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https://www.readbyqxmd.com/read/28153111/mode-of-death-in-heart-failure-with-preserved-ejection-fraction
#1
REVIEW
Muthiah Vaduganathan, Ravi B Patel, Alexander Michel, Sanjiv J Shah, Michele Senni, Mihai Gheorghiade, Javed Butler
Little is known about specific modes of death in patients with heart failure with preserved ejection fraction (HFpEF). Herein, the authors critically appraise the current state of data and offer potential future directions. They conducted a systematic review of 1,608 published HFpEF papers from January 1, 1985, to December 31, 2015, which yielded 8 randomized clinical trials and 24 epidemiological studies with mode-of-death data. Noncardiovascular modes of death represent an important competing risk in HFpEF...
February 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28137981/sudden-cardiac-death-the-pro-arrhythmic-interaction-of-an-acute-loading-with-an-underlying-substrate
#2
George R Sutherland
Sudden cardiac death (SCD) is a complex phenomenon, occurring either in apparently normal individuals or in those where there is a recognized underlying cardiac abnormality. In both groups, the lethal arrhythmia has frequently been related to the physiologic trigger of either exercise or stress. Prior research into SCD has focused mainly on a combination of identifying either vulnerable myocardial substrates; pharmacological approaches to altering electrical activation/repolarisation in substrates; or the suppression of induced lethal arrhythmias with implantable defibrillators...
January 29, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28063810/2017-acc-expert-consensus-decision-pathway-for-transcatheter-aortic-valve-replacement-in-the-management-of-adults-with-aortic-stenosis-a-report-of-the-american-college-of-cardiology-task-force-on-clinical-expert-consensus-documents
#3
Catherine M Otto, Dharam J Kumbhani, Karen P Alexander, John H Calhoon, Milind Y Desai, Sanjay Kaul, James C Lee, Carlos E Ruiz, Christina M Vassileva
No abstract text is available yet for this article.
December 21, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27990270/recent-advances-in-the-management-of-pulmonary-arterial-hypertension
#4
REVIEW
Halley Tsai, Yon K Sung, Vinicio de Jesus Perez
Over the past 20 years, there has been an explosion in the development of therapeutics to treat pulmonary arterial hypertension (PAH), a rare but life-threatening disorder associated with progressive elevation of pulmonary pressures and severe right heart failure. Recently, the field has seen the introduction of riociguat, a soluble guanylate cyclase stimulator, a new endothelin receptor antagonist (macitentan), and oral prostanoids (treprostinil and selexipag). Besides new drugs, there have been significant advances in defining the role of upfront combination therapy in treatment-naïve patients as well as proposed methods to deliver systemic prostanoids by use of implantable pumps...
2016: F1000Research
https://www.readbyqxmd.com/read/28012615/acc-aats-aha-ase-asnc-scai-scct-sts-2016-appropriate-use-criteria-for-coronary-revascularization-in-patients-with-acute-coronary-syndromes-a-report-of-the-american-college-of-cardiology-appropriate-use-criteria-task-force-american-association-for-thoracic-surgery
#5
https://www.readbyqxmd.com/read/28011759/-end-stage-heart-failure-therapy-potential-lessons-from-congenital-heart-disease-from-pulmonary-artery-banding-and-interatrial-communication-to-parallel-circulation
#6
REVIEW
Dietmar Schranz, Hakan Akintuerk, Norbert F Voelkel
The final therapy of 'end-stage heart failure' is orthotopic heart, lung or heart-lung transplantation. However, these options are not available for many patients worldwide. Therefore, novel therapeutical strategies are needed. Based on pathophysiological insights regarding (1) the long-term impact of an obstructive pulmonary outflow tract in neonates with congenitally corrected transposition of the great arteries, (2) the importance of a restrictive versus a non-restrictive atrial septum in neonates born with a borderline left ventricle and (3) the significance of both, a patent foramen ovale and/or open ductus arteriosus for survival of newborns with persistent pulmonary hypertension, the current review introduces some therapeutical strategies that may be applicable to selected patients with heart failure...
February 15, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27942729/why-oxygen-is-not-necessary-for-all-stemis
#7
Nick Fitterman
No abstract text is available yet for this article.
February 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27895025/medical-treatment-of-aortic-stenosis
#8
Guillaume Marquis-Gravel, Björn Redfors, Martin B Leon, Philippe Généreux
Untreated, severe, symptomatic aortic stenosis is associated with a dismal prognosis. The only treatment shown to improve survival is aortic valve replacement; however, before symptoms occur, aortic stenosis is preceded by a silent, latent phase characterized by a slow progression at the molecular, cellular, and tissue levels. In theory, specific medical therapy should halt aortic stenosis progression, reduce its hemodynamic repercussions on left ventricular function and remodeling, and improve clinical outcomes...
November 29, 2016: Circulation
https://www.readbyqxmd.com/read/27881554/o-pioneers-the-beginning-of-the-end-of-full-dose-triple-therapy-with-warfarin
#9
EDITORIAL
Deepak L Bhatt
No abstract text is available yet for this article.
January 24, 2017: Circulation
https://www.readbyqxmd.com/read/27884252/differentiation-of-constriction-and-restriction-complex-cardiovascular-hemodynamics
#10
REVIEW
Jeffrey B Geske, Nandan S Anavekar, Rick A Nishimura, Jae K Oh, Bernard J Gersh
Differentiation of constrictive pericarditis (CP) from restrictive cardiomyopathy (RCM) is a complex and often challenging process. Because CP is a potentially curable cause of heart failure and therapeutic options for RCM are limited, distinction of these 2 conditions is critical. Although different in regard to etiology, prognosis, and treatment, CP and RCM share a common clinical presentation of predominantly right-sided heart failure, in the absence of significant left ventricular systolic dysfunction or valve disease, due to impaired ventricular diastolic filling...
November 29, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27884254/troponin-testing-for-clinicians
#11
REVIEW
John E Brush, Sanjay Kaul, Harlan M Krumholz
The analytical performance of troponin assays has improved markedly in the last 2 decades. The variety of assays, their evolution over time, and their critical importance in influencing care, mandates the need for skills in their use. There are 3 critical elements necessary for optimal use of troponin testing in clinical care, as follows: 1) the analytical performance of the assay; 2) the clinical sensitivity and specificity of the test result; and 3) the clinical reasoning for ordering and the proper clinical context for interpreting the test result...
November 29, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27571011/defibrillator-implantation-in-patients-with-nonischemic-systolic-heart-failure
#12
RANDOMIZED CONTROLLED TRIAL
Lars Køber, Jens J Thune, Jens C Nielsen, Jens Haarbo, Lars Videbæk, Eva Korup, Gunnar Jensen, Per Hildebrandt, Flemming H Steffensen, Niels E Bruun, Hans Eiskjær, Axel Brandes, Anna M Thøgersen, Finn Gustafsson, Kenneth Egstrup, Regitze Videbæk, Christian Hassager, Jesper H Svendsen, Dan E Høfsten, Christian Torp-Pedersen, Steen Pehrson
Background The benefit of an implantable cardioverter-defibrillator (ICD) in patients with symptomatic systolic heart failure caused by coronary artery disease has been well documented. However, the evidence for a benefit of prophylactic ICDs in patients with systolic heart failure that is not due to coronary artery disease has been based primarily on subgroup analyses. The management of heart failure has improved since the landmark ICD trials, and many patients now receive cardiac resynchronization therapy (CRT)...
September 29, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27832612/current-diagnostic-and-treatment-strategies-for-specific-dilated-cardiomyopathies-a-scientific-statement-from-the-american-heart-association
#13
Biykem Bozkurt, Monica Colvin, Jennifer Cook, Leslie T Cooper, Anita Deswal, Gregg C Fonarow, Gary S Francis, Daniel Lenihan, Eldrin F Lewis, Dennis M McNamara, Elfriede Pahl, Ramachandran S Vasan, Kumudha Ramasubbu, Kismet Rasmusson, Jeffrey A Towbin, Clyde Yancy
No abstract text is available yet for this article.
December 6, 2016: Circulation
https://www.readbyqxmd.com/read/27836915/cardiac-diagnostic-work-up-of-ischaemic-stroke
#14
REVIEW
Hayang Yang, Martina Nassif, Paul Khairy, Joris R de Groot, Yvo B W E M Roos, Robbert J de Winter, Barbara J M Mulder, Berto J Bouma
Cardioembolic sources account for 20-30% of ischaemic strokes and are important to identify considering their prognostic and therapeutic implications. During the past years, new developments have been made in the cardiac diagnostic evaluation and management of patients with ischaemic stroke, especially regarding strokes of unknown aetiology. These recent advances have had a major impact on our understanding of embolic strokes, their diagnostic work-up, and clinical management. Herein, we propose a cardiac diagnostic work-up scheme for patients with ischaemic stroke from definite cardioembolic sources and embolic strokes of undetermined source...
November 10, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27771985/five-year-outcomes-after-off-pump-or-on-pump-coronary-artery-bypass-grafting
#15
RANDOMIZED CONTROLLED TRIAL
André Lamy, P J Devereaux, Dorairaj Prabhakaran, David P Taggart, Shengshou Hu, Zbynek Straka, Leopoldo S Piegas, Alvaro Avezum, Ahmet R Akar, Fernando Lanas Zanetti, Anil R Jain, Nicolas Noiseux, Chandrasekar Padmanabhan, Juan-Carlos Bahamondes, Richard J Novick, Liang Tao, Pablo A Olavegogeascoechea, Balram Airan, Toomas-Andres Sulling, Richard P Whitlock, Yongning Ou, Peggy Gao, Shirley Pettit, Salim Yusuf
Background We previously reported that there was no significant difference at 30 days or at 1 year in the rate of the composite outcome of death, stroke, myocardial infarction, or renal failure between patients who underwent coronary-artery bypass grafting (CABG) performed with a beating-heart technique (off-pump) and those who underwent CABG performed with cardiopulmonary bypass (on-pump). We now report the results at 5 years (the end of the trial). Methods A total of 4752 patients (from 19 countries) who had coronary artery disease were randomly assigned to undergo off-pump or on-pump CABG...
15, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27789570/management-of-antithrombotic-therapy-after-bleeding-in-patients-with-coronary-artery-disease-and-or-atrial-fibrillation-expert-consensus-paper-of-the-european-society-of-cardiology-working-group-on-thrombosis
#16
Sigrun Halvorsen, Robert F Storey, Bianca Rocca, Dirk Sibbing, Jurrien Ten Berg, Erik Lerkevang Grove, Thomas W Weiss, Jean-Philippe Collet, Felicita Andreotti, Dietrich C Gulba, Gregory Y H Lip, Steen Husted, Gemma Vilahur, Joao Morais, Freek W A Verheugt, Angel Lanas, Rustam Al-Shahi Salman, Philippe Gabriel Steg, Kurt Huber
No abstract text is available yet for this article.
October 27, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27737747/anticoagulation-during-pregnancy-evolving-strategies-with-a-focus-on-mechanical-valves
#17
REVIEW
Laith Alshawabkeh, Katherine E Economy, Anne Marie Valente
Pregnancy is associated with a hypercoagulable state. Women requiring anticoagulation need careful attention throughout pregnancy and the post-partum period. The choice of anticoagulant therapy, the degree of monitoring, and the therapeutic target should be modulated by balancing the risks and the benefits to the mother and fetus. Many of the available anticoagulant agents may be used safely in pregnancy, but they are disadvantaged by competing efficacy and risks to the mother and fetus. For example, vitamin K antagonists are the most efficacious for preventing mechanical valve thrombosis, but they pose risks to the fetus...
October 18, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27734560/right-ventricular-dysfunction-and-pulmonary-hypertension-in-heart-failure-with-preserved-ejection-fraction
#18
EDITORIAL
Masaru Obokata, Barry A Borlaug
No abstract text is available yet for this article.
December 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27734699/-thyroid-hormones-and-cardiovascular-system
#19
Zdeňka Límanová, Jan Jiskra
Cardiovascular system is essentially affected by thyroid hormones by way of their genomic and non-genomic effects. Untreated overt thyroid dysfunction is associated with higher cardiovascular risk. Although it has been studied more than 3 decades, in subclinical thyroid dysfunction the negative effect on cardiovascular system is much more controversial. Large meta-analyses within last 10 years have shown that subclinical hyperthyroidism is associated with higher cardiovascular risk than subclinical hypothyroidism...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27729421/aspirin-for-primary-cardiovascular-risk-prevention-and-beyond-in-diabetes-mellitus
#20
Davide Capodanno, Dominick J Angiolillo
Daily administration of low-dose aspirin has proved to be beneficial in preventing recurrent cardiovascular events. However, the role of aspirin for primary prevention in patients with no overt cardiovascular disease is more controversial. In fact, in lower risk patients, the modest benefit in reducing serious vascular events can be offset by the increased risk of bleeding, including intracranial and gastrointestinal hemorrhage. Diabetes mellitus has been associated with a substantially increased risk of both first and recurrent atherothrombotic events, which makes aspirin therapy of potential value in these subjects...
November 15, 2016: Circulation
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