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Venous Disease

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2 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27179058/in-hospital-management-and-follow-up-treatment-of-venous-thromboembolism-focus-on-new-and-emerging-treatments
#1
Joshua D Lenchus, Michelle Biehl, Jorge Cabrera, Alice Gallo de Moraes, Cameron Dezfulian
Venous thromboembolism (VTE), encompassing pulmonary embolism (PE) and deep venous thrombosis (DVT), is a major cause of morbidity and mortality of particular relevance for intensivists and hospitalists. Acute VTE is usually managed with parenteral unfractionated heparin or low-molecular-weight heparin, followed by an oral vitamin K antagonist. Data are lacking for optimal treatment of less common occurrences, such as upper extremity DVT, and for approaches such as thrombolysis for PE associated with early signs of hemodynamic compromise or inferior vena cava filters when anticoagulation is contraindicated...
May 13, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/26727005/non-vitamin-k-oral-anticoagulants-versus-warfarin-for-patients-with-atrial-fibrillation-absolute-benefit-and-harm-assessments-yield-novel-insights
#2
REVIEW
Cyrus R Kumana, Bernard M Y Cheung, David C W Siu, Hung-Fat Tse, Ian J Lauder
BACKGROUND AND OBJECTIVES: Benefits and/or harms (including costs) of non-vitamin K oral anticoagulants (NOACs) versus warfarin therapy need appreciation in relative and absolute terms. METHODS: Accordingly, we derived clinically relevant relative and absolute benefit/harm parameters for NOACs (apixaban, dabigatran, rivaroxaban, edoxaban) compared to warfarin from four clinical trials involving atrial fibrillation (AF) patients. For each trial, we tabulated patient numbers enduring four important outcomes and calculated unadjusted relative risk reduction (RRR) and number needed to treat (NNT)/year values (and 95% confidence intervals) for the NAOC compared to warfarin...
April 2016: Cardiovascular Therapeutics
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