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Carlos A Sánchez-Catasús, Gilles N Stormezand, Peter Jan van Laar, Peter P De Deyn, Mario Alvarez Sánchez, Rudi A J O Dierckx
This review article aims at providing a state-of-the-art review of the role of fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging (FDG-PET) in the prediction of Alzheimer's dementia in subjects suffering mild cognitive impairment (MCI), with a particular focus on the predictive power of FDG-PET compared to structural magnetic resonance imaging (sMRI). We also address perfusion single photon emission computed tomography (SPECT) as a less costly and more accessible alternative to FDG- PET. A search in PubMed was performed, taking into consideration relevant scientific articles published in English within the last five years and limited to human studies...
June 28, 2016: Current Alzheimer Research
Ahsan Rao, Amna Suliman, Sabine Vuik, Paul Aylin, Ara Darzi
INTRODUCTION: Aim of the study was to compare various outcomes of dementia patients with elderly patients without dementia by conducting a systematic review of previous population-based studies. METHODS: The relevant studies were retrieved from search of electronic databases. RESULTS: The pooled data from included 11 studies consisted of outcomes of 1,044,131 dementia patients compared to 9,639,027 elderly patients without dementia. Meta-analysis showed that the mortality in dementia patients was 15...
September 2016: Archives of Gerontology and Geriatrics
Victor I Reus, Laura J Fochtmann, A Evan Eyler, Donald M Hilty, Marcela Horvitz-Lennon, Michael D Jibson, Oscar L Lopez, Jane Mahoney, Jagoda Pasic, Zaldy S Tan, Cheryl D Wills, Richard Rhoads, Joel Yager
No abstract text is available yet for this article.
May 1, 2016: American Journal of Psychiatry
Jennifer S Lin, Elizabeth O'Connor, Rebecca C Rossom, Leslie A Perdue, Elizabeth Eckstrom
BACKGROUND: Earlier identification of cognitive impairment may reduce patient and caregiver morbidity. PURPOSE: To systematically review the diagnostic accuracy of brief cognitive screening instruments and the benefits and harms of pharmacologic and nonpharmacologic interventions for early cognitive impairment. DATA SOURCES: MEDLINE, PsycINFO, and the Cochrane Central Register of Controlled Trials through December 2012; systematic reviews; clinical trial registries; and experts...
November 5, 2013: Annals of Internal Medicine
Daniela Koller, Tammy Hua, Julie P W Bynum
OBJECTIVES: To evaluate frequency of use of two anti-dementia drug classes approved for treatment of symptoms, whether populations most likely to benefit are treated, and correlates of treatment initiation. DESIGN: Nationally representative cohort study. SETTING: Fee-for-service Medicare. PARTICIPANTS: Elderly adults with dementia enrolled in Medicare Parts A, B, and D in 2009 (N = 433,559) and a subset with incident dementia (n = 185,449)...
August 2016: Journal of the American Geriatrics Society
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