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Atrial Fibrillation

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35 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27705839/30-year-nationwide-trends-in-incidence-of-atrial-fibrillation-in-denmark-and-associated-5-year-risk-of-heart-failure-stroke-and-death
#1
Morten Schmidt, Sinna Pilgaard Ulrichsen, Lars Pedersen, Hans Erik Bøtker, Jens Cosedis Nielsen, Henrik Toft Sørensen
BACKGROUND: Long-term nationwide trends in atrial fibrillation (AF) incidence and 5-year outcomes are rare. METHODS: We conducted a population-based cohort study using the Danish National Patient Registry covering all Danish hospitals. We computed standardized incidence rates during 1983-2012. We used Cox regression to estimate hazard ratios (HRs) of heart failure, stroke, and death within 5years, comparing 5-year calendar periods with the earliest period (1983-1987) as reference...
December 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27825974/complexity-of-af-genetic-susceptibility-begets-complexity-of-interpretation
#2
EDITORIAL
Lee L Eckhardt, Jonathan C Makielski
No abstract text is available yet for this article.
November 4, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27725286/stabilizing-ryanodine-receptor-gating-quiets-arrhythmogenic-events-in-human-heart-failure-and-atrial-fibrillation
#3
Donald M Bers
No abstract text is available yet for this article.
October 7, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27746384/the-role-of-ranolazine-in-the-prevention-and-treatment-of-atrial-fibrillation-a-meta-analysis-of-randomized-clinical-trials
#4
Mengqi Gong, Zhiwei Zhang, Nikolaos Fragakis, Panagiotis Korantzopoulos, Konstantinos P Letsas, Guangping Li, Gan-Xin Yan, Tong Liu
BACKGROUND: Randomized controlled trials (RCTs) regarding use of ranolazine (RN) for the prevention and cardioversion of atrial fibrillation (AF) have yielded conflicting results. OBJECTIVE: we conducted a meta-analysis of RCTs to examine the potential role of RN in the prevention and cardioversion of AF. METHODS: PubMed and EMBASE were searched until June 2016. Of 484 initially identified studies, eight RCTs were finally analyzed. RESULTS: The analysis of RCTs showed that RN significantly reduced the incidence of AF compared to the control group in various clinical settings as following cardiac surgery, in acute coronary syndromes, and post electrical cardioversion of AF (RR = 0...
October 13, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27756707/unique-cardiomyocyte-ultrastructure-in-atria-role-of-t-tubules-in-subcellular-ca-2-signaling-and-atrial-arrhythmogenesis
#5
EDITORIAL
Dobromir Dobrev
No abstract text is available yet for this article.
October 15, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27756709/gain-of-function-mutations-in-gata6-lead-to-atrial-fibrillation
#6
Nathan R Tucker, Saagar Mahida, Jiangchuan Ye, Elizabeth J Abraham, Julie A Mina, Victoria A Parsons, Michael A McLellan, Marisa A Shea, Alan Hanley, Emelia J Benjamin, David J Milan, Honghuang Lin, Patrick T Ellinor
BACKGROUND: The genetic basis of atrial fibrillation (AF) and congenital heart disease remains incompletely understood. OBJECTIVE: We sought to determine the causative mutation in a family with AF, atrial septal and ventricular septal defects. METHODS: We evaluated a pedigree with 16 family members, one with an atrial septal defect, one with a ventricular septal defect and three with AF; we performed whole exome sequencing in three affected family members...
October 15, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27742809/a-frameshift-deletion-in-the-sarcomere-gene-myl4-causes-early-onset-familial-atrial-fibrillation
#7
Daniel F Gudbjartsson, Hilma Holm, Patrick Sulem, Gisli Masson, Asmundur Oddsson, Olafur Th Magnusson, Jona Saemundsdottir, Hafdis Th Helgadottir, Hannes Helgason, Hrefna Johannsdottir, Solveig Gretarsdottir, Sigurjon A Gudjonsson, Inger Njølstad, Maja-Lisa Løchen, Larry Baum, Ronald C W Ma, Gunnlaugur Sigfusson, Augustine Kong, Guðmundur Thorgeirsson, Jon Th Sverrisson, Unnur Thorsteinsdottir, Kari Stefansson, David O Arnar
AIMS: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in man, causing substantial morbidity and mortality with a major worldwide public health impact. It is increasingly recognized as a highly heritable condition. This study aimed to determine genetic risk factors for early-onset AF. METHODS AND RESULTS: We sequenced the whole genomes of 8453 Icelanders and imputed genotypes of the 25.5 million sequence variants we discovered into 1799 Icelanders with early-onset AF (diagnosed before 60 years of age) and 337 453 controls...
October 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27650424/antiarrhythmic-effects-of-dantrolene-in-human-diseased-cardiomyocytes
#8
Nico Hartmann, Steffen Pabel, Jonas Herting, Felix Schatter, André Renner, Jan Gummert, Hanna Schotola, Bernhard C Danner, Lars S Maier, Norbert Frey, Gerd Hasenfuss, Thomas H Fischer, Samuel Sossalla
BACKGROUND: Cardiac type 2 ryanodine receptors (RyR2s) play a pivotal role in cellular electrophysiology and contractility. Increased RyR2-mediated diastolic sarcoplasmic reticulum (SR) Ca(2+) release is linked to heart failure (HF) and arrhythmias. Dantrolene, a drug used for the treatment of malignant hyperthermia, is known to stabilize RyRs in skeletal muscle. OBJECTIVE: The purpose of this study was to investigate the effects of dantrolene on arrhythmogenic triggers and contractile function in human atrial fibrillation (AF) and HF cardiomyocytes (CM)...
September 17, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27651389/the-search-for-the-tipping-point-on-when-to-anticoagulate-patients-with-atrial-fibrillation
#9
Hein Heidbuchel
No abstract text is available yet for this article.
September 20, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27609430/2016-focused-update-of-the-canadian-cardiovascular-society-guidelines-for-the-management-of-atrial-fibrillation
#10
Laurent Macle, John Cairns, Kori Leblanc, Teresa Tsang, Allan Skanes, Jafna L Cox, Jeff S Healey, Alan Bell, Louise Pilote, Jason G Andrade, L Brent Mitchell, Clare Atzema, David Gladstone, Mike Sharma, Subodh Verma, Stuart Connolly, Paul Dorian, Ratika Parkash, Mario Talajic, Stanley Nattel, Atul Verma
The Canadian Cardiovascular Society (CCS) Atrial Fibrillation (AF) Guidelines Committee provides periodic reviews of new data to produce focused updates that address clinically important advances in AF management. This 2016 Focused Update deals with: (1) the management of antithrombotic therapy for AF patients in the context of the various clinical presentations of coronary artery disease; (2) real-life data with non-vitamin K antagonist oral anticoagulants; (3) the use of antidotes for the reversal of non-vitamin K antagonist oral anticoagulants; (4) digoxin as a rate control agent; (5) perioperative anticoagulation management; and (6) AF surgical therapy including the prevention and treatment of AF after cardiac surgery...
October 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27601603/pathophysiology-of-atrial-fibrillation-in-endurance-athletes-an-overview-of-recent-findings
#11
Fabian Sanchis-Gomar, Alejandro Lucia
No abstract text is available yet for this article.
September 6, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27567408/2016-esc-guidelines-for-the-management-of-atrial-fibrillation-developed-in-collaboration-with-eacts-the-task-force-for-the-management-of-atrial-fibrillation-of-the-european-society-of-cardiology-esc-developed-with-the-special-contribution-of-the-european-heart
#12
Paulus Kirchhof, Stefano Benussi, Dipak Kotecha, Anders Ahlsson, Dan Atar, Barbara Casadei, Manuel Castella, Hans-Christoph Diener, Hein Heidbuchel, Jeroen Hendriks, Gerhard Hindricks, Antonis S Manolis, Jonas Oldgren, Bogdan Alexandru Popescu, Ulrich Schotten, Bart Van Putte, Panagiotis Vardas
No abstract text is available yet for this article.
August 27, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27569443/balance-between-sodium-and-calcium-currents-underlying-chronic-atrial-fibrillation-termination-an-in-silico-intersubject-variability-study
#13
Alejandro Liberos, Alfonso Bueno-Orovio, Miguel Rodrigo, Ursula Ravens, Ismael Hernandez-Romero, Francisco Fernandez-Aviles, Maria S Guillem, Blanca Rodriguez, Andreu M Climent
BACKGROUND: Atrial remodeling as a result of long-standing persistent atrial fibrillation (AF) induces substrate modifications that lead to different perpetuation mechanisms than in paroxysmal AF and a reduction in the efficacy of antiarrhythmic treatments. OBJECTIVE: The purpose of this study was to identify the ionic current modifications that could destabilize reentries during chronic AF and serve to personalize antiarrhythmic strategies. METHODS: A population of 173 mathematical models of remodeled human atrial tissue with realistic intersubject variability was developed based on action potential recordings of 149 patients diagnosed with AF...
August 26, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27484715/prevalence-and-mechanism-of-rotor-activation-identified-during-atrial-fibrillation-by-noncontact-mapping-lack-of-evidence-for-a-role-in-the-maintenance-of-atrial-fibrillation
#14
Hiroshige Yamabe, Hisanori Kanazawa, Miwa Ito, Shozo Kaneko, Hisao Ogawa
BACKGROUND: It remains unclear whether atrial fibrillation (AF) is maintained by the rotor. OBJECTIVE: We evaluated the role of the rotor and examined its mechanism. METHODS: Among 75 patients with AF (60 paroxysmal, 15 persistent AF) who underwent 3-dimensional noncontact left atrial mapping during AF, we examined the prevalence and location of rotor activation and elucidated its mechanism. Catheter ablation was performed in a stepwise fashion (linear roof lesion and complex fractionated atrial electrogram ablation after pulmonary vein [PV) isolation) until AF termination...
July 30, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27462054/ablation-of-atrial-fibrillation-patient-selection-periprocedural-anticoagulation-techniques-and-preventive-measures-after-ablation
#15
Mark S Link, Michel Haïssaguerre, Andrea Natale
Atrial fibrillation (AF) is the most common arrhythmia encountered by cardiologists and is a major cause of morbidity and mortality. Risk factors for AF include age, male sex, genetic predisposition, hypertension, diabetes mellitus, sleep apnea, obesity, excessive alcohol, smoking, hyperthyroidism, pulmonary disease, air pollution, heart failure, and possibly excessive exercise. The management of AF involves decisions about rate versus rhythm control. Asymptomatic patients are generally managed with rate control and anticoagulation...
July 26, 2016: Circulation
https://www.readbyqxmd.com/read/27462069/adenosine-induced-atrial-fibrillation-localized-reentrant-drivers-in-lateral-right-atria-due-to-heterogeneous-expression-of-adenosine-a1-receptors-and-girk4-subunits-in-the-human-heart
#16
Ning Li, Thomas A Csepe, Brian J Hansen, Lidiya V Sul, Anuradha Kalyanasundaram, Stanislav O Zakharkin, Jichao Zhao, Avirup Guha, David R Van Wagoner, Ahmet Kilic, Peter J Mohler, Paul M L Janssen, Brandon J Biesiadecki, John D Hummel, Raul Weiss, Vadim V Fedorov
BACKGROUND: Adenosine provokes atrial fibrillation (AF) with a higher activation frequency in right atria (RA) versus left atria (LA) in patients, but the underlying molecular and functional substrates are unclear. We tested the hypothesis that adenosine-induced AF is driven by localized reentry in RA areas with highest expression of adenosine A1 receptor and its downstream GIRK (G protein-coupled inwardly rectifying potassium channels) channels (IK,Ado). METHODS: We applied biatrial optical mapping and immunoblot mapping of various atrial regions to reveal the mechanism of adenosine-induced AF in explanted failing and nonfailing human hearts (n=37)...
August 9, 2016: Circulation
https://www.readbyqxmd.com/read/26658575/comorbidity-of-atrial-fibrillation-and-heart-failure
#17
REVIEW
Liang-Han Ling, Peter M Kistler, Jonathan M Kalman, Richard J Schilling, Ross J Hunter
Atrial fibrillation (AF) and heart failure (HF) are evolving epidemics, together responsible for substantial human suffering and health-care expenditure. Ageing, improved cardiovascular survival, and epidemiological transition form the basis for their increasing global prevalence. Although we now have a clear picture of how HF promotes AF, gaps remain in our knowledge of how AF exacerbates or even causes HF, and how the development of HF affects the outcome of patients with AF. New data regarding HF with preserved ejection fraction and its unique relationship with AF suggest a possible role for AF in its aetiology, possibly as a trigger for ventricular fibrosis...
March 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27291509/atrial-fibrillation-in-inherited-cardiac-channelopathies-from-mechanisms-to-management
#18
Andres Enriquez, Charles Antzelevitch, Verdah Bismah, Adrian Baranchuk
Atrial fibrillation (AF) is prevalent in cardiac channelopathies and may be the presenting feature in some patients. The pathogenesis is related to the primary ion channel dysfunction in atrial myocytes that affects atrial conduction or repolarization. The development of AF is associated with adverse outcomes, and its management is challenging in these patients. In this article we review the current information on the prevalence, risk factors, pathophysiology, and treatment of AF in specific cardiac channelopathies...
September 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27389907/catheter-ablation-in-patients-with-persistent-atrial-fibrillation
#19
Paulus Kirchhof, Hugh Calkins
Catheter ablation is increasingly offered to patients who suffer from symptoms due to atrial fibrillation (AF), based on a growing body of evidence illustrating its efficacy compared with antiarrhythmic drug therapy. Approximately one-third of AF ablation procedures are currently performed in patients with persistent or long-standing persistent AF. Here, we review the available information to guide catheter ablation in these more chronic forms of AF. We identify the following principles: Our clinical ability to discriminate paroxysmal and persistent AF is limited...
July 7, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27381589/cryoballoon-or-radiofrequency-ablation-for-symptomatic-paroxysmal-atrial-fibrillation-reintervention-rehospitalization-and-quality-of-life-outcomes-in-the-fire-and-ice-trial
#20
Karl-Heinz Kuck, Alexander Fürnkranz, K R Julian Chun, Andreas Metzner, Feifan Ouyang, Michael Schlüter, Arif Elvan, Hae W Lim, Fred J Kueffer, Thomas Arentz, Jean-Paul Albenque, Claudio Tondo, Michael Kühne, Christian Sticherling, Josep Brugada
AIMS: The primary safety and efficacy endpoints of the randomized FIRE AND ICE trial have recently demonstrated non-inferiority of cryoballoon vs. radiofrequency current (RFC) catheter ablation in patients with drug-refractory symptomatic paroxysmal atrial fibrillation (AF). The aim of the current study was to assess outcome parameters that are important for the daily clinical management of patients using key secondary analyses. Specifically, reinterventions, rehospitalizations, and quality-of-life were examined in this randomized trial of cryoballoon vs...
July 5, 2016: European Heart Journal
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