L A Renfro, A Grothey, D Kerr, D G Haller, T André, E Van Cutsem, L Saltz, R Labianca, C L Loprinzi, S R Alberts, H Schmoll, C Twelves, G Yothers, D J Sargent
BACKGROUND: Post-treatment survival experience of early colon cancer (CC) patients is well described in the literature, which states that cure is probable for some patients. However, comparisons of treated patients' survival versus that expected from a matched general population (MGP) are limited. PATIENTS AND METHODS: A total of 32 745 patients from 25 randomized adjuvant trials conducted from 1977 to 2012 in 41 countries were pooled. Observed long-term survival of these patients was compared with expected survival matched on sex, age, country, and year, both overall and by stage (II and III), sex, treatment [surgery, 5-fluorouracil (5-FU), 5-FU + oxaliplatin], age (<70 and 70+), enrollment year (pre/post 2000), and recurrence (yes/no)...
May 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology