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Global Health

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By Ana Monteiro Md/phd student
Liwang Cui, Sungano Mharakurwa, Daouda Ndiaye, Pradipsinh K Rathod, Philip J Rosenthal
Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases in the global malaria burden are likely due, in part, to the deployment of artemisinin-based combination therapies. Therefore, the emergence and potential spread of artemisinin-resistant parasites in southeast Asia and changes in sensitivities to artemisinin partner drugs have raised concerns. In recognition of this urgent threat, the International Centers of Excellence for Malaria Research (ICEMRs) are closely monitoring antimalarial drug efficacy and studying the mechanisms underlying drug resistance...
September 2015: American Journal of Tropical Medicine and Hygiene
Kevin S Griffith, Linda S Lewis, Sonja Mali, Monica E Parise
CONTEXT: Many US clinicians and laboratory personnel are unfamiliar with the diagnosis and treatment of malaria. OBJECTIVES: To examine the evidence base for management of uncomplicated and severe malaria and to provide clinicians with practical recommendations for the diagnosis and treatment of malaria in the United States. EVIDENCE ACQUISITION: Systematic MEDLINE search from 1966 to 2006 using the search term malaria (with the subheadings congenital, diagnosis, drug therapy, epidemiology, and therapy)...
May 23, 2007: JAMA: the Journal of the American Medical Association
Sonja A Rasmussen, Denise J Jamieson, Margaret A Honein, Lyle R Petersen
Summary. The Zika virus has spread rapidly in the Americas since its first identification in Brazil in early 2015. Prenatal Zika virus infection has been linked to adverse pregnancy and birth outcomes, most notably microcephaly and other serious brain anomalies. To determine whether Zika virus..
May 19, 2016: New England Journal of Medicine
Arjen Dondorp, Fran├žois Nosten, Kasia Stepniewska, Nick Day, Nick White
BACKGROUND: In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain. METHODS: We did an open-label randomised controlled trial in patients admitted to hospital with severe falciparum malaria in Bangladesh, India, Indonesia, and Myanmar. We assigned individuals intravenous artesunate 2.4 mg/kg bodyweight given as a bolus (n=730) at 0, 12, and 24 h, and then daily, or intravenous quinine (20 mg salt per kg loading dose infused over 4 h then 10 mg/kg infused over 2-8 h three times a day; n=731)...
August 27, 2005: Lancet
David G Lalloo, Delane Shingadia, David J Bell, Nicholas J Beeching, Christopher J M Whitty, Peter L Chiodini
1.Malaria is the tropical disease most commonly imported into the UK, with 1300-1800 cases reported each year, and 2-11 deaths. 2. Approximately three quarters of reported malaria cases in the UK are caused by Plasmodium falciparum, which is capable of invading a high proportion of red blood cells and rapidly leading to severe or life-threatening multi-organ disease. 3. Most non-falciparum malaria cases are caused by Plasmodium vivax; a few cases are caused by the other species of plasmodium: Plasmodium ovale, Plasmodium malariae or Plasmodium knowlesi...
June 2016: Journal of Infection
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