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RPHICUTeaching2016.1-Transfusion and Coagulation

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5 papers 0 to 25 followers Research Papers used in aid of the in-house ICU registrar teaching programme at Royal Perth Hospital in the first half of 2016.
Alejandro Lazo-Langner, Eddy S Lang, James Douketis
New oral anticoagulants, including dabigatran, rivaroxaban, and apixaban, have been recently approved for primary and secondary prophylaxis of thromboembolic conditions. However, there is no clear strategy for managing and reversing their anticoagulant effects. We aimed to summarize the available evidence for clinical management and reversal of bleeding associated with new oral anticoagulants. Using a systematic review approach, we aimed to identify studies describing reversal strategies for dabigatran, rivaroxaban, and apixaban...
June 17, 2013: Critical Care: the Official Journal of the Critical Care Forum
Todd H Baron, Patrick S Kamath, Robert D McBane
No abstract text is available yet for this article.
May 30, 2013: New England Journal of Medicine
Daryl J Kor, Ognjen Gajic
PURPOSE OF REVIEW: The past two decades have witnessed an extensive re-evaluation of transfusion therapy in the intensive care unit (ICU). The purpose of this review is to present the current state of knowledge regarding blood transfusion in the critically ill and to identify gaps in our current understanding for future research. RECENT FINDINGS: Accumulating evidence suggests a lack of efficacy with red blood cell (RBC), plasma, and platelet transfusion in the majority of critically ill patients...
August 2010: Current Opinion in Critical Care
Jeremy G Perkins, Andrew P Cap, Brendan M Weiss, Thomas J Reid, Charles D Bolan, Charles E Bolan
BACKGROUND: Hemorrhage in trauma is a significant challenge, accounting for 30% to 40% of all fatalities, second only to central nervous system injury as a cause of death. However, hemorrhagic death is the leading preventable cause of mortality in combat casualties and typically occurs within 6 to 24 hrs of injury. In cases of severe hemorrhage, massive transfusion may be required to replace more than the entire blood volume. Early prediction of massive transfusion requirements, using clinical and laboratory parameters, combined with aggressive management of hemorrhage by surgical and nonsurgical means, has significant potential to reduce early mortality...
July 2008: Critical Care Medicine
P C H├ębert, G Wells, M A Blajchman, J Marshall, C Martin, G Pagliarello, M Tweeddale, I Schweitzer, E Yetisir
BACKGROUND: To determine whether a restrictive strategy of red-cell transfusion and a liberal strategy produced equivalent results in critically ill patients, we compared the rates of death from all causes at 30 days and the severity of organ dysfunction. METHODS: We enrolled 838 critically ill patients with euvolemia after initial treatment who had hemoglobin concentrations of less than 9.0 g per deciliter within 72 hours after admission to the intensive care unit and randomly assigned 418 patients to a restrictive strategy of transfusion, in which red cells were transfused if the hemoglobin concentration dropped below 7...
February 11, 1999: New England Journal of Medicine
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