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Rony Weiss Palliative

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3 papers 0 to 25 followers
By Rony Weiss Geriatrician
https://www.readbyqxmd.com/read/26017825/case-records-of-the-massachusetts-general-hospital-case-17-2015-a-44-year-old-woman-with-intractable-pain-due-to-metastatic-lung-cancer
#1
Mihir M Kamdar, Kathleen P Doyle, Lecia V Sequist, Todd J Rinehart, Guy Maytal, Efren J Flores, Mari Mino-Kenudson
Presentation of Case. Dr. Lecia V. Sequist: A 44-year-old woman with metastatic (stage IV) non–small-cell lung carcinoma was seen in the outpatient cancer center of this hospital because of intractable pain. The patient had been well until approximately 1 year before this evaluation, when pain in..
May 28, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/23556990/the-use-of-very-low-dose-methadone-for-palliative-pain-control-and-the-prevention-of-opioid-hyperalgesia
#2
Shelley R Salpeter, Jacob S Buckley, Eduardo Bruera
BACKGROUND: Opioid dose escalation may cause hyperalgesia, mediated by the N-methyl-D-aspartate (NMDA) pathway. Methadone is an atypical opioid that inhibits hyperalgesia through NMDA-blockade, especially at low doses. OBJECTIVE: To evaluate the efficacy of using very-low-dose methadone as the sole long-acting opioid agent in a hospice practice. DESIGN: A retrospective, observational study of the use of methadone, ≤15 mg daily, with as-needed short-acting opiates...
June 2013: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/20818875/early-palliative-care-for-patients-with-metastatic-non-small-cell-lung-cancer
#3
RANDOMIZED CONTROLLED TRIAL
Jennifer S Temel, Joseph A Greer, Alona Muzikansky, Emily R Gallagher, Sonal Admane, Vicki A Jackson, Constance M Dahlin, Craig D Blinderman, Juliet Jacobsen, William F Pirl, J Andrew Billings, Thomas J Lynch
BACKGROUND: Patients with metastatic non-small-cell lung cancer have a substantial symptom burden and may receive aggressive care at the end of life. We examined the effect of introducing palliative care early after diagnosis on patient-reported outcomes and end-of-life care among ambulatory patients with newly diagnosed disease. METHODS: We randomly assigned patients with newly diagnosed metastatic non-small-cell lung cancer to receive either early palliative care integrated with standard oncologic care or standard oncologic care alone...
August 19, 2010: New England Journal of Medicine
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