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Measure GFR

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120 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29762739/ckd-staging-with-cystatin-c-or-creatinine-based-formulas-flipping-the-coin
#1
Sergio Luis-Lima, Beatriz Escamilla-Cabrera, Natalia Negrín-Mena, Sara Estupiñán, Patricia Delgado-Mallén, Domingo Marrero-Miranda, Ana González-Rinne, Rosa Miquel-Rodríguez, María Ángeles Cobo-Caso, Manuel Hernández-Guerra, Juana Oramas, Norberto Batista, Ana Aldea-Perona, Pablo Jorge-Pérez, Carlos González-Alayón, Miguel Moreno-Sanfiel, Juan Antonio González-Rodríguez, Laura Henríquez, Raquel Alonso-Pescoso, Laura Díaz-Martín, Federico González-Rinne, Bernardo Alio Lavín-Gómez, Judith Galindo-Hernández, Macarena Sánchez-Gallego, Alejandra González-Delgado, Alejandro Jiménez-Sosa, Armando Torres, Esteban Porrini
Background: Chronic kidney disease (CKD) affects 10-13% of the population worldwide. CKD classification stratifies patients in five stages of risk for progressive renal disease based on estimated glomerular filtration rate (eGFR) by formulas and albuminuria. However, the reliability of formulas to reflect real renal function is a matter of debate. The effect of the error of formulas in the CKD classification is unclear, particularly for cystatin C-based equations. Methods: We evaluated the reliability of a large number of cystatin C and/or creatinine-based formulas in the definition of the stages of CKD in 882 subjects with different clinical situations over a wide range of glomerular filtration rates (GFRs) (4...
May 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29748326/a-novel-method-for-rapid-bedside-measurement-of-gfr
#2
Dana V Rizk, Daniel Meier, Ruben M Sandoval, Teresa Chacana, Erinn S Reilly, Jesse C Seegmiller, Emmanuel DeNoia, James S Strickland, Joseph Muldoon, Bruce A Molitoris
Background Direct quantitative measurement of GFR (mGFR) remains a specialized task primarily performed in research settings. Multiple formulas for estimating GFR have been developed that use the readily available endogenous biomarkers creatinine and/or cystatin C. However, eGFR formulas have limitations, and an accurate mGFR is necessary in some clinical situations and for certain patient populations. We conducted a prospective, open-label study to evaluate a novel rapid technique for determining plasma volume and mGFR...
May 10, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29718360/metabolomic-profiling-to-improve-glomerular-filtration-rate-estimation-a-proof-of-concept-study
#3
Josef Coresh, Lesley A Inker, Yingying Sang, Jingsha Chen, Tariq Shafi, Wendy S Post, Michael G Shlipak, Lisa Ford, Kelli Goodman, Regis Perichon, Tom Greene, Andrew S Levey
Background: Estimation of glomerular filtration rate (GFR) using estimated glomerular filtration rate creatinine (eGFRcr) is central to clinical practice but has limitations. We tested the hypothesis that serum metabolomic profiling can identify novel markers that in combination can provide more accurate GFR estimates. Methods: We performed a cross-sectional study of 200 African American Study of Kidney Disease and Hypertension (AASK) and 265 Multi-Ethnic Study of Atherosclerosis (MESA) participants with measured GFR (mGFR)...
April 30, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29680822/disparities-in-the-estimation-of-glomerular-filtration-rate-according-to-cockcroft-gault-modification-of-diet-in-renal-disease-4-and-chronic-kidney-disease-epidemiology-collaboration-equations-and-relation-with-outcomes-in-patients-with-acute-coronary-syndrome
#4
José Miguel Rivera-Caravaca, Juan Miguel Ruiz-Nodar, Antonio Tello-Montoliu, María Asunción Esteve-Pastor, Miriam Quintana-Giner, Andrea Véliz-Martínez, Esteban Orenes-Piñero, Ana Isabel Romero-Aniorte, Nuria Vicente-Ibarra, Vicente Pernias-Escrig, Luna Carrillo-Alemán, Elena Candela-Sánchez, Ignacio Hortelano, Beatriz Villamía, Miriam Sandín-Rollán, Laura Nuñez-Martínez, Mariano Valdés, Francisco Marín
BACKGROUND: A simple method to assess renal function is the estimated glomerular filtration rate, and it shows prognostic implications. However, it remains unknown which equation should be used in patients with acute coronary syndrome. We compared the ability and correlation of the Cockcroft-Gault, Modification of Diet in Renal Disease-4 (MDRD-4), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations and their predictive performance for major adverse cardiovascular events, all-cause mortality, and major bleeding in a cohort of patients with acute coronary syndrome...
April 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29670671/the-association-between-glomerular-filtration-rate-estimated-using-different-equations-and-mortality-in-the-japanese-community-based-population-the-yamagata-takahata-study
#5
Asami Kabasawa, Tsuneo Konta, Natsuko Suzuki, Keita Kamei, Sayumi Watanabe, Akira Araumi, Eri Matsuki, Soichiro Kon, Midori Oyama, Kazunobu Ichikawa, Kenichi Ishizawa, Yoshiyuki Ueno, Hidetoshi Yamashita, Takamasa Kayama, Isao Kubota
Background: To evaluate renal function, the indices of estimated glomerular filtration rate (eGFR) obtained using several equations, including the Japanese versions of the serum creatinine-based MDRD equation (eGFRcreat), Chronic Kidney Disease Epidemiology Collaboration equation (eGFR-EPI), and serum cystatin C-based equation (eGFRcys), are utilized. This study prospectively examined the association between these eGFR values and all-cause mortality during a 12-year observational period in a community-based population...
2018: Disease Markers
https://www.readbyqxmd.com/read/29660234/evaluation-of-chronic-kidney-disease-in-cancer-patients-is-there-a-preferred-estimation-formula
#6
Ghassan Sleilalty, Elie El Rassy, Tarek Assi, Nathalie Al Rassy, Jessica Naseh, Jamale Rizkallah, Serge Finianos, Hiba Azar, Dania Nehme Chelala, Fadi El Karak, Joseph Kattan, Marwan Ghosn
BACKGROUND: The evaluation of chronic kidney disease in cancer patients seems to rely mostly on the Cockcroft-Gault (CG) formula or the creatinine levels to adjust treatment dosages which is a practice refuted by internists. AIMS: We evaluate the overall agreement of the CG, MDRD and CKD-EPI equation with the newly devised Janowitz and Williams' (JW) equation. METHODS: The renal function was estimated in 235 cancer patients according to the CG, MDRD, body surface area (BSA)-adjusted MDRD, CKD-EPI, BSA-adjusted CKD-EPI and JW formulae...
April 16, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29650358/prognostic-relevance-of-glomerular-filtration-rate-estimation-obtained-through-different-equations-in-hospitalized-elderly-patients
#7
Paolo Gallo, Antonio De Vincentis, Claudio Pedone, Alessandro Nobili, Mauro Tettamanti, Umberto Vespasiani Gentilucci, Antonio Picardi, Pier Mannuccio Mannucci, Raffaele Antonelli Incalzi
The estimated glomerular filtration rate (eGFR) is a predictor of important outcomes and its reduction has been associated with the risk of all-cause mortality in both general population and elderly patients. However while reduced renal function is common in older people, the best method for estimating GFR remains unclear, especially in an acute care setting. Most studies analyzing the accuracy of eGFR in the elderly were carried out in different heterogeneous settings. In this study, we compare the prognostic value of different formulas estimating GFR in predicting the risk of in-hospital morbidity and mortality within 3 months from discharge in elderly hospitalized patients...
April 9, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28920703/prognostic-usefulness-of-an-age-adapted-equation-for-renal-function-assessment-in-older-patients-with-acute-coronary-syndrome
#8
Lucía Rioboo Lestón, Emad Abu-Assi, Sergio Raposeiras-Roubin, Rafael Cobas-Paz, Berenice Caneiro-Queija, Jose Manuel Rodríguez-Rodríguez, Andres Íñiguez-Romo
BACKGROUND: Renal dysfunction negatively impacts survival in acute coronary syndrome patients. The Berlin Initiative Study creatinine-based (BIScrea) equation has recently been proposed for renal function assessment in older persons. However, up to now it is unknown if the superiority of the new BIScrea equation, with respect to the most recommended chronic kidney disease epidemiology collaboration creatinine-based (CKD-EPIcrea) formula, would translate into better risk prediction of adverse events in older patients with acute coronary syndrome...
September 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29609874/-detection-of-chronic-kidney-disease-using-estimated-glomerular-filtration-and-urine-albumin-are-we-complying-with-the-recommendations-of-the-guidelines
#9
Jose Luis Górriz, Maria Jesús Puchades
No abstract text is available yet for this article.
March 2018: Semergen
https://www.readbyqxmd.com/read/26630928/the-chronic-kidney-disease-epidemiology-collaboration-ckd-epi-equation-does-not-improve-the-underestimation-of-glomerular-filtration-rate-gfr-in-people-with-diabetes-and-preserved-renal-function
#10
Richard J MacIsaac, Elif I Ekinci, Erosha Premaratne, Zhong X Lu, Jas-Mine Seah, Yue Li, Ray Boston, Glenn M Ward, George Jerums
BACKGROUND: Our hypothesis was that both the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations would underestimate directly measured GFR (mGFR) to a similar extent in people with diabetes and preserved renal function. METHODS: In a cross-sectional study, bias (eGFR - mGFR) was compared for the CKD-EPI and MDRD equations, after stratification for mGFR levels. We also examined the ability of the CKD-EPI compared with the MDRD equation to correctly classify subjects to various CKD stages...
December 3, 2015: BMC Nephrology
https://www.readbyqxmd.com/read/26602880/-dosing-adjustment-and-renal-function-which-equation-s
#11
Pierre Delanaye, Martin Flamant, Étienne Cavalier, Fabrice Guerber, Thomas Vallotton, Olivier Moranne, Hans Pottel, Jean-Jacques Boffa, Christophe Mariat
While the CKD-EPI (for Chronic Kidney Disease Epidemiology) equation is now implemented worldwide, utilization of the Cockcroft formula is still advocated by some physicians for drug dosage adjustment. Justifications for this recommendation are that the Cockcroft formula was preferentially used to determine dose adjustments according to renal function during the development of many drugs, better predicts drugs-related adverse events and decreases the risk of drug overexposure in the elderly. In this opinion paper, we discuss the weaknesses of the rationale supporting the Cockcroft formula and endorse the French HAS (Haute Autorité de santé) recommendation regarding the preferential use of the CKD-EPI equation...
February 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/26392392/renal-function-and-diffusion-weighted-imaging-a-new-method-to-diagnose-kidney-failure-before-losing-half-function
#12
Türker Emre, Özgür Kiliçkesmez, Atılay Büker, Berrin Berçik İnal, Hüseyin Doğan, Tevfik Ecder
AIM: To diagnose earlier kidney failure, we investigated renal functions with diffusion-weighted imaging (DWI). METHODS: We evaluated the DWI of 62 patients with chronic kidney disease (CKD) and compared it with creatinine clearance provided by daily urine collection. The apparent diffusion coefficient (ADC) values were compared with the five stages of CKD. RESULTS: For each stage of CKD, the ADC values were found to be significantly different (p < 0...
March 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/26211499/a-retrospective-analysis-of-kidney-function-and-risk-factors-by-chronic-kidney-disease-epidemiology-collaboration-ckd-epi-equation-in-elderly-chinese-patients
#13
Wei Liu, Feng Yu, Yanhua Wu, Xiaowu Fang, Wenxue Hu, Jian Chen, Ruili Zhou, Xinge Lin, Wenke Hao
Chronic kidney disease accounts for much of the increased mortality, especially in the elder population. The prevalence of this disease is expected to increase significantly as the society ages. Our aim was to evaluate the kidney function and risk factors of reduced renal function among elderly Chinese patients. This study retrospectively collected clinical data from a total of 1062 inpatients aged 65 years or over. Estimated glomerular filtration rate (eGFR) was calculated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation...
2015: Renal Failure
https://www.readbyqxmd.com/read/28183270/estimation-of-renal-function-by-ckd-epi-versus-mdrd-in-a-cohort-of-hiv-infected-patients-a-cross-sectional-analysis
#14
COMPARATIVE STUDY
M P Cristelli, F Cofán, N Rico, J C Trullàs, C Manzardo, F Agüero, J L Bedini, A Moreno, F Oppenheimer, J M Miro
BACKGROUND: Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has greater diagnostic accuracy. To date, however, little information exists on patients with HIV-infection. This study aimed to evaluate eGFR by CKD-EPI vs. MDRD equations and to stratify renal function according to KDIGO guidelines...
February 10, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29261774/aging-and-decreased-glomerular-filtration-rate-an-elderly-population-based-study
#15
Regina C R M Abdulkader, Emmanuel A Burdmann, Maria Lúcia Lebrão, Yeda A O Duarte, Dirce M T Zanetta
BACKGROUND: Although a reduced glomerular filtration rate (GFR) in old people has been attributed to physiologic aging, it may be associated with kidney disease or superimposed comorbidities. This study aims to assess the prevalence of decreased GFR in a geriatric population in a developing country and its prevalence in the absence of simultaneous diseases. STUDY DESIGN AND METHODS: This is a cross-sectional study of data from the Saúde, Bem-Estar e Envelhecimento cohort study (SABE study[Health, Well-Being and Aging]), a multiple cohorts study...
2017: PloS One
https://www.readbyqxmd.com/read/29332011/examining-the-utility-of-cystatin-c-as-a-confirmatory-test-of-chronic-kidney-disease-across-the-age-range-in-middle-aged-and-older-community-dwelling-adults
#16
Mark Canney, Donal J Sexton, Neil O'Leary, Martin Healy, Rose Anne Kenny, Mark A Little, Conall M O'Seaghdha
BACKGROUND: Cystatin C has been proposed as a confirmatory test of chronic kidney disease (CKD). This is most applicable to older individuals with CKD, the majority of whom have a creatinine-based estimated glomerular filtration rate (eGFR) of 45-59 mL/min/1.73 m2 (CKD stage 3a). We sought to examine the utility of cystatin C as a confirmatory test of CKD across the age range in the general population of older adults. METHODS: Cross-sectional analysis of 5386 participants from The Irish Longitudinal Study on Ageing, a cluster-sampled national cohort of community-dwelling adults aged ≥50 years...
April 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29579819/correlation-of-the-glomerular-filtration-rate-measured-with-the-use-of-dtpa-tc99m-in-live-kidney-donors-with-equations-based-on-creatinine-and-cystatin-c
#17
L Garcia-Covarrubias, J Barragan, I Castro, K Hernandez, A Reding, H Hinojosa, P Prieto, A Garcia, C Alejandra, D Ortuño, M Carmona, D Fernández, H Diliz
BACKGROUND: Renal donation leads to a risk of developing chronic kidney disease, with an incidence of 0.47%. To evaluate for its presence, formulas based on serum creatinine are used, but up to 80% of these formulas underestimate the glomerular filtration rate (GFR) in donors. The aim of this work was to confirm the highest correlation of the GFR as measured with the use of DTPA-Tc99m with the GFR as estimated by means of the formula based on serum cystatin C (CKD-EPI creatinine-cystatin C) in healthy kidney donors...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29499890/estimated-glomerular-filtration-rate-laboratory-implementation-and-current-global-status
#18
REVIEW
W Greg Miller, Graham R D Jones
In 2002, the Kidney Disease Outcomes Quality Initiative guidelines for identifying and treating CKD recommended that clinical laboratories report estimated glomerular filtration rate (eGFR) with every creatinine result to assist clinical practitioners to identify people with early-stage CKD. At that time, the original Modification of Diet in Renal Disease (MDRD) Study equation based on serum creatinine measurements was recommended for calculating eGFR. Because the MDRD Study equation was developed using a nonstandardized creatinine method, a Laboratory Working Group of the National Kidney Disease Education program was formed and implemented standardized calibration traceability for all creatinine methods from global manufacturers by approximately 2010...
January 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29484708/comparing-different-estimated-glomerular-filtration-rate-equations-in-assessing-glomerular-function-in-children-based-on-creatinine-and-cystatin-c
#19
Seçil Conkar, Sevgi Mir, Fatma Nur Karaslan, Gülden Hakverdi
BACKGROUND: Glomerular filtration rate (GFR) is the best marker used to assess renal function. Estimated GFR (eGFR) equations have been developed, and the ideal formula is still under discussion. We wanted to find the most practical and reliable GFR in eGFR formulas. We compared serum creatinine (Scr)- and cystatin C (cysC)-based eGFR formulas in the literature. We also aimed to determine the suitability and the reliability of cysC for practical use in determining GFR in children. METHODS: We have enrolled 238 children in the study...
February 27, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29464547/comparative-evaluation-of-technetium-99m-diethylenetriaminepentaacetic-acid-renal-dynamic-imaging-versus-the-modification-of-diet-in-renal-disease-equation-and-the-chronic-kidney-disease-epidemiology-collaboration-equation-for-the-estimation-of-gfr
#20
Qi Huang, Yunshuang Chen, Min Zhang, Sihe Wang, Weiguang Zhang, Guangyan Cai, Xiangmei Chen, Xuefeng Sun
PURPOSE: We compared the performance of technetium-99m-diethylenetriaminepentaacetic acid (99m Tc-DTPA) renal dynamic imaging (RDI), the MDRD equation, and the CKD EPI equation to estimate glomerular filtration rate (GFR). METHODS: A total of 551 subjects, including CKD patients and healthy individuals, were enrolled in this study. Dual plasma sample clearance method of 99m Tc-DTPA was used as the true value for GFR (tGFR). RDI and the MDRD and CKD EPI equations for estimating GFR were compared and evaluated...
April 2018: International Urology and Nephrology
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