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Oncology Rony

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3 papers 0 to 25 followers
By Rony Weiss Geriatrician
Matjaz Zwitter, Mirjana Rajer, Karmen Stanic, Martina Vrankar, Andrej Doma, Anka Cuderman, Marko Grmek, Izidor Kern, Viljem Kovac
Among attempts to delay development of resistance to tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC) with activating mutations of epidermal growth factor receptor (EGFR), intercalated therapy has not been properly evaluated. In a phase II trial, 38 patients with EGFR mutated NSCLC in advanced stage were treated with 4 to 6 3-weekly cycles of intercalated schedule with gemcitabine (1250 mg/m2, days 1 and 4), cisplatin (75 mg/m2, day 2) and erlotinib (150 mg, days 5 - 15), followed by continuous erlotinib as maintenance...
August 2, 2016: Cancer Biology & Therapy
Davendra P S Sohal, Pamela B Mangu, Alok A Khorana, Manish A Shah, Philip A Philip, Eileen M O'Reilly, Hope E Uronis, Ramesh K Ramanathan, Christopher H Crane, Anitra Engebretson, Joseph T Ruggiero, Mehmet S Copur, Michelle Lau, Susan Urba, Daniel Laheru
PURPOSE: To provide evidence-based recommendations to oncologists and others for the treatment of patients with metastatic pancreatic cancer. METHODS: American Society of Clinical Oncology convened an Expert Panel of medical oncology, radiation oncology, surgical oncology, gastroenterology, palliative care, and advocacy experts to conduct a systematic review of the literature from April 2004 to June 2015. Outcomes were overall survival, disease-free survival, progression-free survival, and adverse events...
August 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Thomas R Pisanic, Pornpat Athamanolap, Weijie Poh, Chen Chen, Alicia Hulbert, Malcolm V Brock, James G Herman, Tza-Huei Wang
Many cancers comprise heterogeneous populations of cells at primary and metastatic sites throughout the body. The presence or emergence of distinct subclones with drug-resistant genetic and epigenetic phenotypes within these populations can greatly complicate therapeutic intervention. Liquid biopsies of peripheral blood from cancer patients have been suggested as an ideal means of sampling intratumor genetic and epigenetic heterogeneity for diagnostics, monitoring and therapeutic guidance. However, current molecular diagnostic and sequencing methods are not well suited to the routine assessment of epigenetic heterogeneity in difficult samples such as liquid biopsies that contain intrinsically low fractional concentrations of circulating tumor DNA (ctDNA) and rare epigenetic subclonal populations...
December 15, 2015: Nucleic Acids Research
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