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Sign Up#21
REVIEW
Julio Saez-Rodriguez, James C Costello, Stephen H Friend, Michael R Kellen, Lara Mangravite, Pablo Meyer, Thea Norman, Gustavo Stolovitzky
The generation of large-scale biomedical data is creating unprecedented opportunities for basic and translational science. Typically, the data producers perform initial analyses, but it is very likely that the most informative methods may reside with other groups. Crowdsourcing the analysis of complex and massive data has emerged as a framework to find robust methodologies. When the crowdsourcing is done in the form of collaborative scientific competitions, known as Challenges, the validation of the methods is inherently addressed...
July 15, 2016: Nature Reviews. Genetics
#22
REVIEW
Gerrit Frommeyer, Lars Eckardt
Drug-induced ventricular tachyarrhythmias can be caused by cardiovascular drugs, noncardiovascular drugs, and even nonprescription agents. They can result in arrhythmic emergencies and sudden cardiac death. If a new arrhythmia or aggravation of an existing arrhythmia develops during therapy with a drug at a concentration usually considered not to be toxic, the situation can be defined as proarrhythmia. Various cardiovascular and noncardiovascular drugs can increase the occurrence of polymorphic ventricular tachycardia of the 'torsade de pointes' type...
January 2016: Nature Reviews. Cardiology
#23
EDITORIAL
Alexandre C Pereira
No abstract text is available yet for this article.
October 15, 2016: Heart
#24
JOURNAL ARTICLE
Marcio Sommer Bittencourt, Edward Hulten, Tamar S Polonsky, Udo Hoffman, Khurram Nasir, Suhny Abbara, Marcelo Di Carli, Ron Blankstein
BACKGROUND: The most appropriate score for evaluating the pretest probability of obstructive coronary artery disease (CAD) is unknown. We sought to compare the Diamond-Forrester (DF) score with the 2 CAD consortium scores recently recommended by the European Society of Cardiology. METHODS: We included 2274 consecutive patients (age, 56±13 years; 57% male) without prior CAD referred for coronary computed tomographic angiography. Computed tomographic angiography findings were used to determine the presence or absence of obstructive CAD (≥50% stenosis)...
July 19, 2016: Circulation
#25
REVIEW
Sarah Bowdin, Adel Gilbert, Emma Bedoukian, Christopher Carew, Margaret P Adam, John Belmont, Barbara Bernhardt, Leslie Biesecker, Hans T Bjornsson, Miriam Blitzer, Lisa C A D'Alessandro, Matthew A Deardorff, Laurie Demmer, Alison Elliott, Gerald L Feldman, Ian A Glass, Gail Herman, Lucia Hindorff, Fuki Hisama, Louanne Hudgins, A Micheil Innes, Laird Jackson, Gail Jarvik, Raymond Kim, Bruce Korf, David H Ledbetter, Mindy Li, Eriskay Liston, Christian Marshall, Livija Medne, M Stephen Meyn, Nasim Monfared, Cynthia Morton, John J Mulvihill, Sharon E Plon, Heidi Rehm, Amy Roberts, Cheryl Shuman, Nancy B Spinner, D James Stavropoulos, Kathleen Valverde, Darrel J Waggoner, Alisha Wilkens, Ronald D Cohn, Ian D Krantz
The introduction of diagnostic clinical genome and exome sequencing (CGES) is changing the scope of practice for clinical geneticists. Many large institutions are making a significant investment in infrastructure and technology, allowing clinicians to access CGES, especially as health-care coverage begins to extend to clinically indicated genomic sequencing-based tests. Translating and realizing the comprehensive clinical benefits of genomic medicine remain a key challenge for the current and future care of patients...
November 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#26
JOURNAL ARTICLE
Elizabeth Bass
No abstract text is available yet for this article.
June 7, 2016: Circulation
#27
REVIEW
Mehri Karimi, Alexander M Clark
BACKGROUND: Values are central to ethical and effective nursing and health care. However, in relation to heart failure, an extremely common and burdensome syndrome, the role that patients' values have in influencing self-care is poorly understood. METHODS: A mixed methods systematic review was conducted using a critical meta-narrative synthesis approach to synthesizing qualitative and qualitized data. Nine databases were searched (14 March 2014). To be included in the review, studies had to contain data on heart failure patients' values and self-care behaviors, include adults aged ≥18 years with symptomatic heart failure, and be published ≥2000 as full articles or theses...
July 2016: International Journal of Nursing Studies
#28
JOURNAL ARTICLE
Daniel Sarewitz
No abstract text is available yet for this article.
May 12, 2016: Nature
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