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HAP

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4 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28039187/initial-combination-therapy-with-ambrisentan-and-tadalafil-in-connective-tissue-disease-associated-pulmonary-arterial-hypertension-ctd-pah-subgroup-analysis-from-the-ambition-trial
#1
John Gerry Coghlan, Nazzareno Galiè, Joan Albert Barberà, Adaani E Frost, Hossein-Ardeschir Ghofrani, Marius M Hoeper, Masataka Kuwana, Vallerie V McLaughlin, Andrew J Peacock, Gérald Simonneau, Jean-Luc Vachiéry, Christiana Blair, Hunter Gillies, Karen L Miller, Julia H N Harris, Jonathan Langley, Lewis J Rubin
BACKGROUND: Patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH), in particular systemic sclerosis (SSc), had an attenuated response compared with idiopathic PAH in most trials. Thus, there is uncertainty regarding the benefit of PAH-targeted therapy in some forms of CTD-PAH. OBJECTIVE: To explore the safety and efficacy of initial combination therapy with ambrisentan and tadalafil versus ambrisentan or tadalafil monotherapy in patients with CTD-PAH and SSc-PAH enrolled in the AMBITION trial...
December 30, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27679806/contemporary-diagnosis-and-management-of-pulmonary-hypertension
#2
J E Cannon, J Pepke-Zaba
No abstract text is available yet for this article.
October 15, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27457511/riociguat-for-the-treatment-of-pulmonary-arterial-hypertension-associated-with-connective-tissue-disease-results-from-patent-1-and-patent-2
#3
Marc Humbert, J Gerry Coghlan, Hossein-Ardeschir Ghofrani, Friedrich Grimminger, Jian-Guo He, Gabriela Riemekasten, Carmine Dario Vizza, Annette Boeckenhoff, Christian Meier, Janethe de Oliveira Pena, Christopher P Denton
BACKGROUND: The 12-week, phase III Pulmonary Arterial hyperTENsion sGC-stimulator Trial (PATENT)-1 study investigated riociguat in patients with pulmonary arterial hypertension (PAH). Here, we present a prospectively planned analysis of the safety and efficacy of riociguat in the subgroup of patients with PAH associated with connective tissue disease (PAH-CTD). METHODS: Patients with PAH-CTD were further classified post hoc as having PAH associated with systemic sclerosis or PAH-other defined CTD...
February 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27141034/pulmonary-hypertension-diagnostic-approach-and-optimal-management
#4
REVIEW
Nathan Hambly, Fahad Alawfi, Sanjay Mehta
No abstract text is available yet for this article.
August 9, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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