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10 papers 0 to 25 followers Research Papers used in aid of the in-house ICU registrar teaching programme at Royal Perth Hospital in the first half of 2016.
Gordon S Doig, Fiona Simpson, Elizabeth A Sweetman, Simon R Finfer, D Jamie Cooper, Philippa T Heighes, Andrew R Davies, Michael O'Leary, Tom Solano, Sandra Peake
IMPORTANCE: Systematic reviews suggest adult patients in intensive care units (ICUs) with relative contraindications to early enteral nutrition (EN) may benefit from parenteral nutrition (PN) provided within 24 hours of ICU admission. OBJECTIVE: To determine whether providing early PN to critically ill adults with relative contraindications to early EN alters outcomes. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, randomized, single-blind clinical trial conducted between October 2006 and June 2011 in ICUs of 31 community and tertiary hospitals in Australia and New Zealand...
May 22, 2013: JAMA: the Journal of the American Medical Association
Juan B Ochoa Gautier, Flávia R Machado
No abstract text is available yet for this article.
May 22, 2013: JAMA: the Journal of the American Medical Association
Daren Heyland, John Muscedere, Paul E Wischmeyer, Deborah Cook, Gwynne Jones, Martin Albert, Gunnar Elke, Mette M Berger, Andrew G Day
BACKGROUND: Critically ill patients have considerable oxidative stress. Glutamine and antioxidant supplementation may offer therapeutic benefit, although current data are conflicting. METHODS: In this blinded 2-by-2 factorial trial, we randomly assigned 1223 critically ill adults in 40 intensive care units (ICUs) in Canada, the United States, and Europe who had multiorgan failure and were receiving mechanical ventilation to receive supplements of glutamine, antioxidants, both, or placebo...
April 18, 2013: New England Journal of Medicine
Simon Finfer, Bette Liu, Dean R Chittock, Robyn Norton, John A Myburgh, Colin McArthur, Imogen Mitchell, Denise Foster, Vinay Dhingra, William R Henderson, Juan J Ronco, Rinaldo Bellomo, Deborah Cook, Ellen McDonald, Peter Dodek, Paul C Hébert, Daren K Heyland, Bruce G Robinson
BACKGROUND: Whether hypoglycemia leads to death in critically ill patients is unclear. METHODS: We examined the associations between moderate and severe hypoglycemia (blood glucose, 41 to 70 mg per deciliter [2.3 to 3.9 mmol per liter] and ≤40 mg per deciliter [2.2 mmol per liter], respectively) and death among 6026 critically ill patients in intensive care units (ICUs). Patients were randomly assigned to intensive or conventional glucose control. We used Cox regression analysis with adjustment for treatment assignment and for baseline and postrandomization covariates...
September 20, 2012: New England Journal of Medicine
Michael P Casaer, Dieter Mesotten, Greet Hermans, Pieter J Wouters, Miet Schetz, Geert Meyfroidt, Sophie Van Cromphaut, Catherine Ingels, Philippe Meersseman, Jan Muller, Dirk Vlasselaers, Yves Debaveye, Lars Desmet, Jasperina Dubois, Aime Van Assche, Simon Vanderheyden, Alexander Wilmer, Greet Van den Berghe
BACKGROUND: Controversy exists about the timing of the initiation of parenteral nutrition in critically ill adults in whom caloric targets cannot be met by enteral nutrition alone. METHODS: In this randomized, multicenter trial, we compared early initiation of parenteral nutrition (European guidelines) with late initiation (American and Canadian guidelines) in adults in the intensive care unit (ICU) to supplement insufficient enteral nutrition. In 2312 patients, parenteral nutrition was initiated within 48 hours after ICU admission (early-initiation group), whereas in 2328 patients, parenteral nutrition was not initiated before day 8 (late-initiation group)...
August 11, 2011: New England Journal of Medicine
Brian P Kavanagh, Karen C McCowen
No abstract text is available yet for this article.
December 23, 2010: New England Journal of Medicine
Matthew C Byrnes, Jessica Stangenes
PURPOSE OF REVIEW: To describe the etiology and complications of the refeeding syndrome. RECENT FINDINGS: Complications of the refeeding syndrome can include electrolyte abnormalities, heart failure, respiratory failure, and death. This syndrome is of particular importance to critically ill patients, who can be moved from the starved state to the fed state rapidly via enteral or parenteral nutrition. There are a variety of risk factors for the development of the refeeding syndrome...
March 2011: Current Opinion in Clinical Nutrition and Metabolic Care
Thomas R Ziegler
No abstract text is available yet for this article.
September 10, 2009: New England Journal of Medicine
Robert G Martindale, Stephen A McClave, Vincent W Vanek, Mary McCarthy, Pamela Roberts, Beth Taylor, Juan B Ochoa, Lena Napolitano, Gail Cresci
No abstract text is available yet for this article.
May 2009: Critical Care Medicine
Simon Finfer, Dean R Chittock, Steve Yu-Shuo Su, Deborah Blair, Denise Foster, Vinay Dhingra, Rinaldo Bellomo, Deborah Cook, Peter Dodek, William R Henderson, Paul C Hébert, Stephane Heritier, Daren K Heyland, Colin McArthur, Ellen McDonald, Imogen Mitchell, John A Myburgh, Robyn Norton, Julie Potter, Bruce G Robinson, Juan J Ronco
BACKGROUND: The optimal target range for blood glucose in critically ill patients remains unclear. METHODS: Within 24 hours after admission to an intensive care unit (ICU), adults who were expected to require treatment in the ICU on 3 or more consecutive days were randomly assigned to undergo either intensive glucose control, with a target blood glucose range of 81 to 108 mg per deciliter (4.5 to 6.0 mmol per liter), or conventional glucose control, with a target of 180 mg or less per deciliter (10...
March 26, 2009: New England Journal of Medicine
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