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Renal Pharmacology

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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Enrico Fiaccadori, Elio Antonucci, Santo Morabito, Antonio d'Avolio, Umberto Maggiore, Giuseppe Regolisti
Colistin (polymyxin E) is a mainly concentration-dependent bactericidal antimicrobial active against multidrug-resistant Gram-negative bacteria. After being abandoned over the past 30 years due to its neuro- and nephrotoxicity, colistin has been reintroduced recently as a last-resort drug for the treatment of multidrug-resistant Gram-negative bacteria infections in combination with other antimicrobials. Unfortunately, although renal toxicity is a well-known dose-related adverse effect of colistin, relatively few studies are currently available on its peculiar pharmacodynamic/pharmacokinetic properties in clinical settings at high risk for drug accumulation, such as acute or chronic kidney disease...
August 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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