collection
MENU ▼
Read by QxMD icon Read
search

Cannabinoid + immune suppression

shared collection
5 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27038180/marijuana-derived-%C3%AE-9-tetrahydrocannabinol-suppresses-th1-th17-cell-mediated-delayed-type-hypersensitivity-through-microrna-regulation
#1
Jessica M Sido, Austin R Jackson, Prakash S Nagarkatti, Mitzi Nagarkatti
UNLABELLED: ∆(9)-Tetrahydrocannabinol (THC) is one of the major bioactive cannabinoids derived from the Cannabis sativa plant and is known for its anti-inflammatory properties. Delayed-type hypersensitivity (DTH) is driven by proinflammatory T helper cells including the classic inflammatory Th1 lineage as well as the more recently discovered Th17 lineage. In the current study, we investigated whether THC can alter the induction of Th1/Th17 cells involved in mBSA-induced DTH response...
September 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/22496569/tumor-necrosis-factor-activation-of-vagal-afferent-terminal-calcium-is-blocked-by-cannabinoids
#2
Richard C Rogers, Gerlinda E Hermann
The early proinflammatory cytokine tumor necrosis factor (TNF) is released in significant quantities by the activated immune system in response to infection, leukemia, autoimmune disorders, and radiation sickness. Nausea, emesis, and anorexia are common features of these disorders. TNF action on vagal afferent terminals in the brainstem is a likely cause of the malaise associated with these disorders. Our previous work has shown that TNF action to excite vagal afferents occurs as a result of sensitization of ryanodine channels in afferent nerve terminals...
April 11, 2012: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26034207/%C3%AE-%C3%A2-tetrahydrocannabinol-attenuates-allogeneic-host-versus-graft-response-and-delays-skin-graft-rejection-through-activation-of-cannabinoid-receptor-1-and-induction-of-myeloid-derived-suppressor-cells
#3
Jessica M Sido, Prakash S Nagarkatti, Mitzi Nagarkatti
Immune cells have been shown to express cannabinoid receptors and to produce endogenous ligands. Moreover, activation of cannabinoid receptors on immune cells has been shown to trigger potent immunosuppression. Despite such studies, the role of cannabinoids in transplantation, specifically to prevent allograft rejection, has not, to our knowledge, been investigated previously. In the current study, we tested the effect of THC on the suppression of HvGD as well as rejection of skin allografts. To this end, we studied HvGD by injecting H-2(k) splenocytes into H-2(b) mice and analyzing the immune response in the draining ingLNs...
September 2015: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/23261520/the-role-of-cb1-in-immune-modulation-by-cannabinoids
#4
REVIEW
Barbara L F Kaplan
There is clear evidence that CB(2), historically referred to as the peripheral cannabinoid receptor, mediates many of the immune modulatory effects of cannabinoids. However, cannabinoid receptors cannot be classified simply as central or peripheral since CB(2) has been shown to play a role in the central nervous system (CNS) and CB(1) mediates many immune system effects. Although Cnr1 mRNA and CB(1) protein expression is lower than Cnr2 mRNA or CB(2) protein expression in cells of the immune system, several studies have shown direct modulation of immune function via CB(1) by endogenous and exogenous cannabinoids in T cells, innate cells, and to a lesser extent, B cells...
March 2013: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/22972984/signaling-through-cannabinoid-receptor-2-suppresses-murine-dendritic-cell-migration-by-inhibiting-matrix-metalloproteinase-9-expression
#5
Sabina Adhikary, Virginia P Kocieda, Jui-Hung Yen, Ronald F Tuma, Doina Ganea
Administration of cannabinoid receptor 2 (CB2R) agonists in inflammatory and autoimmune disease and CNS injury models results in significant attenuation of clinical disease, and reduction of inflammatory mediators. Previous studies reported that CB2R signaling also reduces leukocyte migration. Migration of dendritic cells (DCs) to various sites is required for their activation and for the initiation of adaptive immune responses. Here, we report for the first time that CB2R signaling affects DC migration in vitro and in vivo, primarily through the inhibition of matrix metalloproteinase 9 (MMP-9) expression...
November 1, 2012: Blood
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"