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Chemotherapy-induced cognitive impairment

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438 papers 0 to 25 followers This is a collection of topics relating to post-chemotherapy fatigue and attentional, executive, memory, or processing deficits. Also included are papers on cognitive impairments related to other cancer interventions (radiotherapy, surgery, etc.)
Hye-Sang Park, Chang-Ju Kim, Hyo-Bum Kwak, Mi-Hyun No, Jun-Won Heo, Tae-Woon Kim
Although chemotherapy increases the survival rate of patients with various cancers, such treatment can induce acute or long-term cognitive dysfunction a phenomenon known as post-chemotherapy cognitive impairment (PCCI) or "chemobrain." Exercise is known to positively affect brain function. Thus, the present study aimed to determine whether symptoms of chemobrain and disruptions in the neuroplasticity and functioning of hippocampal mitochondria can be prevented or relieved by exercise. Wistar rats were separated into the following groups: control, control plus exercise, chemobrain, and chemobrain plus exercise...
February 22, 2018: Neuropharmacology
Wei Liu, Yin Ting Cheung, Heather M Conklin, Lisa M Jacola, DeoKumar Srivastava, Vikki G Nolan, Hongmei Zhang, James G Gurney, I-Chan Huang, Leslie L Robison, Ching-Hon Pui, Melissa M Hudson, Kevin R Krull
PURPOSE: The purpose of this study was to determine the evolution of neurocognitive problems from therapy completion to long-term follow-up in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. METHODS: We evaluated whether attention problems observed at therapy completion evolve into long-term executive dysfunction in 158 survivors treated on a single institution protocol. Treatment data (high-dose intravenous methotrexate exposure [serum concentration] and triple intrathecal chemotherapy injections) were collected...
February 27, 2018: Journal of Cancer Survivorship: Research and Practice
Terence Ng, Sreemanee Raaj Dorajoo, Yin Ting Cheung, Yick Ching Lam, Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Koon Mian Foo, Wei-Jen Kiley Loh, Si-Lin Koo, Amit Jain, Guek Eng Lee, Rebecca Dent, Yoon Sim Yap, Raymond Ng, Alexandre Chan
OBJECTIVES: Currently, there are no studies that have established the self-perceived cognitive trajectories experienced by breast cancer patients (BCPs) post-chemotherapy. Therefore, we characterized the long-term trajectory of self-perceived cognitive function among Asian early-stage BCPs using the minimal clinically important difference (MCID) of a subjective measure of cognitive function. METHODS: Early-stage BCPs who received chemotherapy were recruited and assessed at four time points: Before chemotherapy initiation (T1), 6 weeks post-chemotherapy initiation (T2), 12 weeks post-chemotherapy initiation (T3), and 15-months post-chemotherapy initiation (T4)...
January 9, 2018: Psycho-oncology
Terence Ng, Ying Yun Lee, Jung-Woo Chae, Angie Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Raymond C H Ng, Pat Pak Yan Chu, Chiea Chuen Khor, Han Kiat Ho, Alexandre Chan
BACKGROUND: Preliminary evidence suggests that changes in plasma brain-derived neurotrophic factor (BDNF) levels may contribute to the occurrence of chemotherapy-associated cognitive impairment (CACI), and a previous study suggested that carriers of the BDNF Met homozygous genotype are protected from CACI. METHODS: This multicenter, prospective cohort study involved chemotherapy-receiving early-stage breast cancer (ESBC) patients. Self-perceived cognitive function was longitudinally assessed using the validated FACT-Cog (ver...
December 19, 2017: BMC Cancer
Timothy J Flanigan, Julie E Anderson, Ikram Elayan, Antiño R Allen, Sherry A Ferguson
Post-chemotherapy cognitive impairment, or PCCI, is a common complaint, particularly among breast cancer patients. However, the exact nature of PCCI appears complex. To model the human condition, ovariectomized C57BL/6J mice were treated iv weekly for 4 weeks with saline, 2 mg/kg doxorubicin (DOX), 50 mg/kg cyclophosphamide (CYP), or DOX+CYP. For the subsequent 10 weeks, mice were assessed on several behavioral tests, including those measuring spatial learning and memory. After sacrifice, hippocampal spine density and morphology in the dentate gyrus, CA1, and CA3 regions were measured...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
Christopher Atkins, Richard Fordham, Allan B Clark, Andrea Stockl, Andrew P Jones, Andrew M Wilson
INTRODUCTION: Fatigue is a frequent and troublesome manifestation of chronic sarcoidosis. This symptom can be debilitating and difficult to treat, with poor response to the treatment. Symptomatic management with neurostimulants, such as methylphenidate, is a possible treatment option. The use of such treatment strategies is not without precedent and has been trialled in cancer-related fatigue. Their use in sarcoidosis requires further evaluation before it can be recommended for clinical practice...
December 4, 2017: BMJ Open
Shelli R Kesler, Arvind Rao, Douglas W Blayney, Ingrid A Oakley-Girvan, Meghan Karuturi, Oxana Palesh
We aimed to determine if resting state functional magnetic resonance imaging (fMRI) acquired at pre-treatment baseline could accurately predict breast cancer-related cognitive impairment at long-term follow-up. We evaluated 31 patients with breast cancer (age 34-65) prior to any treatment, post-chemotherapy and 1 year later. Cognitive testing scores were normalized based on data obtained from 43 healthy female controls and then used to categorize patients as impaired or not based on longitudinal changes. We measured clustering coefficient, a measure of local connectivity, by applying graph theory to baseline resting state fMRI and entered these metrics along with relevant patient-related and medical variables into random forest classification...
2017: Frontiers in Human Neuroscience
Yingchun Zeng, Andy S K Cheng, Ting Song, Xiujie Sheng, Yang Zhang, Xiangyu Liu, Chetwyn C H Chan
BACKGROUND: Subjective cognitive impairment can be a significant and prevalent problem for gynaecological cancer survivors. The aims of this study were to assess subjective cognitive functioning in gynaecological cancer survivors after primary cancer treatment, and to investigate the impact of cancer treatment on brain structural networks and its association with subjective cognitive impairment. METHODS: This was a cross-sectional survey using a self-reported questionnaire by the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) to assess subjective cognitive functioning, and applying DTI (diffusion tensor imaging) and graph theoretical analyses to investigate brain structural networks after primary cancer treatment...
November 28, 2017: BMC Cancer
Chidinma C Ebede, Yongchang Jang, Carmen P Escalante
Cancer-related fatigue (CRF) significantly interferes with usual functioning because of the distressing sense of physical, emotional, and cognitive exhaustion. Assessment of CRF is important and should be performed during the initial cancer diagnosis, throughout cancer treatment, and after treatment using a fatigue scoring scale (mild-severe). The general approach to CRF management applies to cancer survivors at all fatigue levels and includes education, counseling, and other strategies. Nonpharmacologic interventions include psychosocial interventions, exercise, yoga, physically based therapy, dietary management, and sleep therapy...
November 2017: Medical Clinics of North America
Yingwei Qiu, Zheng Guo, Lujun Han, Yadi Yang, Jing Li, Shiliang Liu, Xiaofei Lv
In this study, we seek to longitudinally investigate the network-level functional connectivity (FC) alternations and its association with irradiation dose and cognition changes in the early stage post radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients. We performed independent component analysis (ICA) of resting state blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) from 39 newly diagnosed NPC patients before receiving treatment (baseline), and 3 months post-RT. the default mode network (DMN), salience network (SN), and executive control network (ECN) were extracted with well-validated software (GIFT)...
November 21, 2017: Brain Imaging and Behavior
D D Correa, M Kryza-Lacombe, X Zhou, R E Baser, B J Beattie, Z Beiene, J Humm, L M DeAngelis, I Orlow, W Weber, J Osborne
Brain tumor patients treated with radiotherapy (RT) often develop cognitive dysfunction, and recent studies suggest that the APOE ε-4 allele may influence cognitive outcome. The ε-4 allele is known to promote beta (β) amyloid deposition in the cortex, and preliminary evidence suggests that RT may be associated with this process. However, it is unknown whether β-amyloid accumulation contributes to treatment neurotoxicity. In this pilot study, we assessed neuropsychological functions and β-amyloid retention using18 F-florbetaben (FBB) PET in a subset of brain tumor patients who participated in our study of APOE polymorphisms and cognitive functions...
February 2018: Journal of Neuro-oncology
A Matsos, M Loomes, I Zhou, E Macmillan, I Sabel, E Rotziokos, W Beckwith, I N Johnston
Whilst chemotherapeutic agents show promising results in the amelioration of cancerous tumors, patients often experience cognitive disturbances associated with chemotherapy long after treatment has ceased. Research has suggested that the structural integrity of white matter fibres in the brain are susceptible to the harmful effects of chemotherapy. Post-chemotherapy, white matter tracts often display altered morphology with a reduction in glial cells such as oligodendrocytes. Demyelination, gliosis and leukoencephalopathy during or post chemotherapy is associated with changes in processing speed and IQ...
December 2017: Cancer Treatment Reviews
Lori J Bernstein, Graham A McCreath, Zahra Komeylian, Jill B Rich
Women with breast cancer can experience persisting cognitive deficits post treatment. We conducted a multilevel meta-analysis of cognitive function in survivors treated with chemotherapy (Ch+) to estimate the magnitude of cognitive impairment relative to healthy (HC) and chemo-negative (Ch-) controls. Seventy-two studies published up to October 2016 involving 2939 Ch+ yielded 1594 effect sizes. Ch+ demonstrated overall cognitive impairment in comparison with HC but not with Ch-. Relative to HC, Ch+ showed impairment in attention/concentration, processing speed, language, immediate recall, delayed recall, and executive function...
October 29, 2017: Neuroscience and Biobehavioral Reviews
Ryosuke Kitahata, Shinichiro Nakajima, Hiroyuki Uchida, Tetsu Hayashida, Maiko Takahashi, Shintaro Nio, Jinichi Hirano, Maki Nagaoka, Takefumi Suzuki, Hiromitsu Jinno, Yuko Kitagawa, Masaru Mimura
PURPOSE: The purpose of the study was to evaluate subjective (self-rated), family-rated, and objective (researcher-rated) cognitive functions in patients with breast cancer after chemotherapy. METHOD: We conducted a prospective study to trace self-rated cognitive functions in 30 patients with breast cancer at the completion of chemotherapy (T0) and 6 months later (T1). Subjective cognitive functions were assessed with Cognitive Failures Questionnaire (CFQ), Dysexecutive Questionnaire (DEX-S), and Everyday Memory Checklist (EMC-S) for attention, executive function, and episodic memory, respectively...
2017: Neuropsychiatric Disease and Treatment
Ellen Van Der Plas, Lauren Erdman, Brian J Nieman, Rosanna Weksberg, Darci T Butcher, Deborah L O'connor, Susanne Aufreiter, Johann Hitzler, Sharon L Guger, Russell J Schachar, Shinya Ito, Brenda J Spiegler
Knowledge about cognitive late effects in survivors of childhood acute lymphoblastic leukemia (ALL) is largely based on standardized neuropsychological measures and parent reports. To examine whether cognitive neuroscience paradigms provided additional insights into neurocognitive and behavioral late effects in ALL survivors, we assessed cognition and behavior using a selection of cognitive neuroscience tasks and standardized measures probing domains previously demonstrated to be affected by chemotherapy. 130 ALL survivors and 158 control subjects, between 8 and 18 years old at time of testing, completed the n-back (working memory) and stop-signal (response inhibition) tasks...
October 10, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
Meric A Altinoz, İlhan Elmaci
Glioblastoma multiforme (GBM) is a devastating brain cancer with no curative treatment. Targeting Nitric Oxide (NO) and glutamatergic pathways may help as adjunctive treatments in GBM. NO at low doses promotes tumorigenesis, while at higher levels (above 300 nM) triggers apoptosis. Gliomas actively secrete high amounts of glutamate which activates EGR signaling and mediates degradation of peritumoral tissues via excitotoxic injury. Memantine inhibits NMDA-subtype of glutamate receptors (NMDARs) and induces autophagic death of glioma cells in vitro and blocks glioma growth in vivo...
October 10, 2017: Nitric Oxide: Biology and Chemistry
Agnieszka Kolak, Marzena Kamińska, Elwira Wysokińska, Dariusz Surdyka, Dariusz Kieszko, Magdalena Pakieła, Franciszek Burdan
Modern therapeutic management of patients with cancer is associated with many adverse side effects, including fatigue defined as weariness, burnout, lassitude, malaise, apathy, impatience, and/or inability to perform daily activities. It occurs frequently before the diagnosis of cancer and may persist for a long time after the end of cancer therapy. It is a common problem that occurs regardless of the type of cancer and applied therapeutic procedure. The appearance of this symptom significantly affects the quality of life of patients and often reduces the effectiveness of implemented treatment...
2017: Contemporary Oncology Współczesna Onkologia
Matthew J Ehrhardt, Daniel A Mulrooney, Chenghong Li, Malek J Baassiri, Kari Bjornard, John T Sandlund, Tara M Brinkman, I-Chan Huang, Deo Kumar Srivastava, Kirsten K Ness, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Children with non-Hodgkin lymphoma (NHL) undergo treatment with central nervous system-directed therapy, the potentially neurotoxic effects of which have not been reported in NHL survivors. METHODS: NHL survivors (n = 187) participating in the St. Jude Lifetime Cohort who were 10 or more years from their diagnosis and were 18 years old or older underwent neurocognitive, emotional distress (Brief Symptom Inventory 18), and health-related quality of life (HRQOL) assessments (36-Item Short Form Health Survey)...
September 15, 2017: Cancer
Rocío Rojí, Carlos Centeno
PURPOSE OF REVIEW: To review recent evidence on the efficacy and safety of methylphenidate as a symptomatic treatment of patients with cancer-related fatigue (CRF). RECENT FINDINGS: Five clinical trials published since 2011 were identified. Two of these concluded that methylphenidate is more efficacious than placebo in providing relief from CRF, but the remaining three showed no difference in favour of methylphenidate. The studies were heterogeneous as per the dosage, scales used for evaluating fatigue and the target group studied...
December 2017: Current Opinion in Supportive and Palliative Care
Danielle Panoz-Brown, Lawrence M Carey, Alexandra E Smith, Meredith Gentry, Christina M Sluka, Hannah E Corbin, Jie-En Wu, Andrea G Hohmann, Jonathon D Crystal
Chemotherapy is widely used to treat patients with systemic cancer. The efficacy of cancer therapies is frequently undermined by adverse side effects that have a negative impact on the quality of life of cancer survivors. Cancer patients who receive chemotherapy often experience chemotherapy-induced cognitive impairment across a variety of domains including memory, learning, and attention. In the current study, the impact of paclitaxel, a taxane derived chemotherapeutic agent, on episodic memory, prior learning, new learning, and reversal learning were evaluated in rats...
October 2017: Neurobiology of Learning and Memory
2017-08-30 17:33:23
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