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QTc Prolongation in Psychiatric Settings

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6 papers 0 to 25 followers
By Edwin Kim Resident Physician, Aspiring Addiction Psychiatrist
Tricia B Minton, Joanna Rosing, David S Spar, Jeffrey R Strawn, Blanca Garcia-Delgar, Barbara J Coffey
No abstract text is available yet for this article.
June 2016: Journal of Child and Adolescent Psychopharmacology
Tiziano Acciavatti, Giovanni Martinotti, Massimo di Giannantonio
No abstract text is available yet for this article.
May 2016: Journal of Clinical Psychiatry
Adam J Karz, Daniel P McGonigle, Joseph F Goldberg, Charles H Kellner, Brandon S Calenda
The use of neuroleptics in the elderly has been a topic of debate since 2005 when the US Food and Drug Administration issued a black-box warning of increased risk of mortality in elderly patients with dementia-related psychosis. Antipsychotic alternatives such as divalproex are sometimes favored on an "off-label" basis to manage agitation in the demented elderly, and antipsychotic use is often clinically necessary to treat psychosis in older adults, with or without dementia. Concurrently, risk for iatrogenic corrected QT (QTc) prolongation on electrocardiogram (ECG) remains a concern with the use of many antipsychotic agents because of its associated potential for fatal arrhythmias...
December 2015: Journal of Clinical Psychiatry
Stefan Unterecker, Bruno Pfuhlmann, Juliane Kopf, Sarah Kittel-Schneider, Andreas Reif, Jürgen Deckert
Electrocardiographic pathologies are a common problem during antidepressant treatment. The authors investigated the association of serum concentrations of antidepressants and heart rate, QT, and QTc. Polymorphisms of NOS1AP (nitric oxide synthase 1 adaptor protein) rs10494366 and rs12143842 as potential influence factors also were considered. In the amitriptyline sample (n = 59), significant Spearman ρ correlations were found between serum concentration and QTc (r = 0.333, P = 0.010), as well as heart rate (r = 0...
August 2015: Journal of Clinical Psychopharmacology
Mehrul Hasnain, W Victor R Vieweg
We comprehensively reviewed published literature to determine whether it supported the link between corrected QT (QTc) interval prolongation and torsade de pointes (TdP) for the 11 second-generation antipsychotics and seven second-generation antidepressants commonly implicated in these complications. Using PubMed and EMBASE, we identified four thorough QT studies (one each for iloperidone, ziprasidone, citalopram, and escitalopram), 40 studies specifically designed to assess QTc interval prolongation or TdP, 58 publications based on data from efficacy and safety trials, 18 toxicology studies, and 102 case reports...
October 2014: CNS Drugs
Scott R Beach, William J Kostis, Christopher M Celano, James L Januzzi, Jeremy N Ruskin, Peter A Noseworthy, Jeff C Huffman
OBJECTIVE: To evaluate the association between selective serotonin reuptake inhibitors (SSRIs) and corrected QT interval (QTc) prolongation via meta-analysis of prospective studies. DATA SOURCES: PubMed/MEDLINE database (January 1, 1975-August 15, 2012), with additional reports identified using hand searches of reference lists of relevant articles. Key words searched were QT, torsades de pointes, and sudden cardiac death, combined with antidepressants, citalopram, escitalopram, fluoxetine, sertraline, paroxetine, and fluvoxamine...
May 2014: Journal of Clinical Psychiatry
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