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Neuroscience

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3 papers 0 to 25 followers
By Rami Kaminski MD Founder and medical director TIIPS
https://www.readbyqxmd.com/read/25651064/identification-of-a-common-neurobiological-substrate-for-mental-illness
#1
Madeleine Goodkind, Simon B Eickhoff, Desmond J Oathes, Ying Jiang, Andrew Chang, Laura B Jones-Hagata, Brissa N Ortega, Yevgeniya V Zaiko, Erika L Roach, Mayuresh S Korgaonkar, Stuart M Grieve, Isaac Galatzer-Levy, Peter T Fox, Amit Etkin
IMPORTANCE: Psychiatric diagnoses are currently distinguished based on sets of specific symptoms. However, genetic and clinical analyses find similarities across a wide variety of diagnoses, suggesting that a common neurobiological substrate may exist across mental illness. OBJECTIVE: To conduct a meta-analysis of structural neuroimaging studies across multiple psychiatric diagnoses, followed by parallel analyses of 3 large-scale healthy participant data sets to help interpret structural findings in the meta-analysis...
April 2015: JAMA Psychiatry
https://www.readbyqxmd.com/read/25491076/clinical-and-experimental-studies-of-potentially-pathogenic-brain-directed-autoantibodies-current-knowledge-and-future-directions
#2
REVIEW
James Varley, Angela Vincent, Sarosh R Irani
The field of neuronal surface-directed antibody-mediated diseases of the central nervous system has dramatically expanded in the last few years and now forms an important cluster of treatable neurological conditions. In this review, we focus on three areas. First, we review the demographics, clinical features and treatment responses of these conditions. Second, we consider their pathophysiology and compare autoantibody mechanisms and their effects to genetic or pharmacological disruptions of the target antigens...
2015: Journal of Neurology
https://www.readbyqxmd.com/read/16456083/a-cortical-region-consisting-entirely-of-face-selective-cells
#3
Doris Y Tsao, Winrich A Freiwald, Roger B H Tootell, Margaret S Livingstone
Face perception is a skill crucial to primates. In both humans and macaque monkeys, functional magnetic resonance imaging (fMRI) reveals a system of cortical regions that show increased blood flow when the subject views images of faces, compared with images of objects. However, the stimulus selectivity of single neurons within these fMRI-identified regions has not been studied. We used fMRI to identify and target the largest face-selective region in two macaques for single-unit recording. Almost all (97%) of the visually responsive neurons in this region were strongly face selective, indicating that a dedicated cortical area exists to support face processing in the macaque...
February 3, 2006: Science
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