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Rony Weiss Cognitive

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2 papers 0 to 25 followers
By Rony Weiss Geriatrician
Masako Tamaki, Ji Won Bang, Takeo Watanabe, Yuka Sasaki
We often experience troubled sleep in a novel environment [1]. This is called the first-night effect (FNE) in human sleep research and has been regarded as a typical sleep disturbance [2-4]. Here, we show that the FNE is a manifestation of one hemisphere being more vigilant than the other as a night watch to monitor unfamiliar surroundings during sleep [5, 6]. Using advanced neuroimaging techniques [7, 8] as well as polysomnography, we found that the temporary sleep disturbance in the first sleep experimental session involves regional interhemispheric asymmetry of sleep depth [9]...
May 9, 2016: Current Biology: CB
Maurice W Dysken, Mary Sano, Sanjay Asthana, Julia E Vertrees, Muralidhar Pallaki, Maria Llorente, Susan Love, Gerard D Schellenberg, J Riley McCarten, Julie Malphurs, Susana Prieto, Peijun Chen, David J Loreck, George Trapp, Rajbir S Bakshi, Jacobo E Mintzer, Judith L Heidebrink, Ana Vidal-Cardona, Lillian M Arroyo, Angel R Cruz, Sally Zachariah, Neil W Kowall, Mohit P Chopra, Suzanne Craft, Stephen Thielke, Carolyn L Turvey, Catherine Woodman, Kimberly A Monnell, Kimberly Gordon, Julie Tomaska, Yoav Segal, Peter N Peduzzi, Peter D Guarino
IMPORTANCE: Although vitamin E and memantine have been shown to have beneficial effects in moderately severe Alzheimer disease (AD), evidence is limited in mild to moderate AD. OBJECTIVE: To determine if vitamin E (alpha tocopherol), memantine, or both slow progression of mild to moderate AD in patients taking an acetylcholinesterase inhibitor. DESIGN, SETTING, AND PARTICIPANTS: Double-blind, placebo-controlled, parallel-group, randomized clinical trial involving 613 patients with mild to moderate AD initiated in August 2007 and concluded in September 2012 at 14 Veterans Affairs medical centers...
January 1, 2014: JAMA: the Journal of the American Medical Association
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