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Novel Addiction Treatments

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4 papers 25 to 100 followers Research to practice potentials across all classes of SoU's. Manipulation of reward and anti-reward via pharmaceuticals, naturopathy, mind-body medicine, and psychotherapy/psychosocial interventions. Criteria must be based in scientific knowledge - example \"Homeopathy\" will be excluded because literally no science backs its claims in any way/yet Hypnosis is included due to significant practice, anecdotal evidence, and several possible reasons for clinical successes even though science is often conflicting.
By Christopher Cook Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's, 60000 beds referral base
https://www.readbyqxmd.com/read/26987308/granger-causality-reveals-a-dominant-role-of-memory-circuit-in-chronic-opioid-dependence
#1
Yi Zhang, Qiang Li, Xiaotong Wen, Weiwei Cai, Guanya Li, Jie Tian, Yi Edi Zhang, Jixin Liu, Kai Yuan, Jizheng Zhao, Wei Wang, Zhenyu Zhou, Mingzhou Ding, Mark S Gold, Yijun Liu, Gene-Jack Wang
Resting-state magnetic resonance imaging has uncovered abnormal functional connectivity in heroin-dependent individuals (HDIs). However, it remains unclear how brain regions implicated in addictions are related in baseline state without conditioned cues in heroin dependent individuals during opioid maintenance treatment (HDIs-OMT). Previous connectivity analysis assessed the strength of correlated activity between brain regions but lacked the ability to infer directional neural interactions. In the current study, we employed Granger causality analysis to investigate directional causal influences among the brain circuits in HDIs-OMT and non-opioid users...
March 14, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27001273/kappa-opioid-receptor-antagonism-and-chronic-antidepressant-treatment-have-beneficial-activities-on-social-interactions-and-grooming-deficits-during-heroin-abstinence
#2
L Lalanne, G Ayranci, D Filliol, C Gavériaux-Ruff, K Befort, B L Kieffer, P-E Lutz
Addiction is a chronic brain disorder that progressively invades all aspects of personal life. Accordingly, addiction to opiates severely impairs interpersonal relationships, and the resulting social isolation strongly contributes to the severity and chronicity of the disease. Uncovering new therapeutic strategies that address this aspect of addiction is therefore of great clinical relevance. We recently established a mouse model of heroin addiction in which, following chronic heroin exposure, 'abstinent' mice progressively develop a strong and long-lasting social avoidance phenotype...
March 22, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27193165/a-partial-trace-amine-associated-receptor-1-agonist-exhibits-properties-consistent-with-a-methamphetamine-substitution-treatment
#3
Yue Pei, Aman Asif-Malik, Marius Hoener, Juan J Canales
Recent evidence suggests that the trace amine-associated receptor 1 (TAAR1) plays a pivotal role in the regulation of dopamine (DA) transmission and psychostimulant action. Several selective TAAR1 agonists have previously shown efficacy in models of cocaine addiction. However, the effects of TAAR1 activation on methamphetamine (METH)-induced behaviours are less well understood, as indeed are the underlying neurochemical mechanisms mediating potential interactions between TAAR1 and METH. Here, in a progressive ratio schedule of reinforcement the partial TAAR1 agonist, RO5263397, reduced the break-point for METH self-administration, while significantly increasing responding maintained by food reward...
May 19, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27212105/dopamine-d4-receptor-stimulation-prevents-nigrostriatal-dopamine-pathway-activation-by-morphine-relevance-for-drug-addiction
#4
Alicia Rivera, Belén Gago, Diana Suárez-Boomgaard, Takashi Yoshitake, Ruth Roales-Buján, Alejandra Valderrama-Carvajal, Ainhoa Bilbao, José Medina-Luque, Zaida Díaz-Cabiale, Kathleen Van Craenenbroeck, Dasiel O Borroto-Escuela, Jan Kehr, Fernando Rodríguez de Fonseca, Luis Santín, Adelaida de la Calle, Kjell Fuxe
Morphine is one of the most effective drugs used for pain management, but it is also highly addictive. Morphine elicits acute and long-term adaptive changes at cellular and molecular level in the brain, which play a critical role in the development of tolerance, dependence and addiction. Previous studies indicated that the dopamine D4 receptor (D4 R) activation counteracts morphine-induced adaptive changes of the μ opioid receptor (MOR) signaling in the striosomes of the caudate putamen (CPu), as well as the induction of several Fos family transcription factors...
May 22, 2016: Addiction Biology
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