analysis of Investigator Global Assessment in randomized controlled trials of AD. METHODS: We conducted a systematic review using all published randomized controlled trials of AD treatments in the Global Resource of Eczema Trials database (2000-2014)...
February 2016: Journal of the American Academy of Dermatology
Sean McGregor, Michael E Farhangian, Steven R Feldman
INTRODUCTION: Current treatment options for moderate-to-severe atopic dermatitis (AD) are limited and have potentially dangerous side effects. Dupilumab is a novel monoclonal antibody that was recently studied in adult patients with moderate-to-severe AD. Dupilumab inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling and was previously found to be effective in asthma. Considering that both AD and asthma are Th2 cell-mediated inflammatory processes, it is reasonable to suspect that dupilumab would be beneficial in AD...
2015: Expert Opinion on Biological Therapy
Christine Coutanceau, Jean-François Stalder
OBJECTIVE: Self-assessment scores such as the Patient-Oriented Scoring of Atopic Dermatitis (PO-SCORAD) index being recommended by public health authorities for chronic disease management, we aimed at analysing correlations between PO-SCORAD and physician and patient assessment scores of atopic dermatitis (AD) severity and quality of life. METHODS: We perfomed an observational study conducted in 12 European countries in 4,222 atopic patients aged ≥1 month and prescribed Exomega® emollient cream...
2014: Dermatology: International Journal for Clinical and Investigative Dermatology
Yukie Yamaguchi
Extracellular matrix (ECM) is not only involved in the maintenance of normal physiological tissue but also in interactions with other ECM components, tissue remodeling, and modulating immune responses. The skin provides a distinctive environment characterized by rich fibroblasts producing various ECM proteins, epithelial-mesenchymal interactions, and immune responses induced by external stimuli. Recently, periostin-a matricellular protein-has been highlighted for its pivotal functions in the skin. Analysis of periostin null mice has revealed that periostin contributes to collagen fibrillogenesis, collagen cross-linking, and the formation of ECM meshwork via interactions with other ECM components...
June 2014: Allergology International: Official Journal of the Japanese Society of Allergology
K Kou, T Okawa, Y Yamaguchi, J Ono, Y Inoue, M Kohno, S Matsukura, T Kambara, S Ohta, K Izuhara, M Aihara
BACKGROUND: Recent findings indicate that periostin, an extracellular matrix protein induced by T helper 2 cytokines, plays a critical role in the pathogenesis of atopic dermatitis (AD). OBJECTIVES: To determine whether serum periostin level is associated with clinical phenotype in adult patients with AD. METHODS: An enzyme-linked immunosorbent assay was performed to determine serum periostin levels in 257 adult patients with AD, 66 patients with psoriasis vulgaris (PV) as a disease control and 25 healthy controls...
August 2014: British Journal of Dermatology
Lingli Yang, Hiroyuki Murota, Satoshi Serada, Minoru Fujimoto, Akira Kudo, Tetsuji Naka, Ichiro Katayama
Histamine is thought to have a critical role in the synthesis of extracellular matrix in skin and may be involved in tissue remodeling of allergic diseases. Recent studies revealed that periostin, a matricelluar protein, contributed to tissue remodeling; however, a link between periostin and histamine remains unproven. We investigated whether periostin was involved in histamine-induced collagen production. Cultured dermal fibroblasts derived from wild-type (WT) or periostin knockout (PN(-/-)) mice were stimulated with histamine, and then collagen and periostin production was evaluated...
August 2014: Journal of Investigative Dermatology
Jochen Schmitt, Sinéad Langan, Stefanie Deckert, Ake Svensson, Laura von Kobyletzki, Kim Thomas, Phyllis Spuls
BACKGROUND: Clinical signs are a core outcome domain for atopic dermatitis (AD) trials. The current lack of standardization of outcome measures in AD trials hampers evidence-based communication. OBJECTIVE: We sought to provide evidence-based recommendations for the measurement of clinical signs in AD trials and to inform the Harmonising Outcome Measures for Atopic Dermatitis Initiative. METHODS: We conducted a systematic review on measurement properties of outcome measurements for clinical signs of AD...
December 2013: Journal of Allergy and Clinical Immunology
Hiroshi Shiraishi, Miho Masuoka, Shoichiro Ohta, Shoichi Suzuki, Kazuhiko Arima, Kazuto Taniguchi, Shigehisa Aoki, Shuji Toda, Tomohiro Yoshimoto, Naoki Inagaki, Simon J Conway, Yutaka Narisawa, Kenji Izuhara
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease where Th2-type immune responses are dominant. Keratinocytes persistently secrete proinflammatory cytokines and chemokines, amplifying Th2-type responses in AD. We have recently reported that periostin, an extracellular matrix protein induced by Th2 cytokines, plays a critical role in AD. In the present study, we have further investigated the characteristics of our allergen-induced AD model mice and the role of periostin in the pathogenesis of AD...
December 2012: Allergology International: Official Journal of the Japanese Society of Allergology
Marjolein G Willemsen, Rosalinda W C van Valburg, Pauline C Dirven-Meijer, Arnold P Oranje, Johannes C van der Wouden, Heleen Moed
Assessment of the severity of atopic dermatitis (AD) is necessary to evaluate the disease process. This study evaluates and validates the TIS in children with AD presenting in general practice. Independent investigators determined the severity of AD using the TIS and the objective SCORAD. The interobserver agreement for the TIS and SCORAD was calculated, as was the correlation between TIS and SCORAD. The mean time to assess the TIS was less than one minute. A moderate-to-good agreement between the observers was found for the TIS (kappa = 0...
2009: Dermatology Research and Practice
I Angelova-Fischer, A Bauer, U C Hipler, I Petrov, J Kazandjieva, T Bruckner, T Diepgen, N Tsankov, M Williams, T W Fischer, P Elsner, J W Fluhr
BACKGROUND: The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score is a recently developed scale for evaluation of severity of atopic dermatitis, constructed from the assessment of epidermal barrier function, and properties using noninvasive bioengineering methods and computer-assisted estimates of disease extent. The method has been validated for use in infants and children with atopic dermatitis and compared with a referent scoring system. OBJECTIVES: The aim of the present study was to test the validity, reliability and sensitivity of the OSAAD score as an objective tool for the assessment of the severity of atopic dermatitis in adult patients...
October 2005: British Journal of Dermatology
Jeffrey L Sugarman, Joachim W Fluhr, Ashley J Fowler, Thomas Bruckner, Thomas L Diepgen, Mary L Williams
OBJECTIVES: Clinical scores used to assess the severity of atopic dermatitis (AD) rely entirely on subjective criteria to evaluate the severity of lesions and the extent of involvement. The aim of this study was to develop an objective measure of AD severity by measuring stratum corneum (SC) functions and by using computer-assisted estimates of involved body surface areas (BSAs). DESIGN: Barrier function of the SC was assessed by measuring transepidermal water loss, and SC hydration was assessed by measuring capacitance...
November 2003: Archives of Dermatology
(no author information available yet)
BACKGROUND: Assessment methods for atopic dermatitis (AD) are not standardized, and therapeutic studies are difficult to interpret. AIMS: To obtain a consensus on assessment methods in AD and to use a statistical method to develop a composite severity index. METHODS: Consensus definitions were given for items used in the scoring system (extent, intensity, subjective) and illustrated for intensity items. Slides were reviewed to address within- and between-observer variability by a group of 10 trained clinicians, and data were statistically evaluated with a two-way analysis of variance...
1993: Dermatology: International Journal for Clinical and Investigative Dermatology
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