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By Roberto Garay-Cabada Pediatrics , Fellow in pediatric Pulmonology
Rebecca F Slykerman, John Thompson, Karen E Waldie, Rinki Murphy, Clare Wall, Edwin A Mitchell
AIM: There may be a link between disruption to the gut microbiota in early life and later neurocognitive outcomes. We hypothesised that antibiotic use in early life is associated with a detrimental effect on later neurocognitive outcomes. METHODS: Eight hundred and seventy-one European mothers and their children enrolled in the Auckland Birthweight Collaborative Study at birth. Information on antibiotic use during the first year of life and between 12 months and three-and-a-half years of age was gathered via maternal interview...
January 2017: Acta Paediatrica
G G Einarsson, D M Comer, L McIlreavey, J Parkhill, M Ennis, M M Tunney, J S Elborn
RATIONALE: The role bacteria play in the progression of COPD has increasingly been highlighted in recent years. However, the microbial community complexity in the lower airways of patients with COPD is poorly characterised. OBJECTIVES: To compare the lower airway microbiota in patients with COPD, smokers and non-smokers. METHODS: Bronchial wash samples from adults with COPD (n=18), smokers with no airways disease (n=8) and healthy individuals (n=11) were analysed by extended-culture and culture-independent Illumina MiSeq sequencing...
September 2016: Thorax
Kotryna Simonyte Sjödin, Linda Vidman, Patrik Rydén, Christina E West
PURPOSE OF REVIEW: The purpose is to review recent studies examining the role of gut microbiota in allergic diseases and asthma. RECENT FINDINGS: Work in experimental models gives further evidence that a disturbed gut microbiota influences the propensity to develop allergic manifestations, and that changing the gut microbiota by dietary means (high fiber/acetate or prebiotics) in pregnancy may reduce the risk of allergic airways disease and food allergy in the offspring, respectively...
August 2016: Current Opinion in Allergy and Clinical Immunology
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