Andrew H Kemp, Renerio Fráguas, Andre R Brunoni, Marcio S Bittencourt, Maria A Nunes, Eduardo M Dantas, Rodrigo V Andreão, José G Mill, Antonio L P Ribeiro, Julian Koenig, Julian F Thayer, Isabela M Benseñor, Paulo A Lotufo
OBJECTIVE: Debate has focused on the effects of the selective serotonin reuptake inhibitor (SSRI) antidepressants on heart rate (HR) and HR variability (HRV), both of which are predictors of adverse cardiovascular events. Here, we examine the associations between specific SSRI antidepressants and resting state HR (and HRV) after accounting for a host of potential confounding factors using propensity score techniques. METHODS: Participants included 10,466 not taking antidepressants, 46 participants taking escitalopram, 86 taking citalopram, 66 taking fluoxetine, 103 taking paroxetine, and 139 taking sertraline...
September 2016: Psychosomatic Medicine