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Addiction Science to Practice

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3 papers 0 to 25 followers The accurate definition and description of addiction, as a biopsychsocial BRAIN disease,is the base of this collection of research & reviews with an immediate implication for clinical practice or all disciplines.
Nai-gang Liu, Chang-qing Guo, Hong-mei Sun, Xiao-hong Li, Hai-xia Wu, Hong Xu
OBJECTIVE: To explore the analgesic mechanism of small knife needle for treating transverse process syndrome of the third vertebra (TPSTV) by observing peripheral and central changesof β-endorphin (β-EP) and enkephalin (ENK) contents. METHODS: Totally 30 Japanese white big-ear rabbits of clean grade were divided into 5 groups according to random digit table, i.e., the normal control group, the model group, the small knife needle group, the electroacupunture (EA) group, and the small knife needle plus EA group, 6 in each group...
April 2016: Chinese Journal of Integrated Traditional and Western Medicine
Vincent Pascoli, Jean Terrier, Agnès Hiver, Christian Lüscher
The factors causing the transition from recreational drug consumption to addiction remain largely unknown. It has not been tested whether dopamine (DA) is sufficient to trigger this process. Here we use optogenetic self-stimulation of DA neurons of the ventral tegmental area (VTA) to selectively mimic the defining commonality of addictive drugs. All mice readily acquired self-stimulation. After weeks of abstinence, cue-induced relapse was observed in parallel with a potentiation of excitatory afferents onto D1 receptor-expressing neurons of the nucleus accumbens (NAc)...
December 2, 2015: Neuron
Markus Heilig, David H Epstein, Michael A Nader, Yavin Shaham
Research on the neural substrates of drug reward, withdrawal and relapse has yet to be translated into significant advances in the treatment of addiction. One potential reason is that this research has not captured a common feature of human addiction: progressive social exclusion and marginalization. We propose that research aimed at understanding the neural mechanisms that link these processes to drug seeking and drug taking would help to make addiction neuroscience research more clinically relevant.
September 2016: Nature Reviews. Neuroscience
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