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RPHICUTeaching2016.1-Renal Replacement Therapy

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7 papers 0 to 25 followers Research Papers used in aid of the in-house ICU registrar teaching programme at Royal Perth Hospital in the first half of 2016.
https://www.readbyqxmd.com/read/23268665/continuous-renal-replacement-therapy-for-acute-kidney-injury
#1
REVIEW
Ashita Tolwani
No abstract text is available yet for this article.
December 27, 2012: New England Journal of Medicine
https://www.readbyqxmd.com/read/21672279/clinical-review-timing-of-renal-replacement-therapy
#2
REVIEW
Michael Joannidis, Lui G Forni
Acute kidney injury is common in intensive care patients and continuous renal replacement therapy is the preferred treatment for this in most centres. Although these techniques have been adopted internationally, there remains significant variation with regard to their clinical application. This is particularly pertinent when one considers that the fundamental questions regarding any treatment, such as initiation, dose and length of treatment, remain a source of debate and have not as yet all been fully answered...
2011: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/21489322/clinical-review-optimal-dose-of-continuous-renal-replacement-therapy-in-acute-kidney-injury
#3
REVIEW
John R Prowle, Antoine Schneider, Rinaldo Bellomo
Continuous renal replacement therapy (CRRT) is the preferred treatment for acute kidney injury in intensive care units (ICUs) throughout much of the world. Despite the widespread use of CRRT, controversy and center-specific practice variation in the clinical application of CRRT continue. In particular, whereas two single-center studies have suggested survival benefit from delivery of higher-intensity CRRT to patients with acute kidney injury in the ICU, other studies have been inconsistent in their results...
2011: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/21345279/clinical-review-anticoagulation-for-continuous-renal-replacement-therapy-heparin-or-citrate
#4
REVIEW
Heleen M Oudemans-van Straaten, John A Kellum, Rinaldo Bellomo
Heparin is the most commonly prescribed anticoagulant for continuous renal replacement therapy. There is, however, increasing evidence questioning its safety, particularly in the critically ill. Heparin mainly confers its anticoagulant effect by binding to antithrombin. Heparin binds to numerous other proteins and cells as well, however, compromising its efficacy and safety. Owing to antithrombin consumption and degradation, and to the binding of heparin to acute phase proteins, and to apoptotic and necrotic cells, critical illness confers heparin resistance...
2011: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/19846848/intensity-of-continuous-renal-replacement-therapy-in-critically-ill-patients
#5
RANDOMIZED CONTROLLED TRIAL
Rinaldo Bellomo, Alan Cass, Louise Cole, Simon Finfer, Martin Gallagher, Serigne Lo, Colin McArthur, Shay McGuinness, John Myburgh, Robyn Norton, Carlos Scheinkestel, Steve Su
BACKGROUND: The optimal intensity of continuous renal-replacement therapy remains unclear. We conducted a multicenter, randomized trial to compare the effect of this therapy, delivered at two different levels of intensity, on 90-day mortality among critically ill patients with acute kidney injury. METHODS: We randomly assigned critically ill adults with acute kidney injury to continuous renal-replacement therapy in the form of postdilution continuous venovenous hemodiafiltration with an effluent flow of either 40 ml per kilogram of body weight per hour (higher intensity) or 25 ml per kilogram per hour (lower intensity)...
October 22, 2009: New England Journal of Medicine
https://www.readbyqxmd.com/read/19426417/anticoagulation-for-continuous-renal-replacement-therapy
#6
REVIEW
Ashita J Tolwani, Keith M Wille
Continuous renal replacement therapy (CRRT) has emerged as the preferred dialysis modality for critically ill patients with acute kidney injury, particularly those with hemodynamic instability. Anticoagulation is necessary for effective delivery of CRRT, but this requirement can also present challenges, as many critically ill patients with sepsis and inflammation already have a higher risk of bleeding as well as clotting. Without anticoagulation, CRRT filter and circuit survival are diminished, and therapy becomes less helpful...
March 2009: Seminars in Dialysis
https://www.readbyqxmd.com/read/18492867/intensity-of-renal-support-in-critically-ill-patients-with-acute-kidney-injury
#7
RANDOMIZED CONTROLLED TRIAL
Paul M Palevsky, Jane Hongyuan Zhang, Theresa Z O'Connor, Glenn M Chertow, Susan T Crowley, Devasmita Choudhury, Kevin Finkel, John A Kellum, Emil Paganini, Roland M H Schein, Mark W Smith, Kathleen M Swanson, B Taylor Thompson, Anitha Vijayan, Suzanne Watnick, Robert A Star, Peter Peduzzi
BACKGROUND: The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial. METHODS: We randomly assigned critically ill patients with acute kidney injury and failure of at least one nonrenal organ or sepsis to receive intensive or less intensive renal-replacement therapy. The primary end point was death from any cause by day 60. In both study groups, hemodynamically stable patients underwent intermittent hemodialysis, and hemodynamically unstable patients underwent continuous venovenous hemodiafiltration or sustained low-efficiency dialysis...
July 3, 2008: New England Journal of Medicine
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