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Alain Saraux, Jacques-Olivier Pers, Valérie Devauchelle-Pensec
Primary Sjögren syndrome (pSS) is a progressive autoimmune disease characterized by sicca and systemic manifestations. In this Review, we summarize the available data on topical and systemic medications, according to clinical signs and disease activity, and we describe the ongoing studies using biologic drugs in the treatment of pSS. Expanding knowledge about the epidemiology, classification criteria, systemic activity scoring (ESSDAI) and patient-reported outcomes (ESSPRI) is driving active research. Treatment decisions are based on the evaluation of symptoms and extraglandular manifestations...
August 2016: Nature Reviews. Rheumatology
Steven E Carsons, Frederick B Vivino, Ann Parke, Nancy Carteron, Vidya Sankar, Richard Brasington, Michael T Brennan, William Ehlers, Robert Fox, Hal Scofield, Katherine M Hammitt, Julius Birnbaum, Stuart Kassan, Steven Mandel
OBJECTIVE: The Sjögren's Syndrome Foundation clinical practice guidelines (CPGs) are designed to improve quality and consistency of care in Sjögren's syndrome by offering recommendations for management. METHODS: Management questions for the systemic manifestations of Sjögren's syndrome were posed by the CPG committee with input from patients and rheumatologists. Clinical questions were assigned to a topic review group that performed systematic reviews and data extraction and drafted guidelines...
April 2017: Arthritis Care & Research
Jean Kim, Daniel Sun, Rebecca Ozl, Thomas Grader-Beck, Julius Birnbaum, Esen K Akpek, Alan N Baer
OBJECTIVES/HYPOTHESIS: To validate a technique and outcomes of labial minor salivary gland biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). STUDY DESIGN: Prospective cohort study. METHODS: Clinical data were prospectively obtained pre- and postbiopsy using patient-reported questionnaires. LSGB was performed using described methods. Specimens were analyzed by a pathologist with expertise in SS and assessed using established criteria to determine the focus score...
September 2016: Laryngoscope
Francesco Ferro, Roberta Vagelli, Cosimo Bruni, Giacomo Cafaro, Elisa Marcucci, Elena Bartoloni, Chiara Baldini
Sjögren's syndrome (SS) is a complex heterogeneous disease charactered by a broad spectrum of clinical and serological manifestations, including non-Hodgkin's lymphoma (NHL). Last year, 2015, was an exciting year for research into SS with novel insights into disease pathogenesis, clinical aspects and long-term outcomes. In addition, the use of biologic therapy in SS is rapidly expanding, with new evidence emerging regarding potential therapeutic targets. In this article, we will provide an overview of the recent literature on the pathogenesis, clinical features and novel treatments of SS...
March 2016: Clinical and Experimental Rheumatology
Roberta Priori, Antonina Minniti, Barbara Antonazzo, Massimo Fusconi, Guido Valesini, Giuseppe Curcio
OBJECTIVES: To assess the sleep quality in primary Sjögren's syndrome (pSS) patients and evaluate its relationship with the disease, quality of life and mood disorders. METHODS: The sleep quality of 29 pSS women and 29 matched controls was assessed by the Pittsburgh Sleep Quality Index (PSQI). Seven domains are grouped according to three factors: F1 perceived sleep quality (subjective sleep quality, sleep latency, use of sleeping medication), F2 sleep efficiency (sleep duration, habitual sleep efficiency) and F3 daily disturbances (sleep disturbances, daytime dysfunction)...
May 2016: Clinical and Experimental Rheumatology
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