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JC 2016

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2 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27178479/platelet-transfusion-versus-standard-care-after-acute-stroke-due-to-spontaneous-cerebral-haemorrhage-associated-with-antiplatelet-therapy-patch-a-randomised-open-label-phase-3-trial
#1
RANDOMIZED CONTROLLED TRIAL
M Irem Baharoglu, Charlotte Cordonnier, Rustam Al-Shahi Salman, Koen de Gans, Maria M Koopman, Anneke Brand, Charles B Majoie, Ludo F Beenen, Henk A Marquering, Marinus Vermeulen, Paul J Nederkoorn, Rob J de Haan, Yvo B Roos
BACKGROUND: Platelet transfusion after acute spontaneous primary intracerebral haemorrhage in people taking antiplatelet therapy might reduce death or dependence by reducing the extent of the haemorrhage. We aimed to investigate whether platelet transfusion with standard care, compared with standard care alone, reduced death or dependence after intracerebral haemorrhage associated with antiplatelet therapy use. METHODS: We did this multicentre, open-label, masked-endpoint, randomised trial at 60 hospitals in the Netherlands, UK, and France...
June 25, 2016: Lancet
https://www.readbyqxmd.com/read/27117874/a-randomized-controlled-noninferiority-trial-of-single-dose-of%C3%A2-oral-dexamethasone-versus-5-days-of-oral-prednisone-in-acute%C3%A2-adult-asthma
#2
Matthew W Rehrer, Bella Liu, Marcela Rodriguez, Joseph Lam, Harrison J Alter
STUDY OBJECTIVE: Oral dexamethasone demonstrates bioavailability similar to that of oral prednisone but has a longer half-life. We evaluate whether a single dose of oral dexamethasone plus 4 days of placebo is not inferior to 5 days of oral prednisone in treatment of adults with mild to moderate asthma exacerbations to prevent relapse defined as an unscheduled return visit for additional treatment for persistent or worsening asthma within 14 days. METHODS: Adult emergency department patients (aged 18 to 55 years) were randomized to receive either a single dose of 12 mg of oral dexamethasone with 4 days of placebo or a 5-day course of oral prednisone 60 mg a day...
April 14, 2016: Annals of Emergency Medicine
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