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Atrial Fibrillation

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29 papers 0 to 25 followers
Daniel F Gudbjartsson, Hilma Holm, Patrick Sulem, Gisli Masson, Asmundur Oddsson, Olafur Th Magnusson, Jona Saemundsdottir, Hafdis Th Helgadottir, Hannes Helgason, Hrefna Johannsdottir, Solveig Gretarsdottir, Sigurjon A Gudjonsson, Inger Njølstad, Maja-Lisa Løchen, Larry Baum, Ronald C W Ma, Gunnlaugur Sigfusson, Augustine Kong, Guðmundur Thorgeirsson, Jon Th Sverrisson, Unnur Thorsteinsdottir, Kari Stefansson, David O Arnar
AIMS: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in man, causing substantial morbidity and mortality with a major worldwide public health impact. It is increasingly recognized as a highly heritable condition. This study aimed to determine genetic risk factors for early-onset AF. METHODS AND RESULTS: We sequenced the whole genomes of 8453 Icelanders and imputed genotypes of the 25.5 million sequence variants we discovered into 1799 Icelanders with early-onset AF (diagnosed before 60 years of age) and 337 453 controls...
October 14, 2016: European Heart Journal
Nico Hartmann, Steffen Pabel, Jonas Herting, Felix Schatter, André Renner, Jan Gummert, Hanna Schotola, Bernhard C Danner, Lars S Maier, Norbert Frey, Gerd Hasenfuss, Thomas H Fischer, Samuel Sossalla
BACKGROUND: Cardiac type 2 ryanodine receptors (RyR2s) play a pivotal role in cellular electrophysiology and contractility. Increased RyR2-mediated diastolic sarcoplasmic reticulum (SR) Ca(2+) release is linked to heart failure (HF) and arrhythmias. Dantrolene, a drug used for the treatment of malignant hyperthermia, is known to stabilize RyRs in skeletal muscle. OBJECTIVE: The purpose of this study was to investigate the effects of dantrolene on arrhythmogenic triggers and contractile function in human atrial fibrillation (AF) and HF cardiomyocytes (CM)...
September 17, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Hein Heidbuchel
No abstract text is available yet for this article.
September 20, 2016: Heart: Official Journal of the British Cardiac Society
Laurent Macle, John Cairns, Kori Leblanc, Teresa Tsang, Allan Skanes, Jafna L Cox, Jeff S Healey, Alan Bell, Louise Pilote, Jason G Andrade, L Brent Mitchell, Clare Atzema, David Gladstone, Mike Sharma, Subodh Verma, Stuart Connolly, Paul Dorian, Ratika Parkash, Mario Talajic, Stanley Nattel, Atul Verma
The Canadian Cardiovascular Society (CCS) Atrial Fibrillation (AF) Guidelines Committee provides periodic reviews of new data to produce focused updates that address clinically important advances in AF management. This 2016 Focused Update deals with: (1) the management of antithrombotic therapy for AF patients in the context of the various clinical presentations of coronary artery disease; (2) real-life data with non-vitamin K antagonist oral anticoagulants; (3) the use of antidotes for the reversal of non-vitamin K antagonist oral anticoagulants; (4) digoxin as a rate control agent; (5) perioperative anticoagulation management; and (6) AF surgical therapy including the prevention and treatment of AF after cardiac surgery...
October 2016: Canadian Journal of Cardiology
Fabian Sanchis-Gomar, Alejandro Lucia
No abstract text is available yet for this article.
September 6, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Paulus Kirchhof, Stefano Benussi, Dipak Kotecha, Anders Ahlsson, Dan Atar, Barbara Casadei, Manuel Castella, Hans-Christoph Diener, Hein Heidbuchel, Jeroen Hendriks, Gerhard Hindricks, Antonis S Manolis, Jonas Oldgren, Bogdan Alexandru Popescu, Ulrich Schotten, Bart Van Putte, Panagiotis Vardas
No abstract text is available yet for this article.
August 27, 2016: European Heart Journal
Alejandro Liberos, Alfonso Bueno-Orovio, Miguel Rodrigo, Ursula Ravens, Ismael Hernandez-Romero, Francisco Fernandez-Aviles, Maria S Guillem, Blanca Rodriguez, Andreu M Climent
BACKGROUND: Atrial remodeling as a result of long-standing persistent atrial fibrillation (AF) induces substrate modifications that lead to different perpetuation mechanisms than in paroxysmal AF and a reduction in the efficacy of antiarrhythmic treatments. OBJECTIVE: The purpose of this study was to identify the ionic current modifications that could destabilize reentries during chronic AF and serve to personalize antiarrhythmic strategies. METHODS: A population of 173 mathematical models of remodeled human atrial tissue with realistic intersubject variability was developed based on action potential recordings of 149 patients diagnosed with AF...
August 26, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Hiroshige Yamabe, Hisanori Kanazawa, Miwa Ito, Shozo Kaneko, Hisao Ogawa
BACKGROUND: It remains unclear whether atrial fibrillation (AF) is maintained by the rotor. OBJECTIVE: We evaluated the role of the rotor and examined its mechanism. METHODS: Among 75 patients with AF (60 paroxysmal, 15 persistent AF) who underwent three-dimensional non-contact left atrial mapping during AF, we examined the prevalence and location of rotor activation and elucidated its mechanism. Catheter ablation was performed in a stepwise fashion (linear roof lesion and complex fractionated atrial electrogram ablation following pulmonary vein (PV) isolation) until AF termination...
July 30, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Mark S Link, Michel Haïssaguerre, Andrea Natale
Atrial fibrillation (AF) is the most common arrhythmia encountered by cardiologists and is a major cause of morbidity and mortality. Risk factors for AF include age, male sex, genetic predisposition, hypertension, diabetes mellitus, sleep apnea, obesity, excessive alcohol, smoking, hyperthyroidism, pulmonary disease, air pollution, heart failure, and possibly excessive exercise. The management of AF involves decisions about rate versus rhythm control. Asymptomatic patients are generally managed with rate control and anticoagulation...
July 26, 2016: Circulation
Ning Li, Thomas A Csepe, Brian J Hansen, Lidiya V Sul, Anuradha Kalyanasundaram, Stanislav O Zakharkin, Jichao Zhao, Avirup Guha, David R Van Wagoner, Ahmet Kilic, Peter J Mohler, Paul M L Janssen, Brandon J Biesiadecki, John D Hummel, Raul Weiss, Vadim V Fedorov
BACKGROUND: Adenosine provokes atrial fibrillation (AF) with a higher activation frequency in right atria (RA) versus left atria (LA) in patients, but the underlying molecular and functional substrates are unclear. We tested the hypothesis that adenosine-induced AF is driven by localized reentry in RA areas with highest expression of adenosine A1 receptor and its downstream GIRK (G protein-coupled inwardly rectifying potassium channels) channels (IK,Ado). METHODS: We applied biatrial optical mapping and immunoblot mapping of various atrial regions to reveal the mechanism of adenosine-induced AF in explanted failing and nonfailing human hearts (n=37)...
August 9, 2016: Circulation
Liang-Han Ling, Peter M Kistler, Jonathan M Kalman, Richard J Schilling, Ross J Hunter
Atrial fibrillation (AF) and heart failure (HF) are evolving epidemics, together responsible for substantial human suffering and health-care expenditure. Ageing, improved cardiovascular survival, and epidemiological transition form the basis for their increasing global prevalence. Although we now have a clear picture of how HF promotes AF, gaps remain in our knowledge of how AF exacerbates or even causes HF, and how the development of HF affects the outcome of patients with AF. New data regarding HF with preserved ejection fraction and its unique relationship with AF suggest a possible role for AF in its aetiology, possibly as a trigger for ventricular fibrosis...
March 2016: Nature Reviews. Cardiology
Andres Enriquez, Charles Antzelevitch, Verdah Bismah, Adrian Baranchuk
Atrial fibrillation (AF) is prevalent in cardiac channelopathies and may be the presenting feature in some patients. The pathogenesis is related to the primary ion channel dysfunction in atrial myocytes that affects atrial conduction or repolarization. The development of AF is associated with adverse outcomes, and its management is challenging in these patients. In this article we review the current information on the prevalence, risk factors, pathophysiology, and treatment of AF in specific cardiac channelopathies...
September 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Paulus Kirchhof, Hugh Calkins
Catheter ablation is increasingly offered to patients who suffer from symptoms due to atrial fibrillation (AF), based on a growing body of evidence illustrating its efficacy compared with antiarrhythmic drug therapy. Approximately one-third of AF ablation procedures are currently performed in patients with persistent or long-standing persistent AF. Here, we review the available information to guide catheter ablation in these more chronic forms of AF. We identify the following principles: Our clinical ability to discriminate paroxysmal and persistent AF is limited...
July 7, 2016: European Heart Journal
Karl-Heinz Kuck, Alexander Fürnkranz, K R Julian Chun, Andreas Metzner, Feifan Ouyang, Michael Schlüter, Arif Elvan, Hae W Lim, Fred J Kueffer, Thomas Arentz, Jean-Paul Albenque, Claudio Tondo, Michael Kühne, Christian Sticherling, Josep Brugada
AIMS: The primary safety and efficacy endpoints of the randomized FIRE AND ICE trial have recently demonstrated non-inferiority of cryoballoon vs. radiofrequency current (RFC) catheter ablation in patients with drug-refractory symptomatic paroxysmal atrial fibrillation (AF). The aim of the current study was to assess outcome parameters that are important for the daily clinical management of patients using key secondary analyses. Specifically, reinterventions, rehospitalizations, and quality-of-life were examined in this randomized trial of cryoballoon vs...
July 5, 2016: European Heart Journal
Paul A Heidenreich, Penelope Solis, N A Mark Estes, Gregg C Fonarow, Corrine Y Jurgens, Joseph E Marine, David D McManus, Robert L McNamara
No abstract text is available yet for this article.
August 2, 2016: Journal of the American College of Cardiology
Pieter W J Lozekoot, Monique M J de Jong, Orlando Parise, Francesco Matteucci, Fabiana Lucà, Narendra Kumar, Daniele Bani, Jens Czapla, Laurent Pison, Harry J G M Crijns, Jos G Maessen, Mark La Meir, Sandro Gelsomino
OBJECTIVE: We present the first testing study on the ABLA-BOX, a new in vitro module of hybrid atrial fibrillation ablation. METHODS: ABLA-BOX consists of two chambers that mimic the epicardial and endocardial sides of the heart. The septum between chambers provides catheter access on both sites of the cardiac tissue. A circuit, filled with freshly obtained porcine blood, including a pump, an oxygenator, and a heating device, circulate the blood inside the system...
May 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Dionyssios Leftheriotis, Panayota Flevari, Charalampos Kossyvakis, Dimitrios Katsaras, Chrysanthi Batistaki, Chrysa Arvaniti, Georgios Giannopoulos, Spyridon Deftereos, Georgia Kostopanagiotou, Ioannis Lekakis
BACKGROUND: In experimental models, stellate ganglion block (SGB) reduces the induction of atrial fibrillation (AF), while data in humans are limited. OBJECTIVE: The aim of this study was to assess the effect of unilateral SGB on atrial electrophysiological properties and AF induction in patients with paroxysmal AF. METHODS: Thirty-six patients with paroxysmal AF were randomized in a 2:1 order to temporary, transcutaneous, pharmaceutical SGB with lidocaine or placebo before pulmonary vein isolation...
June 21, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Marco Proietti, Giuseppe Boriani, Cécile Laroche, Igor Diemberger, Mircea I Popescu, Lars H Rasmussen, Gianfranco Sinagra, Gheorghe-Andrei Dan, Aldo P Maggioni, Luigi Tavazzi, Deirdre A Lane, Gregory Y H Lip
AIMS: Physical activity is protective against cardiovascular (CV) events, both in general population and in high-risk CV cohorts. However, the relationship between physical activity with major adverse outcomes in atrial fibrillation (AF) is not well-established. Our aim was to analyse this relationship in a 'real-world' AF population. Second, we investigated the influence of physical activity on arrhythmia progression. METHODS AND RESULTS: We studied all patients enrolled in the EURObservational Research Programme on AF (EORP-AF) Pilot Survey...
June 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Jonathan W Waks, Peter Zimetbaum
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and affects over 33 million people worldwide. AF is associated with stroke and systemic thromboembolism, unpleasant symptoms and reduced quality of life, heart failure, and increased mortality, and treatment of AF and its complications are associated with significant cost. Antiarrhythmic drugs (AADs) can suppress AF, allowing long-term maintenance of sinus rhythm, and have the potential to relieve symptoms and reverse or prevent adverse effects associated with AF...
June 2, 2016: Journal of Cardiovascular Pharmacology and Therapeutics
Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
AIMS: Although atrial fibrillation (AF) catheter ablation increases sinus heart rate (HR), its mechanism and prognosis have not yet been clearly elucidated. We hypothesize that post-AF ablation high sinus HR (PA-HSR) is associated with a better clinical outcome of AF ablation without adverse cardiac effects. METHODS AND RESULTS: We studied 991 AF patients (75% male, 58 ± 11 years old, 70% paroxysmal AF) with HR variability (HRV) at 3 months and 1 year after catheter ablation, and pre- and post-1-year echocardiograms...
June 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
2016-06-14 04:40:52
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