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RPHICUTeaching2016.1-Haemodynamic Support

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11 papers 0 to 25 followers Research Papers used in aid of the in-house ICU registrar teaching programme at Royal Perth Hospital in the first half of 2016.
https://www.readbyqxmd.com/read/24635772/albumin-replacement-in-patients-with-severe-sepsis-or-septic-shock
#1
RANDOMIZED CONTROLLED TRIAL
Pietro Caironi, Gianni Tognoni, Serge Masson, Roberto Fumagalli, Antonio Pesenti, Marilena Romero, Caterina Fanizza, Luisa Caspani, Stefano Faenza, Giacomo Grasselli, Gaetano Iapichino, Massimo Antonelli, Vieri Parrini, Gilberto Fiore, Roberto Latini, Luciano Gattinoni
BACKGROUND: Although previous studies have suggested the potential advantages of albumin administration in patients with severe sepsis, its efficacy has not been fully established. METHODS: In this multicenter, open-label trial, we randomly assigned 1818 patients with severe sepsis, in 100 intensive care units (ICUs), to receive either 20% albumin and crystalloid solution or crystalloid solution alone. In the albumin group, the target serum albumin concentration was 30 g per liter or more until discharge from the ICU or 28 days after randomization...
April 10, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/24171518/circulatory-shock
#2
REVIEW
Jean-Louis Vincent, Daniel De Backer
New England Journal of Medicine, Volume 369, Issue 18, Page 1726-1734, October 2013.
October 31, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/24066745/resuscitation-fluids
#3
REVIEW
John A Myburgh, Michael G Mythen
New England Journal of Medicine, Volume 369, Issue 13, Page 1243-1251, September 2013.
September 26, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/23075127/hydroxyethyl-starch-or-saline-for-fluid-resuscitation-in-intensive-care
#4
RANDOMIZED CONTROLLED TRIAL
John A Myburgh, Simon Finfer, Rinaldo Bellomo, Laurent Billot, Alan Cass, David Gattas, Parisa Glass, Jeffrey Lipman, Bette Liu, Colin McArthur, Shay McGuinness, Dorrilyn Rajbhandari, Colman B Taylor, Steven A R Webb
BACKGROUND: The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have not been fully evaluated, and adverse effects of HES on survival and renal function have been reported. METHODS: We randomly assigned 7000 patients who had been admitted to an intensive care unit (ICU) in a 1:1 ratio to receive either 6% HES with a molecular weight of 130 kD and a molar substitution ratio of 0.4 (130/0.4, Voluven) in 0.9% sodium chloride or 0.9% sodium chloride (saline) for all fluid resuscitation until ICU discharge, death, or 90 days after randomization...
November 15, 2012: New England Journal of Medicine
https://www.readbyqxmd.com/read/21740415/use-of-inotropes-and-vasopressor-agents-in-critically-ill-patients
#5
REVIEW
Mansoor N Bangash, Ming-Li Kong, Rupert M Pearse
Inotropes and vasopressors are biologically and clinically important compounds that originate from different pharmacological groups and act at some of the most fundamental receptor and signal transduction systems in the body. More than 20 such agents are in common clinical use, yet few reviews of their pharmacology exist outside of physiology and pharmacology textbooks. Despite widespread use in critically ill patients, understanding of the clinical effects of these drugs in pathological states is poor. The purpose of this article is to describe the pharmacology and clinical applications of inotropic and vasopressor agents in critically ill patients...
April 2012: British Journal of Pharmacology
https://www.readbyqxmd.com/read/21615299/mortality-after-fluid-bolus-in-african-children-with-severe-infection
#6
RANDOMIZED CONTROLLED TRIAL
Kathryn Maitland, Sarah Kiguli, Robert O Opoka, Charles Engoru, Peter Olupot-Olupot, Samuel O Akech, Richard Nyeko, George Mtove, Hugh Reyburn, Trudie Lang, Bernadette Brent, Jennifer A Evans, James K Tibenderana, Jane Crawley, Elizabeth C Russell, Michael Levin, Abdel G Babiker, Diana M Gibb
BACKGROUND: The role of fluid resuscitation in the treatment of children with shock and life-threatening infections who live in resource-limited settings is not established. METHODS: We randomly assigned children with severe febrile illness and impaired perfusion to receive boluses of 20 to 40 ml of 5% albumin solution (albumin-bolus group) or 0.9% saline solution (saline-bolus group) per kilogram of body weight or no bolus (control group) at the time of admission to a hospital in Uganda, Kenya, or Tanzania (stratum A); children with severe hypotension were randomly assigned to one of the bolus groups only (stratum B)...
June 30, 2011: New England Journal of Medicine
https://www.readbyqxmd.com/read/20858239/pulmonary-vascular-and-right-ventricular-dysfunction-in-adult-critical-care-current-and-emerging-options-for-management-a-systematic-literature-review
#7
REVIEW
Laura C Price, Stephen J Wort, Simon J Finney, Philip S Marino, Stephen J Brett
INTRODUCTION: Pulmonary vascular dysfunction, pulmonary hypertension (PH), and resulting right ventricular (RV) failure occur in many critical illnesses and may be associated with a worse prognosis. PH and RV failure may be difficult to manage: principles include maintenance of appropriate RV preload, augmentation of RV function, and reduction of RV afterload by lowering pulmonary vascular resistance (PVR). We therefore provide a detailed update on the management of PH and RV failure in adult critical care...
2010: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/20200382/comparison-of-dopamine-and-norepinephrine-in-the-treatment-of-shock
#8
RANDOMIZED CONTROLLED TRIAL
Daniel De Backer, Patrick Biston, Jacques Devriendt, Christian Madl, Didier Chochrad, Cesar Aldecoa, Alexandre Brasseur, Pierre Defrance, Philippe Gottignies, Jean-Louis Vincent
BACKGROUND: Both dopamine and norepinephrine are recommended as first-line vasopressor agents in the treatment of shock. There is a continuing controversy about whether one agent is superior to the other. METHODS: In this multicenter, randomized trial, we assigned patients with shock to receive either dopamine or norepinephrine as first-line vasopressor therapy to restore and maintain blood pressure. When blood pressure could not be maintained with a dose of 20 microg per kilogram of body weight per minute for dopamine or a dose of 0...
March 4, 2010: New England Journal of Medicine
https://www.readbyqxmd.com/read/18765387/inotropes-and-vasopressors-review-of-physiology-and-clinical-use-in-cardiovascular-disease
#9
REVIEW
Christopher B Overgaard, Vladimír Dzavík
No abstract text is available yet for this article.
September 2, 2008: Circulation
https://www.readbyqxmd.com/read/18305265/vasopressin-versus-norepinephrine-infusion-in-patients-with-septic-shock
#10
RANDOMIZED CONTROLLED TRIAL
James A Russell, Keith R Walley, Joel Singer, Anthony C Gordon, Paul C Hébert, D James Cooper, Cheryl L Holmes, Sangeeta Mehta, John T Granton, Michelle M Storms, Deborah J Cook, Jeffrey J Presneill, Dieter Ayers
BACKGROUND: Vasopressin is commonly used as an adjunct to catecholamines to support blood pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors. METHODS: In this multicenter, randomized, double-blind trial, we assigned patients who had septic shock and were receiving a minimum of 5 microg of norepinephrine per minute to receive either low-dose vasopressin (0...
February 28, 2008: New England Journal of Medicine
https://www.readbyqxmd.com/read/15163774/a-comparison-of-albumin-and-saline-for-fluid-resuscitation-in-the-intensive-care-unit
#11
RANDOMIZED CONTROLLED TRIAL
Simon Finfer, Rinaldo Bellomo, Neil Boyce, Julie French, John Myburgh, Robyn Norton
BACKGROUND: It remains uncertain whether the choice of resuscitation fluid for patients in intensive care units (ICUs) affects survival. We conducted a multicenter, randomized, double-blind trial to compare the effect of fluid resuscitation with albumin or saline on mortality in a heterogeneous population of patients in the ICU. METHODS: We randomly assigned patients who had been admitted to the ICU to receive either 4 percent albumin or normal saline for intravascular-fluid resuscitation during the next 28 days...
May 27, 2004: New England Journal of Medicine
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