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14 papers 0 to 25 followers
Ondřej Kubeček, Jan Laco, Jiří Špaček, Jiří Petera, Jindřich Kopecký, Alena Kubečková, Stanislav Filip
Secondary tumors of the ovary account for 10-25% of all ovarian malignancies. The most common tumors that give rise to ovarian metastases include breast, colorectal, endometrial, stomach, and appendix cancer. The correct diagnosis of secondary ovarian tumors may be challenging as they are not infrequently misdiagnosed as primary ovarian cancer, particularly in the case of mucinous adenocarcinomas. The distinction from the latter is essential, as it requires different treatment. Immunohistochemistry plays an important role in distinguishing primary ovarian tumors from extra-ovarian metastases and, furthermore, may suggest the primary tumor site...
June 2017: Clinical & Experimental Metastasis
Kaitlyn J Kelly
Primary cancers of the appendix are rare and are frequently diagnosed after surgery for appendicitis, presumed ovarian primary malignancy, or other indications. Primary appendix cancers are histologically diverse, and classification of these tumors has historically been confusing because of the nonstandardized nomenclature that is used. This review aimed to describe the epidemiology, presentation, workup, staging, and management of primary appendix cancers using current, recommended nomenclature. For this purpose, tumors were broadly classified as colonic-type or mucinous adenocarcinoma, goblet cell adenocarcinoma, or neuroendocrine carcinoma...
December 2015: Clinics in Colon and Rectal Surgery
Delphine L Chen, Joseph Cheriyan, Edwin R Chilvers, Gourab Choudhury, Christopher Coello, Martin Connell, Marie Fisk, Ashley M Groves, Roger N Gunn, Beverley F Holman, Brian F Hutton, Sarah Lee, William MacNee, Divya Mohan, David Parr, Deepak Subramanian, Ruth Tal-Singer, Kris Thielemans, Edwin J R van Beek, Laurence Vass, Jeremy W Wellen, Ian Wilkinson, Frederick J Wilson
Millions of people are affected by respiratory diseases, leading to a significant health burden globally. Because of the current insufficient knowledge of the underlying mechanisms that lead to the development and progression of respiratory diseases, treatment options remain limited. To overcome this limitation and understand the associated molecular changes, noninvasive imaging techniques such as PET and SPECT have been explored for biomarker development, with (18)F-FDG PET imaging being the most studied. The quantification of pulmonary molecular imaging data remains challenging because of variations in tissue, air, blood, and water fractions within the lungs...
February 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Frank C Detterbeck, Daniel J Boffa, Anthony W Kim, Lynn T Tanoue
Stage classification provides a nomenclature about the anatomic extent of a cancer; a consistent language provides the ability to communicate about a specific patient and about cohorts of patients in clinical studies. This paper summarizes the eighth edition of lung cancer stage classification, which is the worldwide standard as of January 1, 2017. This revision is based on a large global database, a sophisticated analysis, extensive internal validation as well as multiple assessments confirming generalizability...
January 2017: Chest
S Zouine, F Marnissi, N Otmani, M Bennani Othmani, M El Wafi, K Kojok, Y Zaid, N Tahiri Jouti, N Habti
The association between blood groups ABO and different types of diseases was established in several previous studies. Our aim was to seek the possible association between the ABO blood group and breast cancer-associated prognostic factors. The Chi-squared analytic test was used to compare phenotypic ABO distribution among Moroccan blood donors and 442 cases of women suffering from breast carcinoma with archived files in Maternity Ward of University Hospital C.H.U Ibn Rochd between 2008 and 2011. High incidence of breast carcinoma was observed in blood type B patients (p < 0...
July 2016: Medical Oncology
Amelia O Clive, Hayley E Jones, Rahul Bhatnagar, Nancy J Preston, Nick Maskell
BACKGROUND: Malignant pleural effusion (MPE) is a common problem for people with cancer as a result of malignant infiltration of the pleura. It is usually associated with considerable breathlessness. A number of treatment options are available to manage the uncontrolled accumulation of pleural fluid including administration of a pleurodesis agent (either via a chest tube or at thoracoscopy) or indwelling pleural catheter insertion. OBJECTIVES: To ascertain the optimal management strategy for adults with malignant pleural effusion in terms of pleurodesis success...
May 8, 2016: Cochrane Database of Systematic Reviews
Muhammad Usman Ali, John Miller, Leslea Peirson, Donna Fitzpatrick-Lewis, Meghan Kenny, Diana Sherifali, Parminder Raina
OBJECTIVES: To examine evidence on benefits and harms of screening average to high-risk adults for lung cancer using chest radiology (CXR), sputum cytology (SC) and low-dose computed tomography (LDCT). METHODS: This systematic review was conducted to provide up to date evidence for Canadian Task Force on Preventive Health Care (CTFPHC) lung cancer screening guidelines. Four databases were searched to March 31, 2015 along with utilizing a previous Cochrane review search...
August 2016: Preventive Medicine
Annette McWilliams, Martin C Tammemagi, John R Mayo, Heidi Roberts, Geoffrey Liu, Kam Soghrati, Kazuhiro Yasufuku, Simon Martel, Francis Laberge, Michel Gingras, Sukhinder Atkar-Khattra, Christine D Berg, Ken Evans, Richard Finley, John Yee, John English, Paola Nasute, John Goffin, Serge Puksa, Lori Stewart, Scott Tsai, Michael R Johnston, Daria Manos, Garth Nicholas, Glenwood D Goss, Jean M Seely, Kayvan Amjadi, Alain Tremblay, Paul Burrowes, Paul MacEachern, Rick Bhatia, Ming-Sound Tsao, Stephen Lam
BACKGROUND: Major issues in the implementation of screening for lung cancer by means of low-dose computed tomography (CT) are the definition of a positive result and the management of lung nodules detected on the scans. We conducted a population-based prospective study to determine factors predicting the probability that lung nodules detected on the first screening low-dose CT scans are malignant or will be found to be malignant on follow-up. METHODS: We analyzed data from two cohorts of participants undergoing low-dose CT screening...
September 5, 2013: New England Journal of Medicine
Hiren J Mehta, James G Ravenel, Stephanie R Shaftman, Nichole T Tanner, Luca Paoletti, Katherine K Taylor, Martin C Tammemagi, Mario Gomez, Paul J Nietert, Michael K Gould, Gerard A Silvestri
BACKGROUND: An estimated 150,000 pulmonary nodules are identified each year, and the number is likely to increase given the results of the National Lung Screening Trial. Decision tools are needed to help with the management of such pulmonary nodules. We examined whether adding any of three novel functions of nodule volume improves the accuracy of an existing malignancy prediction model of CT scan-detected nodules. METHODS: Swensen's 1997 prediction model was used to estimate the probability of malignancy in CT scan-detected nodules identified from a sample of 221 patients at the Medical University of South Carolina between 2006 and 2010...
March 1, 2014: Chest
Linda L Humphrey, Mark Deffebach, Miranda Pappas, Christina Baumann, Kathryn Artis, Jennifer Priest Mitchell, Bernadette Zakher, Rongwei Fu, Christopher G Slatore
BACKGROUND: Lung cancer is the leading cause of cancer-related death in the United States. Because early-stage lung cancer is associated with lower mortality than late-stage disease, early detection and treatment may be beneficial. PURPOSE: To update the 2004 review of screening for lung cancer for the U.S. Preventive Services Task Force, focusing on screening with low-dose computed tomography (LDCT). DATA SOURCES: MEDLINE (2000 to 31 May 2013), the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews (through the fourth quarter of 2012), Scopus, and reference lists...
September 17, 2013: Annals of Internal Medicine
Stephanie A Kovalchik, Martin Tammemagi, Christine D Berg, Neil E Caporaso, Tom L Riley, Mary Korch, Gerard A Silvestri, Anil K Chaturvedi, Hormuzd A Katki
BACKGROUND: In the National Lung Screening Trial (NLST), screening with low-dose computed tomography (CT) resulted in a 20% reduction in lung-cancer mortality among participants between the ages of 55 and 74 years with a minimum of 30 pack-years of smoking and no more than 15 years since quitting. It is not known whether the benefits and potential harms of such screening vary according to lung-cancer risk. METHODS: We assessed the variation in efficacy, the number of false positive results, and the number of lung-cancer deaths prevented among 26,604 participants in the NLST who underwent low-dose CT screening, as compared with the 26,554 participants who underwent chest radiography, according to the quintile of 5-year risk of lung-cancer death (ranging from 0...
July 18, 2013: New England Journal of Medicine
Richard Wender, Elizabeth T H Fontham, Ermilo Barrera, Graham A Colditz, Timothy R Church, David S Ettinger, Ruth Etzioni, Christopher R Flowers, G Scott Gazelle, Douglas K Kelsey, Samuel J LaMonte, James S Michaelson, Kevin C Oeffinger, Ya-Chen Tina Shih, Daniel C Sullivan, William Travis, Louise Walter, Andrew M D Wolf, Otis W Brawley, Robert A Smith
Findings from the National Cancer Institute's National Lung Screening Trial established that lung cancer mortality in specific high-risk groups can be reduced by annual screening with low-dose computed tomography. These findings indicate that the adoption of lung cancer screening could save many lives. Based on the results of the National Lung Screening Trial, the American Cancer Society is issuing an initial guideline for lung cancer screening. This guideline recommends that clinicians with access to high-volume, high-quality lung cancer screening and treatment centers should initiate a discussion about screening with apparently healthy patients aged 55 years to 74 years who have at least a 30-pack-year smoking history and who currently smoke or have quit within the past 15 years...
March 2013: CA: a Cancer Journal for Clinicians
Omar Lababede, Moulay Meziane, Thomas Rice
Lung cancer remains the most common cause of cancer-related death in the United States. TNM staging, which is an important guide to the prognosis and treatment of lung cancer, has been revised recently. In this article, we propose a quick reference chart and diagrams that consolidate TNM staging information in a simple format. The current classification of lymph node stations and zones is illustrated as well.
January 2011: Chest
Martin D Ogwang, Kishor Bhatia, Robert J Biggar, Sam M Mbulaiteye
Endemic Burkitt lymphoma (BL) is etiologically associated with Epstein-Barr virus and ecologically linked to Plasmodium falciparum malaria. However, these infections imperfectly correlate with BL epidemiology. To obtain recent epidemiological data, we studied district- and county-specific BL incidence and standardized incidence ratios using data collected from 1997 to 2006 at Lacor Hospital in northern Uganda, where studies were last done more than 30 years ago. Among 500 patients, median age was 6 years (interquartile range 5-8) and male-to-female ratio was 1...
December 1, 2008: International Journal of Cancer. Journal International du Cancer
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