Pierre-Yves Gueugniaud, Jean-Stéphane David, Eric Chanzy, Hervé Hubert, Pierre-Yves Dubien, Patrick Mauriaucourt, Coralie Bragança, Xavier Billères, Marie-Paule Clotteau-Lambert, Patrick Fuster, Didier Thiercelin, Guillaume Debaty, Agnès Ricard-Hibon, Patrick Roux, Catherine Espesson, Emgan Querellou, Laurent Ducros, Patrick Ecollan, Laurent Halbout, Dominique Savary, Frédéric Guillaumée, Régine Maupoint, Philippe Capelle, Cécile Bracq, Philippe Dreyfus, Philippe Nouguier, Antoine Gache, Claude Meurisse, Bertrand Boulanger, Claude Lae, Jacques Metzger, Valérie Raphael, Arielle Beruben, Volker Wenzel, Comlavi Guinhouya, Christian Vilhelm, Emmanuel Marret
BACKGROUND: During the administration of advanced cardiac life support for resuscitation from cardiac arrest, a combination of vasopressin and epinephrine may be more effective than epinephrine or vasopressin alone, but evidence is insufficient to make clinical recommendations. METHODS: In a multicenter study, we randomly assigned adults with out-of-hospital cardiac arrest to receive successive injections of either 1 mg of epinephrine and 40 IU of vasopressin or 1 mg of epinephrine and saline placebo, followed by administration of the same combination of study drugs if spontaneous circulation was not restored and subsequently by additional epinephrine if needed...
July 3, 2008: New England Journal of Medicine