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Oncology

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8 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27664247/management-of-febrile-neutropaenia-esmo-clinical-practice-guidelines
#1
J Klastersky, J de Naurois, K Rolston, B Rapoport, G Maschmeyer, M Aapro, J Herrstedt
No abstract text is available yet for this article.
September 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27070264/reprogramming-cancer-cells-overview-current-progress
#2
Kian Lam Lim, Hoon Koon Teoh, Pei Feng Choong, Hui Xin Teh, Soon Keng Cheong, Tunku Kamarul
INTRODUCTION: Cancer is a disease with genetic and epigenetic origins, and the possible effects of reprogramming cancer cells using the defined sets of transcription factors remain largely uninvestigated. In the handful of publications available so far, findings have shown that reprogramming cancer cells changed the characteristics of the cells to differ from the parental cancer cells. These findings indicated the possibility of utilizing reprogramming technology to create a disease model in the laboratory to be used in studying the molecular pathogenesis or for drug screening of a particular cancer model...
July 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/26276716/reprogramming-cancer-cells-a-novel-approach-for-cancer-therapy-or-a-tool-for-disease-modeling
#3
REVIEW
Açelya Yilmazer, Irene de Lázaro, Hadiseh Taheri
Chromatin dynamics have been the major focus of many physiological and pathological processes over the past 20 years. Epigenetic mechanisms have been shown to be reshaped during both cellular reprogramming and tumorigenesis. For this reason, cancer cell reprogramming can provide a powerful tool to better understand both regenerative and cancer-fate processes, with a potential to develop novel therapeutic approaches. Recent studies showed that cancer cells can be reprogrammed to a pluripotent state by the overexpression of reprogramming transcription factors...
December 1, 2015: Cancer Letters
https://www.readbyqxmd.com/read/27725680/diagnosis-of-cancer-as-an-emergency-a-critical-review-of-current-evidence
#4
REVIEW
Yin Zhou, Gary A Abel, Willie Hamilton, Kathy Pritchard-Jones, Cary P Gross, Fiona M Walter, Cristina Renzi, Sam Johnson, Sean McPhail, Lucy Elliss-Brookes, Georgios Lyratzopoulos
Many patients with cancer are diagnosed through an emergency presentation, which is associated with inferior clinical and patient-reported outcomes compared with those of patients who are diagnosed electively or through screening. Reducing the proportion of patients with cancer who are diagnosed as emergencies is, therefore, desirable; however, the optimal means of achieving this aim are uncertain owing to the involvement of different tumour, patient and health-care factors, often in combination. Most relevant evidence relates to patients with colorectal or lung cancer in a few economically developed countries, and defines emergency presentations contextually (that is, whether patients presented to emergency health-care services and/or received emergency treatment shortly before their diagnosis) as opposed to clinically (whether patients presented with life-threatening manifestations of their cancer)...
October 11, 2016: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/27610560/probing-the-diversity-of-t%C3%A2-cell-dysfunction-in-cancer
#5
COMMENT
Ryan T Sowell, Susan M Kaech
T cell dysfunction in cancer comes in many forms, with two new varieties reported in this issue. Daley et al. find that T cells expressing γδ T cell receptors (TCR) promote pancreatic tumor growth by inhibiting activation of T cells with conventional TCRs. Singer et al. characterize dysfunctional tumor infiltrating lymphocytes to reveal a role for zinc homeostasis in anti-tumor immunity.
September 8, 2016: Cell
https://www.readbyqxmd.com/read/26542545/microbiome-microbes-aid-cancer-drugs
#6
Mitch Leslie
No abstract text is available yet for this article.
November 6, 2015: Science
https://www.readbyqxmd.com/read/27183032/association-of-leisure-time-physical-activity-with-risk-of-26-types-of-cancer-in-1-44-million-adults
#7
Steven C Moore, I-Min Lee, Elisabete Weiderpass, Peter T Campbell, Joshua N Sampson, Cari M Kitahara, Sarah K Keadle, Hannah Arem, Amy Berrington de Gonzalez, Patricia Hartge, Hans-Olov Adami, Cindy K Blair, Kristin B Borch, Eric Boyd, David P Check, Agnès Fournier, Neal D Freedman, Marc Gunter, Mattias Johannson, Kay-Tee Khaw, Martha S Linet, Nicola Orsini, Yikyung Park, Elio Riboli, Kim Robien, Catherine Schairer, Howard Sesso, Michael Spriggs, Roy Van Dusen, Alicja Wolk, Charles E Matthews, Alpa V Patel
IMPORTANCE: Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE: To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary by body size and/or smoking. DESIGN, SETTING, AND PARTICIPANTS: We pooled data from 12 prospective US and European cohorts with self-reported physical activity (baseline, 1987-2004)...
June 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27348695/critical-care-of-patients-with-cancer
#8
Alexander Shimabukuro-Vornhagen, Boris Böll, Matthias Kochanek, Éli Azoulay, Michael S von Bergwelt-Baildon
Answer questions and earn CME/CNE The increasing prevalence of patients living with cancer in conjunction with the rapid progress in cancer therapy will lead to a growing number of patients with cancer who will require intensive care treatment. Fortunately, the development of more effective oncologic therapies, advances in critical care, and improvements in patient selection have led to an increased survival of critically ill patients with cancer. As a consequence, critical care has become an important cornerstone in the continuum of modern cancer care...
June 27, 2016: CA: a Cancer Journal for Clinicians
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