Joo Ho Lee, Jeong Eun Lee, Jee Ye Kahng, Se Hoon Kim, Jun Sung Park, Seon Jin Yoon, Ji-Yong Um, Woo Kyeong Kim, June-Koo Lee, Junseong Park, Eui Hyun Kim, Ji-Hyun Lee, Joon-Hyuk Lee, Won-Suk Chung, Young Seok Ju, Sung-Hong Park, Jong Hee Chang, Seok-Gu Kang, Jeong Ho Lee
Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall survival of fifteen months1,2 . Identifying the cell of origin that harbours mutations that drive GBM could provide a fundamental basis for understanding disease progression and developing new treatments. Given that the accumulation of somatic mutations has been implicated in gliomagenesis, studies have suggested that neural stem cells (NSCs), with their self-renewal and proliferative capacities, in the subventricular zone (SVZ) of the adult human brain may be the cells from which GBM originates3-5 ...
August 2018: Nature