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CMBs and Stroke

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12 papers 0 to 25 followers
Andreas Charidimou, Duncan Wilson, Clare Shakeshaft, Gareth Ambler, Mark White, Hannah Cohen, Tarek Yousry, Rustam Al-Shahi Salman, Gregory Lip, Henry Houlden, Hans R Jäger, Martin M Brown, David J Werring
BACKGROUND AND RATIONALE: The increasing use of oral anticoagulants, mostly to prevent ischemic stroke due to atrial fibrillation in an ageing population, has been associated with a fivefold increased incidence of oral anticoagulant-associated intracerebral hemorrhage: a rare, serious, and unpredictable complication. We hypothesize that cerebral microbleeds and other markers of cerebral small vessel disease on magnetic resonance imaging, and genetic polymorphisms (e.g. influencing cerebral small vessel integrity or anticoagulation stability), are associated with an increased risk of oral anticoagulant-associated intracerebral hemorrhage, with potential to improve risk prediction...
October 2015: International Journal of Stroke: Official Journal of the International Stroke Society
Saloua Akoudad, Marileen L P Portegies, Peter J Koudstaal, Albert Hofman, Aad van der Lugt, M Arfan Ikram, Meike W Vernooij
BACKGROUND: Cerebral microbleeds are highly prevalent in people with clinically manifest cerebrovascular disease and have been shown to increase the risk of stroke recurrence. Microbleeds are also frequently found in healthy elderly, a population in which the clinical implication of microbleeds is unknown. METHODS AND RESULTS: In the population-based Rotterdam Study, the presence, number, and location of microbleeds were assessed at baseline on brain MRI of 4759 participants aged ≥45 years...
August 11, 2015: Circulation
Toshihide Naganuma, Yoshiaki Takemoto, Tetsuo Shoji, Eiji Ishimura, Mikio Okamura, Tatsuya Nakatani
BACKGROUND AND PURPOSE: In hemodialysis patients, previous reports have described a high prevalence of cerebral microbleeds (CMBs), but no longitudinal studies have been performed to determine the clinical significance of CMBs in these patients. In this study, we investigated whether the presence of CMBs was a predictor of future strokes in hemodialysis patients. METHODS: Cranial MRI, including T2*-weighted magnetic resonance imaging, was performed on 179 hemodialysis patients with no past history of cerebrovascular events...
August 2015: Stroke; a Journal of Cerebral Circulation
Marije R Benedictus, Niels D Prins, Jeroen D C Goos, Philip Scheltens, Frederik Barkhof, Wiesje M van der Flier
IMPORTANCE: Microbleeds are more prevalent in patients with Alzheimer disease (AD) compared with the general elderly population. In addition, microbleeds have been found to predict mortality in AD. OBJECTIVE: To investigate whether microbleeds in AD increase the risk for mortality, stroke (including intracerebral hemorrhage), and cardiovascular events. DESIGN, SETTING AND PARTICIPANTS: The MISTRAL (do MIcrobleeds predict STRoke in ALzheimer's disease) Study is a longitudinal cohort study within the memory clinic-based Amsterdam Dementia Cohort...
May 2015: JAMA Neurology
José Rafael Romero, Sarah R Preis, Alexa Beiser, Charles DeCarli, Anand Viswanathan, Sergi Martinez-Ramirez, Carlos S Kase, Philip A Wolf, Sudha Seshadri
BACKGROUND AND PURPOSE: Cerebral microbleeds (CMBs) are associated with increased risk of stroke and poor cognition. Vascular risk factors and medications used for stroke prevention may increase the risk of CMB. We examined the prevalence of CMB and the association of these risk factors with CMB, postulating that risk factors for cerebral amyloid angiopathy would be associated with lobar CMB and markers of hypertensive vasculopathy with deep CMB. METHODS: We include 1965 Framingham Original and Offspring participants (age, 66...
May 2014: Stroke; a Journal of Cerebral Circulation
T J Song, J Kim, Y D Kim, H S Nam, H S Lee, C M Nam, J H Heo
BACKGROUND AND PURPOSE: Increased arterial stiffness causes vessel damage in the end-organs. Therefore small vessels in the brain may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically or pathophysiologically categorized as deep or infratentorial type and strictly lobar type. Whether the presence and location of CMBs are associated with brachial-ankle pulse wave velocity (baPWV) which represents a measure of arterial stiffness was investigated...
March 2014: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Andreas Charidimou, Anant Krishnan, David J Werring, H Rolf Jäger
Cerebral microbleeds have emerged as an important new imaging marker of cerebral small vessel disease. With the development of MRI techniques that are exquisitely sensitive to paramagnetic blood products, such as T2*-weighted gradient-recalled echo and susceptibility-weighted sequences, microbleeds have been detected in ever-increasing numbers of patients in stroke and cognitive clinics, as well as in healthy older people and in a variety of other rarer diseases and syndromes. Detection of cerebral microbleeds has clinical implications with respect to the diagnosis of the underlying small vessel disease, the safety of antithrombotic use, and the risk of symptomatic intracerebral haemorrhage, cognitive impairment and dementia...
June 2013: Neuroradiology
Andreas Charidimou, Puneet Kakar, Zoe Fox, David J Werring
BACKGROUND AND PURPOSE: To evaluate cerebral microbleeds (CMBs) and future stroke risk (including intracerebral hemorrhage [ICH]) in patients with ischemic stroke (IS) or transient ischemic attack. MATERIALS AND METHODS: A systematic review and meta-analysis of prospective cohorts with recent IS/transient ischemic attack. We critically appraised studies and calculated pooled odds ratios (ORs), using the Mantel-Haenszel fixed-effects method, for ICH or recurrent IS, in patients with versus without CMBs...
April 2013: Stroke; a Journal of Cerebral Circulation
Hirokazu Bokura, Reiko Saika, Takuya Yamaguchi, Atsushi Nagai, Hiroaki Oguro, Shotai Kobayashi, Shuhei Yamaguchi
BACKGROUND AND PURPOSE: Cerebral microbleeds (MBs) are frequently detected in patients with stroke, especially those who experience intracerebral hemorrhage. However, the clinical significance of MBs in subjects without cerebrovascular disease is still unclear. We performed a prospective study to determine whether the presence of MBs provides useful prognostic information in healthy elderly individuals. METHODS: We tracked 2102 subjects (mean age, 62.1 years) over a mean interval of 3...
July 2011: Stroke; a Journal of Cerebral Circulation
Caroline E Lovelock, Charlotte Cordonnier, Hiromitsu Naka, Rustam Al-Shahi Salman, Cathie L M Sudlow, Takatoshi Sorimachi, David J Werring, Simone M Gregoire, Toshio Imaizumi, Seung-Hoon Lee, Dennis Briley, Peter M Rothwell
BACKGROUND AND PURPOSE: Cerebral microbleeds (MB) are potential risk factors for intracerebral hemorrhage (ICH), but it is unclear if they are a contraindication to using antithrombotic drugs. Insights could be gained by pooling data on MB frequency stratified by antithrombotic use in cohorts with ICH and ischemic stroke (IS)/transient ischemic attack (TIA). METHODS: We performed a systematic review of published and unpublished data from cohorts with stroke or TIA to compare the presence of MB in: (1) antithrombotic users vs nonantithrombotic users with ICH; (2) antithrombotic users vs nonusers with IS/TIA; and (3) ICH vs ischemic events stratified by antithrombotic use...
June 2010: Stroke; a Journal of Cerebral Circulation
S-B Jeon, S U Kwon, A-H Cho, S-C Yun, J S Kim, D-W Kang
BACKGROUND: It is unknown whether the development of cerebral microbleeds (MBs), small areas of signal loss on T2*-weighted gradient-echo imaging (GRE), follows a slow or a rapid process. We hypothesized that MBs may develop rapidly after certain critical events, such as strokes, and investigated the frequency, location, and factors associated with the formation of new MBs after acute ischemic stroke. METHODS: We retrospectively examined 237 consecutive acute ischemic stroke patients who underwent MRI within 24 hours and follow-up MRI during the week after symptom onset...
November 17, 2009: Neurology
W Kakuda, V N Thijs, M G Lansberg, R Bammer, L Wechsler, S Kemp, M E Moseley, M P Marks, G W Albers
BACKGROUND: Cerebral microbleeds (MBs) detected on gradient echo (GRE) imaging may be a risk factor for hemorrhagic complications in patients with stroke treated with IV tissue plasminogen activator (tPA). METHODS: The authors prospectively evaluated patients with acute ischemic stroke treated with IV tPA between 3 and 6 hours of symptom onset. MRI scans, including GRE imaging, were performed prior to tPA treatment, 3 to 6 hours after treatment and at day 30. The authors compared the frequency of hemorrhagic complications after thrombolysis in patients with and without MBs on their baseline GRE imaging...
October 25, 2005: Neurology
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