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Paracetamol VLBW TDA

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1 papers 0 to 25 followers VLBW
Pia Härkin, Antti Härmä, Outi Aikio, Marita Valkama, Markku Leskinen, Timo Saarela, Mikko Hallman
OBJECTIVE: To study the biologic effect of paracetamol, an inhibitor of prostaglandin synthase, on early closure of ductus arteriosus, and to evaluate possible adverse effects associated with the drug. STUDY DESIGN: In a controlled, double-blind, phase I-II trial, very low gestational age (<32 weeks) infants requiring intensive care were randomly assigned to intravenous paracetamol or placebo (0.45% NaCl). A loading dose of 20 mg/kg was given within 24 hours of birth, followed by 7...
October 2016: Journal of Pediatrics
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