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Edison Manrique-Garcia, Antonio Ponce de Leon, Christina Dalman, Sven Andréasson, Peter Allebeck
OBJECTIVE: The authors assessed 1) the overall risk of death among cannabis users compared with nonusers and the extent to which psychosis affects excess mortality; 2) mortality among persons with psychotic disorders and the extent to which cannabis use affects excess mortality; and 3) the interaction effect of cannabis use and diagnosis of psychotic disorders on mortality. METHOD: This was a longitudinal study of 50,373 Swedish male military conscripts (ages 18-19) who were followed in the National Cause of Death Register up to around age 60...
August 1, 2016: American Journal of Psychiatry
Marco Colizzi, Conrad Iyegbe, John Powell, Gianluca Ursini, Annamaria Porcelli, Aurora Bonvino, Paolo Taurisano, Raffaella Romano, Rita Masellis, Giuseppe Blasi, Craig Morgan, Katherine Aitchison, Valeria Mondelli, Sonija Luzi, Anna Kolliakou, Anthony David, Robin M Murray, Alessandro Bertolino, Marta Di Forti
Both cannabis use and the dopamine receptor (DRD2) gene have been associated with schizophrenia, psychosis-like experiences, and cognition. However, there are no published data investigating whether genetically determined variation in DRD2 dopaminergic signaling might play a role in individual susceptibility to cannabis-associated psychosis. We genotyped (1) a case-control study of 272 patients with their first episode of psychosis and 234 controls, and also from (2) a sample of 252 healthy subjects, for functional variation in DRD2, rs1076560...
September 2015: Schizophrenia Bulletin
Martin R Wilkins
No abstract text is available yet for this article.
January 2006: Clinical Medicine: Journal of the Royal College of Physicians of London
S Aldington, M Harwood, B Cox, M Weatherall, L Beckert, A Hansell, A Pritchard, G Robinson, R Beasley
The aim of the present study was to determine the risk of lung cancer associated with cannabis smoking. A case-control study of lung cancer in adults <or=55 yrs of age was conducted in eight district health boards in New Zealand. Cases were identified from the New Zealand Cancer Registry and hospital databases. Controls were randomly selected from the electoral roll, with frequency matching to cases in 5-yr age groups and district health boards. Interviewer-administered questionnaires were used to assess possible risk factors, including cannabis use...
February 2008: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Li Rita Zhang, Hal Morgenstern, Sander Greenland, Shen-Chih Chang, Philip Lazarus, M Dawn Teare, Penella J Woll, Irene Orlow, Brian Cox, Yonathan Brhane, Geoffrey Liu, Rayjean J Hung
To investigate the association between cannabis smoking and lung cancer risk, data on 2,159 lung cancer cases and 2,985 controls were pooled from 6 case-control studies in the US, Canada, UK, and New Zealand within the International Lung Cancer Consortium. Study-specific associations between cannabis smoking and lung cancer were estimated using unconditional logistic regression adjusting for sociodemographic factors, tobacco smoking status and pack-years; odds-ratio estimates were pooled using random effects models...
February 15, 2015: International Journal of Cancer. Journal International du Cancer
Chittaranjan Andrade
Cannabis is popularly believed to be a relatively benign substance. Cannabis is also considered to have potential medical benefits, and medical marijuana has been legislated in many parts of the world. However, a recent meta-analysis found that cannabinoids were associated with only modest benefits for chemotherapy-related nausea and vomiting, small and inconsistent benefits for pain and spasticity, and inconclusive benefits for other indications such as improvement of appetite and weight, reduction in tic severity, and improvement of mood or sleep...
May 2016: Journal of Clinical Psychiatry
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