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6 papers 25 to 100 followers
J Cobb Scott, Samantha T Slomiak, Jason D Jones, Adon F G Rosen, Tyler M Moore, Ruben C Gur
Importance: Substantial shifts in perception and policy regarding cannabis have recently occurred, with use of cannabis increasing while its perceived harm decreases. One possible risk of increased cannabis use is poorer cognitive functioning, especially in youth. Objective: To provide the first quantitative synthesis of the literature examining cannabis and cognitive functioning in adolescents and young adults (with a mean age of 26 years and younger). Data Sources: PubMed, PsycInfo, Academic Search Premier, Scopus, and bibliographies of relevant reviews were searched for peer-reviewed, English-language studies from the date the databases began through May 2017...
June 1, 2018: JAMA Psychiatry
Jordan Bechtold, Alison Hipwell, David A Lewis, Rolf Loeber, Dustin Pardini
OBJECTIVE: Adolescents who regularly use marijuana may be at heightened risk of developing subclinical and clinical psychotic symptoms. However, this association could be explained by reverse causation or other factors. To address these limitations, the current study examined whether adolescents who engage in regular marijuana use exhibit a systematic increase in subclinical psychotic symptoms that persists during periods of sustained abstinence. METHOD: The sample comprised 1,009 boys who were recruited in 1st and 7th grades...
August 1, 2016: American Journal of Psychiatry
Nora D Volkow, James M Swanson, A Eden Evins, Lynn E DeLisi, Madeline H Meier, Raul Gonzalez, Michael A P Bloomfield, H Valerie Curran, Ruben Baler
With a political debate about the potential risks and benefits of cannabis use as a backdrop, the wave of legalization and liberalization initiatives continues to spread. Four states (Colorado, Washington, Oregon, and Alaska) and the District of Columbia have passed laws that legalized cannabis for recreational use by adults, and 23 others plus the District of Columbia now regulate cannabis use for medical purposes. These policy changes could trigger a broad range of unintended consequences, with profound and lasting implications for the health and social systems in our country...
March 2016: JAMA Psychiatry
Barbara J Weiland, Rachel E Thayer, Brendan E Depue, Amithrupa Sabbineni, Angela D Bryan, Kent E Hutchison
Recent research has suggested that marijuana use is associated with volumetric and shape differences in subcortical structures, including the nucleus accumbens and amygdala, in a dose-dependent fashion. Replication of such results in well controlled studies is essential to clarify the effects of marijuana. To that end, this retrospective study examined brain morphology in a sample of adult daily marijuana users (n = 29) versus nonusers (n = 29) and a sample of adolescent daily users (n = 50) versus nonusers (n = 50)...
January 28, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Nora D Volkow, Gene-Jack Wang, Frank Telang, Joanna S Fowler, David Alexoff, Jean Logan, Millard Jayne, Christopher Wong, Dardo Tomasi
Moves to legalize marijuana highlight the urgency to investigate effects of chronic marijuana in the human brain. Here, we challenged 48 participants (24 controls and 24 marijuana abusers) with methylphenidate (MP), a drug that elevates extracellular dopamine (DA) as a surrogate for probing the reactivity of the brain to DA stimulation. We compared the subjective, cardiovascular, and brain DA responses (measured with PET and [(11)C]raclopride) to MP between controls and marijuana abusers. Although baseline (placebo) measures of striatal DA D2 receptor availability did not differ between groups, the marijuana abusers showed markedly blunted responses when challenged with MP...
July 29, 2014: Proceedings of the National Academy of Sciences of the United States of America
Nora D Volkow, Ruben D Baler, Wilson M Compton, Susan R B Weiss
In light of the rapidly shifting landscape regarding the legalization of marijuana for medical and recreational purposes, patients may be more likely to ask physicians about its potential adverse and beneficial effects on health. The popular notion seems to be that marijuana is a harmless pleasure,..
June 5, 2014: New England Journal of Medicine
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