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Neuroradiology CNS tumours

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72 papers 25 to 100 followers Neuroradiology articles related to central nervous system tumours.
By Sebastian Bravo-Grau Neuroradiology Fellow - Radiologist
https://www.readbyqxmd.com/read/27899081/endoscopic-endonasal-pituitary-adenomas-surgery-the-surgical-experience-of-178-consecutive-patients-and-learning-curve-of-two-neurosurgeons
#1
Xuefei Shou, Ming Shen, Qilin Zhang, Yichao Zhang, Wenqiang He, Zengyi Ma, Yao Zhao, Shiqi Li, Yongfei Wang
BACKGROUND: We aim to study surgical technique and analyze the related factors affecting tumor total removal and postoperative endocrinological remission for endoscopic endonasal pituitary adenomas surgery. METHODS: We retrospectively analyzed 178 endoscopic endonasal pituitary adenomas surgery from March 2011 to May 2014. Endonasal approach included the routine transnasal-sphenoidal approach, transnasal- maxillary sinus approach in four cases and transnasal-clivus approach in one case...
November 30, 2016: BMC Neurology
https://www.readbyqxmd.com/read/28255030/a-multiparametric-model-for-mapping-cellularity-in-glioblastoma-using-radiographically-localized-biopsies
#2
P D Chang, H R Malone, S G Bowden, D S Chow, B J A Gill, T H Ung, J Samanamud, Z K Englander, A M Sonabend, S A Sheth, G M McKhann, M B Sisti, L H Schwartz, A Lignelli, J Grinband, J N Bruce, P Canoll
BACKGROUND AND PURPOSE: The complex MR imaging appearance of glioblastoma is a function of underlying histopathologic heterogeneity. A better understanding of these correlations, particularly the influence of infiltrating glioma cells and vasogenic edema on T2 and diffusivity signal in nonenhancing areas, has important implications in the management of these patients. With localized biopsies, the objective of this study was to generate a model capable of predicting cellularity at each voxel within an entire tumor volume as a function of signal intensity, thus providing a means of quantifying tumor infiltration into surrounding brain tissue...
March 2, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28183840/imaging-characteristics-of-pediatric-diffuse-midline-gliomas-with-histone-h3-k27m-mutation
#3
M S Aboian, D A Solomon, E Felton, M C Mabray, J E Villanueva-Meyer, S Mueller, S Cha
BACKGROUND AND PURPOSE: The 2016 World Health Organization Classification of Tumors of the Central Nervous System includes "diffuse midline glioma with histone H3 K27M mutation" as a new diagnostic entity. We describe the MR imaging characteristics of this new tumor entity in pediatric patients. MATERIALS AND METHODS: We retrospectively reviewed imaging features of pediatric patients with midline gliomas with or without the histone H3 K27 mutation. We evaluated the imaging features of these tumors on the basis of location, enhancement pattern, and necrosis...
February 9, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27924360/perfusion-imaging-of-brain-gliomas-using-arterial-spin-labeling-correlation-with-histopathological-vascular-density-in-mri-guided-biopsies
#4
Di Ningning, Pang Haopeng, Dang Xuefei, Cheng Wenna, Ren Yan, Wu Jingsong, Yao Chengjun, Yao Zhenwei, Feng Xiaoyuan
INTRODUCTION: This study was designed to determine if cerebral blood flow (CBF) derived from arterial spin labeling (ASL) perfusion imaging could be used to quantitatively evaluate the microvascular density (MVD) of brain gliomas on a "point-to-point" basis by matching CBF areas and surgical biopsy sites as accurate as possible. METHODS: The study enrolled 47 patients with treatment-naive brain gliomas who underwent preoperative ASL, 3D T1-weighted imaging with gadolinium contrast enhancement (3D T1C+), and T2 fluid acquisition of inversion recovery (T2FLAIR) sequences before stereotactic surgery...
January 2017: Neuroradiology
https://www.readbyqxmd.com/read/28074235/long-term-brain-structural-magnetic-resonance-imaging-and-cognitive-functioning-in-children-treated-for-acute-lymphoblastic-leukemia-with-high-dose-methotrexate-chemotherapy-alone-or-combined-with-cns-radiotherapy-at-reduced-total-dose-to-12%C3%A2-gy
#5
Olga Zając-Spychała, Mikołaj A Pawlak, Katarzyna Karmelita-Katulska, Jakub Pilarczyk, Katarzyna Derwich, Jacek Wachowiak
INTRODUCTION: The aim of this study was to assess the long-term side effects of central nervous system prophylaxis (high-dose chemotherapy alone vs chemotherapy and CNS radiotherapy) according to the ALL IC-BFM 2002. METHODS: Thirty-tree children aged 6.7-19.9 years have been studied. The control group consisted of 12 children newly diagnosed with acute lymphoblastic leukemia. We assessed subcortical gray matter volume using automatic MRI segmentation and cognitive performance to identify differences between two therapeutic schemes and patients prior to treatment...
January 10, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28101641/volumetric-growth-rates-of-meningioma-and-its-correlation-with-histological-diagnosis-and-clinical-outcome-a-systematic-review
#6
REVIEW
Daniel M Fountain, Wai Cheong Soon, Tomasz Matys, Mathew R Guilfoyle, Ramez Kirollos, Thomas Santarius
INTRODUCTION: Tumour growth has been used to successfully predict progression-free survival in low-grade glioma. This systematic review sought to establish the evidence base regarding the correlation of volumetric growth rates with histological diagnosis and potential to predict clinical outcome in patients with meningioma. METHODS: This systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines...
March 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28048511/su-d-207a-02-possible-characterization-of-the-brain-tumor-vascular-environment-by-a-novel-strategy-of-quantitative-analysis-in-dynamic-contrast-enhanced-mr-imaging-a-combination-of-both-patlak-and-logan-analyses
#7
S Yee, P Chinnaiyan, J Wloch, M Pirkola, D Yan
PURPOSE: The majority of quantitative analyses involving dynamic contrast enhanced (DCE) MRI have been performed to obtain kinetic parameters such as Ktrans and ve. Such analyses are generally performed assuming a "reversible" tissue compartment, where the tracer is assumed to be rapidly equilibrated between the plasma and tissue compartments. However, some tumor vascular environments may be more suited for a "non-reversible" tissue compartment, where, as with FDG PET imaging, the tracer is continuously deposited into the tissue compartment (or the return back to the plasma compartment is very slow in the imaging time scale)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27647915/mechanism-of-inhibition-of-the-tumor-suppressor-patched-by-sonic-hedgehog
#8
Hanna Tukachinsky, Kostadin Petrov, Miyako Watanabe, Adrian Salic
The Hedgehog cell-cell signaling pathway is crucial for animal development, and its misregulation is implicated in numerous birth defects and cancers. In unstimulated cells, pathway activity is inhibited by the tumor suppressor membrane protein, Patched. Hedgehog signaling is triggered by the secreted Hedgehog ligand, which binds and inhibits Patched, thus setting in motion the downstream events in signal transduction. Despite its critical importance, the mechanism by which Hedgehog antagonizes Patched has remained unknown...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28084908/a-novel-weighted-scoring-system-for-estimating-the-risk-of-rapid-growth-in-untreated-intracranial-meningiomas
#9
Eun Jung Lee, Jeong Hoon Kim, Eun Suk Park, Young-Hoon Kim, Jae Koo Lee, Seok Ho Hong, Young Hyun Cho, Chang Jin Kim
OBJECTIVE Advances in neuroimaging techniques have led to the increased detection of asymptomatic intracranial meningiomas (IMs). Despite several studies on the natural history of IMs, a comprehensive evaluation method for estimating the growth potential of these tumors, based on the relative weight of each risk factor, has not been developed. The aim of this study was to develop a weighted scoring system that estimates the risk of rapid tumor growth to aid treatment decision making. METHODS The authors performed a retrospective analysis of 232 patients with presumed IM who had been prospectively followed up in the absence of treatment from 1997 to 2013...
January 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28034567/comparison-between-perfusion-computed-tomography-and-dynamic-contrast-enhanced-magnetic-resonance-imaging-in-assessing-glioblastoma-microvasculature
#10
COMPARATIVE STUDY
Zhong Zheng Jia, Wei Shi, Jin Long Shi, Dan Dan Shen, Hong Mei Gu, Xue Jun Zhou
PURPOSE: Perfusion computed tomography (PCT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide independent measurements of biomarkers related to tumor perfusion. The aim of this study was to compare the two techniques in assessing glioblastoma microvasculature. MATERIALS AND METHODS: Twenty-five patients diagnosed with glioblastoma (14 males and 11 females; 51±11years old, ranging from 33 to 70 years) were includede in this prospective study...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28077138/fish-intake-and-the-risk-of-brain-tumor-a-meta-analysis-with-systematic-review
#11
REVIEW
Wei Lian, Renzhi Wang, Bing Xing, Yong Yao
BACKGROUND: Fish, rich in ω-3 polyunsaturated fatty acids, has been found to be associated with lower risk of several types of cancer risk, and beneficial for brain development. However, the association between fish intake and brain tumor risk is still inconsistent. Therefore, we conducted a meta-analysis to clarify the association. METHODS: Relevant studies were identified from PubMed and EMBASE databases. The pooled relative risks were obtained by the fixed-effects model when no substantial heterogeneity was observed...
January 11, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28079713/interrogating-idh-mutation-in-brain-tumor-magnetic-resonance-and-hyperpolarization
#12
Jingzhe Hu, Travis C Salzillo, Napapon Sailasuta, Frederick F Lang, Pratip Bhattacharya
Magnetic resonance spectroscopy (MRS) offers the possibility to noninvasively quantify 2HG concentration in the brain in the clinic, thereby serving as a valuable tool for patient-stratification as well as targeted treatment monitoring. Recently, hyperpolarized magnetic resonance techniques have opened up new opportunities for metabolic imaging not possible with conventional MRS in the brain. With over 10,000-fold increase in signal-to-noise ratio (SNR), dynamic metabolic processes can be interrogated in vivo with very high specificity by hyperpolarized MRI...
February 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28038915/preoperative-grading-of-supratentorial-gliomas-using-high-or-standard-b-value-diffusion-weighted-mr-imaging-at-3t
#13
M M Cihangiroglu, E Ozturk-Isik, Z Firat, O Kilickesmez, A M Ulug, U Ture
PURPOSE: The goal of this study was to compare diffusion-weighted magnetic resonance imaging (DW-MRI) using high b-value (b=3000s/mm(2)) to DW-MRI using standard b-value (b=1000s/mm(2)) in the preoperative grading of supratentorial gliomas. MATERIALS AND METHODS: Fifty-three patients with glioma had brain DW-MRI at 3T using two different b-values (b=1000s/mm(2) and b=3000s/mm(2)). There were 35 men and 18 women with a mean age of 40.5±17.1 years (range: 18-79 years)...
December 27, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28039365/complete-prevalence-of-malignant-primary-brain-tumors-registry-data-in-the-united-states-compared-with-other-common-cancers-2010
#14
Adah S Zhang, Quinn T Ostrom, Carol Kruchko, Lisa Rogers, David M Peereboom, Jill S Barnholtz-Sloan
BACKGROUND: Complete prevalence proportions illustrate the burden of disease in a population. This study estimates the 2010 complete prevalence of malignant primary brain tumors overall and by Central Brain Tumor Registry of the United States (CBTRUS) histology groups, and compares the brain tumor prevalence estimates to the complete prevalence of other common cancers as determined by the Surveillance, Epidemiology, and End Results Program (SEER) by age at prevalence (2010): children (0-14 y), adolescent and young adult (AYA) (15-39 y), and adult (40+ y)...
December 29, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28040713/the-impact-of-body-mass-index-and-height-on-the-risk-for-glioblastoma-and-other-glioma-subgroups-a-large-prospective-cohort-study
#15
Markus K H Wiedmann, Cathrine Brunborg, Antonio Di Ieva, Kristina Lindemann, Tom B Johannesen, Lars Vatten, Eirik Helseth, John A Zwart
BACKGROUND: Glioma comprises a heterogeneous group of mostly malignant brain tumors, whereof glioblastoma (GBM) represents the largest and most lethal subgroup. Body height and body mass index (BMI) are risk factors for other cancers, but no previous study has examined anthropometric data in relation to different glioma subgroups. METHODS: This prospective cohort study includes 1.8 million Norwegian women and men between ages 14 and 80 years at baseline. Body weight and height were measured, and incident cases of glioma were identified by linkage to the National Cancer Registry...
December 31, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27712793/lymphomas-part-2
#16
REVIEW
Lara A Brandão, Mauricio Castillo
There are 2 types of central nervous system lymphoma: primary and secondary. Both have variable imaging features making them diagnostic challenges. Furthermore, a patient's immune status significantly alters the imaging findings. Familiarity with typical appearances, variations, and common mimics aids radiologists in appropriately considering lymphoma in the differential diagnosis. Moreover, special types of lymphoma, such as lymphomatosis cerebri, intravascular lymphoma, and lymphomatoid granulomatosis, also are found...
November 2016: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/27712792/lymphomas-part-1
#17
REVIEW
Lara A Brandão, Mauricio Castillo
Primary central nervous system lymphomas are aggressive, high-cell-density tumors. There is recent increase in their incidence in immunocompetent patients. Knowledge of imaging findings on computed tomography and conventional MR imaging is important to suggest the diagnosis. Moreover, information obtained from advanced MR imaging techniques, such as diffusion-weighted imaging, diffusion tensor imaging, MR spectroscopy, perfusion-weighted imaging, and dynamic contrast-enhanced studies, increases diagnostic confidence and helps distinguish them from other aggressive intracranial tumors...
November 2016: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/27712795/posttreatment-evaluation-of-brain-gliomas
#18
REVIEW
Mark F Dalesandro, Jalal B Andre
The imaging of treated gliomas is complicated by a variety of treatment related effects, which can falsely simulate disease improvement or progression. Distinguishing between disease progression and treatment effects is difficult with standard MR imaging pulse sequences and added specificity can be gained by the addition of advanced imaging techniques.
November 2016: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/27712796/metastasis-in-adult-brain-tumors
#19
REVIEW
Ramon Francisco Barajas, Soonmee Cha
Metastatic cancer to the central nervous system is primarily deposited by hematogenous spread in various anatomically distinct regions: calvarial, pachymeningeal, leptomeningeal, and brain parenchyma. A patient's overall clinical status and the information needed to make treatment decisions are the primary considerations in initial imaging modality selection. Contrast-enhanced MR imaging is the preferred imaging modality. Morphologic MR imaging is limited to delineating anatomic deraignment of tissues. Dynamic susceptibility contrast-enhanced perfusion and diffusion-weighted physiology-based MR imaging sequences have been developed that complement morphologic MR imaging by providing additional diagnostic information...
November 2016: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/27712799/adult-brain-tumors-and-pseudotumors-interesting-bizarre-cases
#20
REVIEW
Lazaro D Causil, Romy Ames, Paulo Puac, Mauricio Castillo
Some brain tumors results are interesting due to their rarity at presentation and overwhelming imaging characteristics, posing a diagnostic challenge in the eyes of any experienced neuroradiologist. This article focuses on the most important features regarding epidemiology, location, clinical presentation, histopathology, and imaging findings of cases considered "bizarre." A review of the most recent literature dealing with these unusual tumors and pseudotumors is presented, highlighting key points related to the diagnosis, treatments, outcomes, and differential diagnosis...
November 2016: Neuroimaging Clinics of North America
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