Kaycee M Sink, Gregory W Evans, Ronald I Shorr, Jeffrey T Bates, Dan Berlowitz, Molly B Conroy, Deborah M Felton, Tanya Gure, Karen C Johnson, Dalane Kitzman, Mary F Lyles, Karen Servilla, Mark A Supiano, Jeff Whittle, Alan Wiggers, Lawrence J Fine
OBJECTIVE: To determine predictors of serious adverse events (SAEs) involving syncope, hypotension, and falls, with particular attention to age, in the Systolic Blood Pressure Intervention Trial. DESIGN: Randomized clinical trial. SETTING: Academic and private practices across the United States (N = 102). PARTICIPANTS: Adults aged 50 and older with a systolic blood pressure (SBP) of 130 to 180 mmHg at high risk of cardiovascular disease events, but without diabetes, history of stroke, symptomatic heart failure or ejection fraction less than 35%, dementia, or standing SBP less than 110 mmHg (N = 9,361)...
April 2018: Journal of the American Geriatrics Society