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Robert L Rosenfield, David A Ehrmann
Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989-1995. Subsequent studies have supported and amplified this hypothesis. When defined as otherwise unexplained hyperandrogenic oligoanovulation, two-thirds of PCOS cases have functionally typical FOH, characterized by 17-hydroxyprogesterone hyperresponsiveness to gonadotropin stimulation. Two-thirds of the remaining PCOS have FOH detectable by testosterone elevation after suppression of adrenal androgen production...
October 2016: Endocrine Reviews
Agnieszka Szypowska, Anke Schwandt, Jannet Svensson, Shlomit Shalitin, Roque Cardona-Hernandez, Gun Forsander, Frida Sundberg, Carine De Beaufort, David Maahs, Claudio Maffeis, Stephen M P O'Riordan, Iveta Dzivite Krisane, Mauro Scharf, Sofia Castro, Maia Konstantinova, Barbora Obermannova, Kristina Casteels, Damla Gökşen, Júlia Galhardo, Christina Kanaka-Gantenbein, Birgit Rami-Merhar, Laszlo Madacsy
BACKGROUND: Intensified insulin delivery using multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII) is recommended in children with type 1 diabetes (T1D) to achieve good metabolic control. OBJECTIVE: To examine the frequency of pump usage in T1D children treated in SWEET (Better control in Paediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference) centers and to compare metabolic control between patients treated with CSII vs MDI...
July 15, 2016: Pediatric Diabetes
Amy K Mottl, Jasmin Divers, Dana Dabelea, David M Maahs, Lawrence Dolan, David Pettitt, Santica Marcovina, Giuseppina Imperatore, Catherine Pihoker, Michael Mauer, Elizabeth J Mayer-Davis
BACKGROUND: Insulin resistance is associated with microalbuminuria among youth with diabetes mellitus. We sought to determine the dose-response effect of insulin sensitivity (IS) on the magnitude of albuminuria and whether there is a threshold below which urine albumin excretion increases. METHODS: These analyses included participants from the SEARCH for Diabetes in Youth Study with incident diabetes who completed a baseline study visit (n = 2988). We estimated IS using a validated equation incorporating waist circumference, HbA1C, and fasting serum triglycerides...
June 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Marion Keller, Radhouène Attia, Jacques Beltrand, Juliette Djadi-Prat, Thao Nguyen-Khoa, Jean-Philippe Jay, Michel Cahané, Carine Choleau, Jean-Jacques Robert
OBJECTIVES: To further describe the changes in insulin therapy regimens and hemoglobin A1c (HbA1c) in children and adolescents with type 1 diabetes, and their associations with diabetes knowledge and quality of life. RESEARCH DESIGN AND METHODS: The study included 4293 children and adolescents (12.9 ± 2.6 yr, diabetes >1 yr) attending AJD (Aide aux Jeunes Diabétiques) summer camps between 2009 and 2014. The distribution of insulin regimens and associations between HbA1c, therapeutic regimens, diabetes knowledge (AJD questionnaire), and Quality of Life (Ingersoll et Marrero, Hvidoere Study Group short version) were assessed...
May 10, 2016: Pediatric Diabetes
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