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Atrial Fibrillation

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62 papers 25 to 100 followers
https://www.readbyqxmd.com/read/28784826/modifiable-risk-factors-and-atrial-fibrillation
#1
REVIEW
Dennis H Lau, Stanley Nattel, Jonathan M Kalman, Prashanthan Sanders
There has been increasing focus on the rising burden of atrial fibrillation (AF) since the turn of the millennium. The AF epidemic is projected not only to have an impact on morbidity and mortality, but also to result in increasing healthcare use and cost. Intensive research over the previous decades has improved our understanding of this complex arrhythmia while unraveling more knowledge gaps and inadequacies of current therapeutic options. Specifically, the advances in catheter ablation technology and strategies have not translated into significant gains in procedural success rates over recent years...
August 8, 2017: Circulation
https://www.readbyqxmd.com/read/28778856/correlates-of-arrhythmia-recurrence-after-hybrid-epi-and-endocardial-radiofrequency-ablation-for-persistent-atrial-fibrillation
#2
Alan Bulava, Ales Mokracek, Jiri Hanis, Martin Eisenberger, Vojtech Kurfirst, Ladislav Dusek
BACKGROUND: Long-term efficacy of catheter-based treatment of persistent atrial fibrillation is unsatisfactory. Minimally invasive surgical ablation techniques have been developed recently, but their efficacy has never been systematically tested. METHODS AND RESULTS: Seventy patients (median age, 63.5 years) with persistent atrial fibrillation underwent epicardial thoracoscopic radiofrequency pulmonary vein isolation, linear ablation, Marshal ligament disruption, and exclusion of the left atrial appendage...
August 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28784605/characterization-of-the-genetic-program-linked-to-the-development-of-atrial-fibrillation-in-crem-ib%C3%AE-c-x-mice
#3
Matthias D Seidl, Juliane Stein, Sabine Hamer, Florentina Pluteanu, Beatrix Scholz, Eva Wardelmann, Andreas Huge, Anika Witten, Monika Stoll, Elke Hammer, Uwe Völker, Frank U Müller
BACKGROUND: Reduced expression of genes regulated by the transcription factors CREB/CREM (cAMP response element-binding protein/modulator) is linked to atrial fibrillation (AF) susceptibility in patients. Cardiomyocyte-directed expression of the inhibitory CREM isoform CREM-IbΔC-X in transgenic mice (TG) leads to spontaneous-onset AF preceded by atrial dilatation and conduction abnormalities. Here, we characterized the altered gene program linked to atrial remodeling and development of AF in CREM-TG mice...
August 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28784606/genetic-genomic-insights-into-the-metabolic-determinants-of-spontaneous-atrial-fibrillation
#4
EDITORIAL
Shamone R Gore-Panter, Julie H Rennison, David R Van Wagoner
No abstract text is available yet for this article.
August 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28734984/germline-versus-somatic-mutations-in-genetic-atrial-fibrillation
#5
EDITORIAL
Mark McCauley, Dawood Darbar
No abstract text is available yet for this article.
July 20, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28682320/management-of-atrial-high-rate-episodes-detected-by-cardiac-implanted-electronic-devices
#6
REVIEW
Ben Freedman, Giuseppe Boriani, Taya V Glotzer, Jeff S Healey, Paulus Kirchhof, Tatjana S Potpara
Cardiac implanted electronic devices (CIEDs), including pacemakers and implantable defibrillators that perform atrial sensing typically using an atrial electrode, frequently detect subclinical atrial high-rate episodes (AHREs). When the intracardiac electrograms are carefully examined, the majority of AHREs are atrial fibrillation (AF) or other atrial tachyarrhythmias, which have been shown to be associated with both an increased risk of stroke, and subsequent development of clinical AF. However, the absolute risk of stroke among patients with AHREs is less than might be expected for clinically diagnosed paroxysmal AF...
July 6, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28629853/from-trailer-parks-to-the-human-atria-the-meandering-path-of-rotors
#7
EDITORIAL
Mohammed Saeed, Hakan Oral
No abstract text is available yet for this article.
June 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28637342/genetic-heterogeneity-of-atrial-fibrillation-susceptibility-loci-across-racial-or-ethnic-groups
#8
Henry Huang, Dawood Darbar
No abstract text is available yet for this article.
September 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28611206/pulmonary-vein-isolation-alone-versus-additional-linear-ablation-in-patients-with-persistent-atrial-fibrillation-converted-to-paroxysmal-type-with-antiarrhythmic-drug-therapy-a-multicenter-prospective-randomized-study
#9
RANDOMIZED CONTROLLED TRIAL
Hee Tae Yu, Jaemin Shim, Junbeom Park, In-Soo Kim, Tae-Hoon Kim, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Young-Hoon Kim, Hui-Nam Pak
BACKGROUND: Atrial fibrillation (AF) type can vary depending on condition and timing, and some patients who initially present with persistent AF may be changed to paroxysmal AF after antiarrhythmic drug medication and cardioversion. We investigated whether circumferential pulmonary vein isolation (CPVI) alone is an effective rhythm control strategy in patients with persistent AF to paroxysmal AF. METHODS AND RESULTS: We enrolled 113 patients with persistent AF to paroxysmal AF (male 75%, 60...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28611208/modifying-arrhythmia-behavior-preablation-with-drug-therapy-may-improve-single-procedure-efficacy-of-a-limited-ablation-strategy-in-patients-with-persistent-atrial-fibrillation
#10
EDITORIAL
Sanjay Dixit, Jackson J Liang, Rajeev K Pathak
No abstract text is available yet for this article.
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28504030/practical-recommendations-for-the-choice-of-anticoagulants-in-the-management-of-patients-with-atrial-fibrillation-on-ibrutinib
#11
Khai Li Chai, Gail Rowan, John F Seymour, Kate Burbury, Dennis Carney, Constantine S Tam
The management of AF represents a major challenge in patients with CLL, especially in elderly patients with multiple comorbidities who are representative of the majority of patients with CLL. This is especially complex in the case of ibrutinib. Many anticoagulants have potential for pharmacological interaction with ibrutinib, and ibrutinib itself has antiplatelet properties. Use of ibrutinib therapy in these patients mandates review and revision of the need for anticoagulation and best anticoagulant to use...
May 15, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28408329/highest-dominant-frequency-and-rotor-positions-are-robust-markers-of-driver-location-during-noninvasive-mapping-of-atrial-fibrillation-a-computational-study
#12
Miguel Rodrigo, Andreu M Climent, Alejandro Liberos, Francisco Fernández-Avilés, Omer Berenfeld, Felipe Atienza, Maria S Guillem
BACKGROUND: Dominant frequency (DF) and rotor mapping have been proposed as noninvasive techniques to guide localization of drivers maintaining atrial fibrillation (AF). OBJECTIVE: The purpose of this study was to evaluate the robustness of both techniques in identifying atrial drivers noninvasively under the effect of electrical noise or model uncertainties. METHODS: Inverse-computed DFs and phase maps were obtained from 30 different mathematical AF simulations...
August 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28383023/demystifying-rotors-and-their-place-in-clinical-translation-of-atrial-fibrillation-mechanisms
#13
REVIEW
Stanley Nattel, Feng Xiong, Martin Aguilar
Treatment of atrial fibrillation (AF), the most common arrhythmia in clinical practice, remains challenging. Improved understanding of underlying mechanisms is needed to improve therapy. Functional re-entry is central to AF maintenance. The first detailed, quantitative theory of functional re-entry, the 'leading circle' model, was developed 40 years ago. Subsequently, an alternative paradigm based on 'spiral waves' has evolved. Spiral-wave generators, or 'rotors', have been identified using advanced mapping methods in experimental and clinical AF...
September 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28375429/atrial-fibrillation-and-thrombo-embolism-anticoagulants-or-devices
#14
Thomas F Lüscher
No abstract text is available yet for this article.
March 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28262346/effective-suppression-of-atrial-fibrillation-by-ivabradine-novel-target-for-an-established-drug
#15
Gerrit Frommeyer, Magdalena Sterneberg, Dirk G Dechering, Christian Ellermann, Nils Bögeholz, Simon Kochhäuser, Christian Pott, Michael Fehr, Lars Eckardt
BACKGROUND: Ivabradine is an inhibitor of mixed Na(+)-K(+)-currents and routinely administered in chronic heart failure. Clinical studies reported divergent trends regarding proarrhythmic and antiarrhythmic effects in atrial fibrillation (AF). METHODS AND RESULTS: In 12 isolated rabbit hearts AF was induced in 7 of 12 hearts (13 episodes) under baseline conditions by a standardized protocol employing atrial burst pacing. Thereafter, a combination of acetylcholine and isoproterenol was employed to enhance AF occurrence...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28232263/progression-of-paroxysmal-to-persistent-atrial-fibrillation-canadian-registry-of-atrial-fibrillation-10-year-follow-up
#16
Gareth J Padfield, Christian Steinberg, Janice Swampillai, Hong Qian, Stuart J Connolly, Paul Dorian, Martin S Green, Karin H Humphries, George J Klein, Robert Sheldon, Mario Talajic, Charles R Kerr
BACKGROUND: Progression from paroxysmal to persistent atrial fibrillation (AF) has important clinical implications and is relevant to the management of patients with AF. OBJECTIVE: The purpose of this study was to define the long-term rate of progression from paroxysmal to persistent AF and the relevant clinical variables. METHODS: The Canadian Registry of Atrial Fibrillation enrolled patients after a first electrocardiographic diagnosis of paroxysmal AF...
February 21, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28228428/effect-of-aggressive-blood-pressure-control-on-the-recurrence-of-atrial-fibrillation-after-catheter-ablation-a-randomized-open-label-clinical-trial-smac-af-substrate-modification-with-aggressive-blood-pressure-control
#17
RANDOMIZED CONTROLLED TRIAL
Ratika Parkash, George A Wells, John L Sapp, Jeffrey S Healey, Jean-Claude Tardif, Isabelle Greiss, Lena Rivard, Jean-Francois Roux, Lorne Gula, Isabelle Nault, Paul Novak, David Birnie, Andrew Ha, Stephen B Wilton, Iqwal Mangat, Christopher Gray, Martin Gardner, Anthony S L Tang
BACKGROUND: Radiofrequency catheter ablation for atrial fibrillation has become an important therapy for AF; however, recurrence rates remain high. We proposed to determine whether aggressive blood pressure (BP) lowering prevents recurrent atrial fibrillation (AF) after catheter ablation in patients with AF and a high symptom burden. METHODS: We randomly assigned 184 patients with AF and a BP >130/80 mm Hg to aggressive BP (target <120/80 mm Hg) or standard BP (target <140/90 mm Hg) treatment before their scheduled AF catheter ablation...
May 9, 2017: Circulation
https://www.readbyqxmd.com/read/28185918/warfarin-use-and-the-risk-of-mortality-stroke-and-bleeding-in-hemodialysis-patients-with-atrial-fibrillation
#18
Brandon Kai, Yuliya Bogorad, Leigh-Anh N Nguyen, Su-Jau Yang, Wansu Chen, Hillard T Spencer, Albert Y-J Shen, Ming-Sum Lee
BACKGROUND: The optimal management of stroke prophylaxis in hemodialysis patients with atrial fibrillation is controversial. OBJECTIVE: The purpose of this study was to determine the risk of mortality, stroke, and bleeding associated with the use of warfarin in hemodialysis patients with atrial fibrillation. METHODS: This was a retrospective, population-based study of hemodialysis patients with atrial fibrillation between January 1, 2006, and September 30, 2015...
May 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28161513/the-burden-of-proof-the-current-state-of-atrial-fibrillation-prevention-and-treatment-trials
#19
Rosita Zakeri, David R Van Wagoner, Hugh Calkins, Tom Wong, Heather M Ross, E Kevin Heist, Timothy E Meyer, Peter R Kowey, Robert J Mentz, John G Cleland, Bertram Pitt, Faiez Zannad, Cecilia Linde
Atrial fibrillation (AF) is an age-related arrhythmia of enormous socioeconomic significance. In recent years, our understanding of the basic mechanisms that initiate and perpetuate AF has evolved rapidly, catheter ablation of AF has progressed from concept to reality, and recent studies suggest lifestyle modification may help prevent AF recurrence. Emerging developments in genetics, imaging, and informatics also present new opportunities for personalized care. However, considerable challenges remain. These include a paucity of studies examining AF prevention, modest efficacy of existing antiarrhythmic therapies, diverse ablation technologies and practice, and limited evidence to guide management of high-risk patients with multiple comorbidities...
May 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28166312/association-between-subclinical-cardiac-biomarkers-and-clinically-manifest-cardiac-diseases-with-cortical-cerebral-microinfarcts
#20
Saima Hilal, Yuek Ling Chai, Susanne van Veluw, Muhammad Amin Shaik, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Arthur Mark Richards, Geert Jan Biessels, Christopher Chen
Importance: Subclinical and clinical cardiac diseases have been previously linked to magnetic resonance imaging (MRI) manifestations of cerebrovascular disease, such as lacunes and white matter hyperintensities, as well as dementia. Cortical cerebral microinfarcts (CMIs), a novel MRI marker of cerebral vascular disease, have not been studied, to date, in relation to subclinical and clinical cardiac diseases. Objective: To examine the association of blood biomarkers of subclinical cardiac disease and clinically manifest cardiac diseases with CMIs graded on 3-T MRI in a memory clinic population...
April 1, 2017: JAMA Neurology
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