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Novel Addiction Treatments

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12 papers 25 to 100 followers Research to practice potentials across all classes of SoU's. Manipulation of reward and anti-reward via pharmaceuticals, naturopathy, mind-body medicine, and psychotherapy/psychosocial interventions. Criteria must be based in scientific knowledge - example \"Homeopathy\" will be excluded because literally no science backs its claims in any way/yet Hypnosis is included due to significant practice, anecdotal evidence, and several possible reasons for clinical successes even though science is often conflicting.
By Christopher Cook Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's, 60000 beds referral base
https://www.readbyqxmd.com/read/27603752/oxytocin-for-the-treatment-of-drug-and-alcohol-use-disorders
#1
Mary R Lee, Elise M Weerts
There is growing interest in the use of oxytocin (OT) as a potential treatment for alcohol and other substance-use disorders. OT is a neuropeptide that modulates adaptive processes associated with addiction including reward, tolerance, associative learning, memory, and stress responses. OT exerts its effects through interactions with the hypothalamic-pituitary-adrenal axis and multiple neurotransmitter systems including the dopamine mesolimbic reward and corticotrophin-releasing factor stress systems. The effects of OT on stress systems are of high interest, given the strong link between stress, drug use and relapse, and known dysregulation of hypothalamic-pituitary-adrenal-axis activity associated with substance-use disorders...
December 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28485408/genetic-and-pharmacological-antagonism-of-nk1-receptor-prevents-opiate-abuse-potential
#2
A J Sandweiss, M I McIntosh, A Moutal, R Davidson-Knapp, J Hu, A K Giri, T Yamamoto, V J Hruby, R Khanna, T M Largent-Milnes, T W Vanderah
Development of an efficacious, non-addicting analgesic has been challenging. Discovery of novel mechanisms underlying addiction may present a solution. Here we target the neurokinin system, which is involved in both pain and addiction. Morphine exerts its rewarding actions, at least in part, by inhibiting GABAergic input onto substance P (SP) neurons in the ventral tegmental area (VTA), subsequently increasing SP release onto dopaminergic neurons. Genome editing of the neurokinin 1 receptor (NK1R) in the VTA renders morphine non-rewarding...
May 9, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28555075/acute-ketamine-administration-corrects-abnormal-inflammatory-bone-markers-in-major-depressive-disorder
#3
B Kadriu, P W Gold, D A Luckenbaugh, M S Lener, E D Ballard, M J Niciu, I D Henter, L T Park, R T De Sousa, P Yuan, R Machado-Vieira, C A Zarate
Patients with major depressive disorder (MDD) have clinically relevant, significant decreases in bone mineral density (BMD). We sought to determine if predictive markers of bone inflammation-the osteoprotegerin (OPG)-RANK-RANKL system or osteopontin (OPN)-play a role in the bone abnormalities associated with MDD and, if so, whether ketamine treatment corrected the abnormalities. The OPG-RANK-RANKL system plays the principal role in determining the balance between bone resorption and bone formation. RANKL is the osteoclast differentiating factor and diminishes BMD...
May 30, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/21320758/low-doses-of-dextromethorphan-attenuate-morphine-induced-rewarding-via-the-sigma-1-receptor-at-ventral-tegmental-area-in-rats
#4
Shiou-Lan Chen, Kuei-Ying Hsu, Eagle Yi-Kung Huang, Ru-Band Lu, Pao-Luh Tao
Chronic use of morphine causes rewarding and behavioral sensitization, which may lead to the development of psychological craving. In our previous study, we found that a widely used antitussive dextromethorphan (known as a low affinity NMDA receptor antagonist), at doses of 10-20 mg/kg (i.p.), effectively decreased morphine rewarding in rats. In this study, we further investigated the effects and mechanisms of low doses of DM (μg/kg range) on morphine rewarding and behavioral sensitization. A conditioned place preference test was used to determine the rewarding and a locomotor activity test was used to determine the behavioral sensitization induced by the drug(s) in rats...
September 1, 2011: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27862692/ppar%C3%AE-agonism-attenuates-cocaine-cue-reactivity
#5
William R Miller, Robert G Fox, Sonja J Stutz, Scott D Lane, Larry Denner, Kathryn A Cunningham, Kelly T Dineley
Cocaine use disorder is a chronic relapsing condition characterized by compulsive drug seeking and taking even after prolonged abstinence periods. Subsequent exposure to drug-associated cues can promote intense craving and lead to relapse in abstinent humans and rodent models. The responsiveness to these cocaine-related cues, or 'cue reactivity', can trigger relapse and cocaine-seeking behaviors; cue reactivity is measurable in cocaine-dependent humans as well as rodent models. Cue reactivity is thought to be predictive of cocaine craving and relapse...
November 11, 2016: Addiction Biology
https://www.readbyqxmd.com/read/28150390/gray-matter-relationships-to-diagnostic-and-transdiagnostic-features-of-drug-and-behavioral-addictions
#6
Sarah W Yip, Patrick D Worhunsky, Jiansong Xu, Kristen P Morie, R Todd Constable, Robert T Malison, Kathleen M Carroll, Marc N Potenza
Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combines categorical (diagnosis-based) and dimensional (transdiagnostic) approaches to identify neural structural alterations linked to addiction subtypes and trait impulsivity, respectively, across individuals with gambling disorder (n = 35), individuals with cocaine-use disorder (n = 37) and healthy comparison individuals (n = 37)...
February 1, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28557352/effect-of-n-acetylcysteine-on-motivation-seeking-and-relapse-to-ethanol-self-administration
#7
Sophie Lebourgeois, María Carmen González-Marín, Jerome Jeanblanc, Mickael Naassila, Catherine Vilpoux
We report here N-acetylcysteine (NAC) efficacy to reduce operant ethanol self-administration in rats during short-time session of 15 minutes. NAC also reduces seeking and reacquisition following protracted abstinence. Our results suggest for the first time that NAC is a potential new anticraving treatment for reduction of alcohol relapse.
May 30, 2017: Addiction Biology
https://www.readbyqxmd.com/read/27998326/reward-related-neural-activity-and-structure-predict-future-substance-use-in-dysregulated-youth
#8
M A Bertocci, G Bebko, A Versace, S Iyengar, L Bonar, E E Forbes, J R C Almeida, S B Perlman, C Schirda, M J Travis, M K Gill, V A Diwadkar, J L Sunshine, S K Holland, R A Kowatch, B Birmaher, D A Axelson, T W Frazier, L E Arnold, M A Fristad, E A Youngstrom, S M Horwitz, R L Findling, M L Phillips
BACKGROUND: Identifying youth who may engage in future substance use could facilitate early identification of substance use disorder vulnerability. We aimed to identify biomarkers that predicted future substance use in psychiatrically un-well youth. METHOD: LASSO regression for variable selection was used to predict substance use 24.3 months after neuroimaging assessment in 73 behaviorally and emotionally dysregulated youth aged 13.9 (s.d. = 2.0) years, 30 female, from three clinical sites in the Longitudinal Assessment of Manic Symptoms (LAMS) study...
June 2017: Psychological Medicine
https://www.readbyqxmd.com/read/26987308/granger-causality-reveals-a-dominant-role-of-memory-circuit-in-chronic-opioid-dependence
#9
Yi Zhang, Qiang Li, Xiaotong Wen, Weiwei Cai, Guanya Li, Jie Tian, Yi Edi Zhang, Jixin Liu, Kai Yuan, Jizheng Zhao, Wei Wang, Zhenyu Zhou, Mingzhou Ding, Mark S Gold, Yijun Liu, Gene-Jack Wang
Resting-state magnetic resonance imaging has uncovered abnormal functional connectivity in heroin-dependent individuals (HDIs). However, it remains unclear how brain regions implicated in addictions are related in baseline state without conditioned cues in heroin dependent individuals during opioid maintenance treatment (HDIs-OMT). Previous connectivity analysis assessed the strength of correlated activity between brain regions but lacked the ability to infer directional neural interactions. In the current study, we employed Granger causality analysis to investigate directional causal influences among the brain circuits in HDIs-OMT and non-opioid users...
March 14, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27001273/kappa-opioid-receptor-antagonism-and-chronic-antidepressant-treatment-have-beneficial-activities-on-social-interactions-and-grooming-deficits-during-heroin-abstinence
#10
L Lalanne, G Ayranci, D Filliol, C Gavériaux-Ruff, K Befort, B L Kieffer, P-E Lutz
Addiction is a chronic brain disorder that progressively invades all aspects of personal life. Accordingly, addiction to opiates severely impairs interpersonal relationships, and the resulting social isolation strongly contributes to the severity and chronicity of the disease. Uncovering new therapeutic strategies that address this aspect of addiction is therefore of great clinical relevance. We recently established a mouse model of heroin addiction in which, following chronic heroin exposure, 'abstinent' mice progressively develop a strong and long-lasting social avoidance phenotype...
March 22, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27193165/a-partial-trace-amine-associated-receptor-1-agonist-exhibits-properties-consistent-with-a-methamphetamine-substitution-treatment
#11
Yue Pei, Aman Asif-Malik, Marius Hoener, Juan J Canales
Recent evidence suggests that the trace amine-associated receptor 1 (TAAR1) plays a pivotal role in the regulation of dopamine (DA) transmission and psychostimulant action. Several selective TAAR1 agonists have previously shown efficacy in models of cocaine addiction. However, the effects of TAAR1 activation on methamphetamine (METH)-induced behaviours are less well understood, as indeed are the underlying neurochemical mechanisms mediating potential interactions between TAAR1 and METH. Here, in a progressive ratio schedule of reinforcement the partial TAAR1 agonist, RO5263397, reduced the break-point for METH self-administration, while significantly increasing responding maintained by food reward...
May 19, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27212105/dopamine-d4-receptor-stimulation-prevents-nigrostriatal-dopamine-pathway-activation-by-morphine-relevance-for-drug-addiction
#12
Alicia Rivera, Belén Gago, Diana Suárez-Boomgaard, Takashi Yoshitake, Ruth Roales-Buján, Alejandra Valderrama-Carvajal, Ainhoa Bilbao, José Medina-Luque, Zaida Díaz-Cabiale, Kathleen Van Craenenbroeck, Dasiel O Borroto-Escuela, Jan Kehr, Fernando Rodríguez de Fonseca, Luis Santín, Adelaida de la Calle, Kjell Fuxe
Morphine is one of the most effective drugs used for pain management, but it is also highly addictive. Morphine elicits acute and long-term adaptive changes at cellular and molecular level in the brain, which play a critical role in the development of tolerance, dependence and addiction. Previous studies indicated that the dopamine D4 receptor (D4 R) activation counteracts morphine-induced adaptive changes of the μ opioid receptor (MOR) signaling in the striosomes of the caudate putamen (CPu), as well as the induction of several Fos family transcription factors...
May 22, 2016: Addiction Biology
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