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Palliative Rony

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4 papers 0 to 25 followers
By Rony Weiss Geriatrician
https://www.readbyqxmd.com/read/29226044/neuroanatomy-and-neuropsychology-of-pain
#1
REVIEW
Shehzad Khalid, R Shane Tubbs
We have reviewed here the neuroanatomical and neuropsychological literature of the human brain and have proposed the various pain mechanisms that we currently know of. Essentially when tissue is damaged, peripheral nociceptors are activated continuously and prostanoids are hence produced. Nonsteroidal anti-inflammatory drugs (NSAIDs) and medications aim to target these prostanoids to treat the inflammatory component of pain. Normal pain tends to have a protective response. It is important for the nervous system to learn and recognize this painful stimulus earlier and quicker with repeated exposure to avoid tissue damage...
October 6, 2017: Curēus
https://www.readbyqxmd.com/read/26017825/case-records-of-the-massachusetts-general-hospital-case-17-2015-a-44-year-old-woman-with-intractable-pain-due-to-metastatic-lung-cancer
#2
Mihir M Kamdar, Kathleen P Doyle, Lecia V Sequist, Todd J Rinehart, Guy Maytal, Efren J Flores, Mari Mino-Kenudson
Presentation of Case. Dr. Lecia V. Sequist: A 44-year-old woman with metastatic (stage IV) non–small-cell lung carcinoma was seen in the outpatient cancer center of this hospital because of intractable pain. The patient had been well until approximately 1 year before this evaluation, when pain in..
May 28, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/23556990/the-use-of-very-low-dose-methadone-for-palliative-pain-control-and-the-prevention-of-opioid-hyperalgesia
#3
Shelley R Salpeter, Jacob S Buckley, Eduardo Bruera
BACKGROUND: Opioid dose escalation may cause hyperalgesia, mediated by the N-methyl-D-aspartate (NMDA) pathway. Methadone is an atypical opioid that inhibits hyperalgesia through NMDA-blockade, especially at low doses. OBJECTIVE: To evaluate the efficacy of using very-low-dose methadone as the sole long-acting opioid agent in a hospice practice. DESIGN: A retrospective, observational study of the use of methadone, ≤15 mg daily, with as-needed short-acting opiates...
June 2013: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/20818875/early-palliative-care-for-patients-with-metastatic-non-small-cell-lung-cancer
#4
RANDOMIZED CONTROLLED TRIAL
Jennifer S Temel, Joseph A Greer, Alona Muzikansky, Emily R Gallagher, Sonal Admane, Vicki A Jackson, Constance M Dahlin, Craig D Blinderman, Juliet Jacobsen, William F Pirl, J Andrew Billings, Thomas J Lynch
BACKGROUND: Patients with metastatic non-small-cell lung cancer have a substantial symptom burden and may receive aggressive care at the end of life. We examined the effect of introducing palliative care early after diagnosis on patient-reported outcomes and end-of-life care among ambulatory patients with newly diagnosed disease. METHODS: We randomly assigned patients with newly diagnosed metastatic non-small-cell lung cancer to receive either early palliative care integrated with standard oncologic care or standard oncologic care alone...
August 19, 2010: New England Journal of Medicine
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