Jeanne S Mandelblatt, Brent J Small, Gheorghe Luta, Arti Hurria, Heather Jim, Brenna C McDonald, Deena Graham, Xingtao Zhou, Jonathan Clapp, Wanting Zhai, Elizabeth Breen, Judith E Carroll, Neelima Denduluri, Asma Dilawari, Martine Extermann, Claudine Isaacs, Paul B Jacobsen, Lindsay C Kobayashi, Kelly Holohan Nudelman, James Root, Robert A Stern, Danielle Tometich, Raymond Turner, John W VanMeter, Andrew J Saykin, Tim Ahles
PURPOSE: To determine treatment and aging-related effects on longitudinal cognitive function in older breast cancer survivors. METHODS: Newly diagnosed nonmetastatic breast cancer survivors (n = 344) and matched controls without cancer (n = 347) 60 years of age and older without dementia or neurologic disease were recruited between August 2010 and December 2015. Data collection occurred during presystemic treatment/control enrollment and at 12 and 24 months through biospecimens; surveys; self-reported Functional Assessment of Cancer Therapy-Cognitive Function; and neuropsychological tests that measured attention, processing speed, and executive function (APE) and learning and memory (LM)...
October 3, 2018: Journal of Clinical Oncology