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Genetics and genomics of addiction

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https://www.readbyqxmd.com/read/27269905/african-specific-variability-in-the-acetylcholine-muscarinic-receptor-m4-association-with-cocaine-and-heroin-addiction
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Orna Levran, Matthew Randesi, Einat Peles, Joel Correa da Rosa, Jurg Ott, John Rotrosen, Miriam Adelson, Mary Jeanne Kreek
AIM: This study was designed to determine whether polymorphisms in acetylcholine receptors contribute to opioid dependence and/or cocaine dependence. PATIENTS & METHODS: The sample (n = 1860) was divided by drug and ancestry, and 55 polymorphisms (nine genes) were analyzed. RESULTS: Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing (Pcorrected = 0...
June 2016: Pharmacogenomics
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