Kenneth W Lyles, Cathleen S Colón-Emeric, Jay S Magaziner, Jonathan D Adachi, Carl F Pieper, Carlos Mautalen, Lars Hyldstrup, Chris Recknor, Lars Nordsletten, Kathy A Moore, Catherine Lavecchia, Jie Zhang, Peter Mesenbrink, Patricia K Hodgson, Ken Abrams, John J Orloff, Zebulun Horowitz, Erik Fink Eriksen, Steven Boonen
BACKGROUND: Mortality is increased after a hip fracture, and strategies that improve outcomes are needed. METHODS: In this randomized, double-blind, placebo-controlled trial, 1065 patients were assigned to receive yearly intravenous zoledronic acid (at a dose of 5 mg), and 1062 patients were assigned to receive placebo. The infusions were first administered within 90 days after surgical repair of a hip fracture. All patients (mean age, 74.5 years) received supplemental vitamin D and calcium...
November 1, 2007: New England Journal of Medicine