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CDH

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8 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27228382/cardiopulmonary-exercise-performance-is-reduced-in-congenital-diaphragmatic-hernia-survivors
#1
Katarina Bojanić, Ruža Grizelj, Daniel Dilber, Dalibor Šarić, Jurica Vuković, Paolo T Pianosi, David J Driscoll, Toby N Weingarten, Ena Pritišanac, Darrell R Schroeder, Juraj Sprung
BACKGROUND: Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia. CDH survivors may have pulmonary morbidity that can decrease cardiopulmonary exercise. We aimed to examine whether cardiopulmonary exercise testing (CPET) results differ in CDH survivors versus healthy age-matched controls and whether CPET results among CDH survivors differ according to self-reported daily activity. METHODS: In one medical center in Croatia, CDH survivors-patients with surgically corrected CDH who were alive at age 5 years-were invited to participate in spirometry and CPET...
December 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27279014/congenital-diaphragmatic-hernia-influence-of-fetoscopic-tracheal-occlusion-on-outcomes-and-predictors-of-survival
#2
Kamal Ali, Perraju Bendapudi, Satyamaanasa Polubothu, Gwendolyn Andradi, Mercy Ofuya, Janet Peacock, Ann Hickey, Mark Davenport, Kypros Nicolaides, Anne Greenough
UNLABELLED: The morbidity of infants with congenital diaphragmatic hernia (CDH) who had undergone foetal endoscopic tracheal occlusion (FETO) to those who had not was compared and predictors of survival regardless of antenatal intervention were identified. FETO was undertaken on the basis of the lung to head ratio or the position of the liver. A retrospective review of the records of 78 CDH infants was undertaken to determine the lung-head ratio (LHR) at referral and prior to birth, maximum oxygen saturation in the labour suite and neonatal outcomes...
August 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/26458370/survival-of-outborns-with-congenital-diaphragmatic-hernia-the-role-of-protective-ventilation-early-presentation-and-transport-distance-a-retrospective-cohort-study
#3
Katarina Bojanić, Ena Pritišanac, Tomislav Luetić, Jurica Vuković, Juraj Sprung, Toby N Weingarten, William A Carey, Darrell R Schroeder, Ruža Grizelj
BACKGROUND: Congenital diaphragmatic hernia (CDH) is a congenital malformation associated with life-threatening pulmonary dysfunction and high neonatal mortality. Outcomes are improved with protective ventilation, less severe pulmonary pathology, and the proximity of the treating center to the site of delivery. The major CDH treatment center in Croatia lacks a maternity ward, thus all CDH patients are transferred from local Zagreb hospitals or remote areas (outborns). In 2000 this center adopted protective ventilation for CDH management...
2015: BMC Pediatrics
https://www.readbyqxmd.com/read/27312047/lung-size-and-liver-herniation-predict-the-need-for-extra-corporeal-membrane-oxygenation-but-not-pulmonary-hypertension-in-isolated-congenital-diaphragmatic-hernia-a-systematic-review-and-meta-analysis
#4
Francesca Maria Russo, Mary Patrice Eastwood, Richard Keijzer, Jamila Al-Maary, Jaan Toelen, Tim Van Mieghem, Jan A Deprest
OBJECTIVES: To identify antenatal predictors of persistent pulmonary hypertension (PPH) and need for extracorporeal membrane oxygenation (ECMO) in fetuses with congenital diaphragmatic hernia (CDH). MATERIAL AND METHODS: We performed a systematic literature review of antenatal diagnostic tests in fetuses with isolated CDH. The target conditions were PPH within 28 days of life and the need for ECMO. Quality of studies was assessed with the QUADAS-2 tool. Meta-analysis was performed when at least three studies reported on the same test...
June 17, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27342009/right-versus-left-sided-congenital-diaphragmatic-hernia-a-comparative-outcomes-analysis
#5
Emily A Partridge, William H Peranteau, Lisa Herkert, Norma Rendon, Haylee Smith, Natalie E Rintoul, Alan W Flake, N Scott Adzick, Holly L Hedrick
PURPOSE: Right-sided congenital diaphragmatic hernia (R-CDH) occurs in up to 25% of all CDH cases, but has been less widely studied compared to left-sided defects. We sought to compare characteristics and outcomes of left- versus right-sided defects in a large cohort of CDH patients who underwent standardized treatment and follow-up at a single institution. METHODS: We retrospectively reviewed charts of all CDH patients in our pulmonary hypoplasia program from January 2002 through December 2014...
June 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27011107/antenatal-assessment-of-liver-position-rather-than-lung-to-head-ratio-lhr-or-observed-expected-lhr-is-predictive-of-outcome-in-fetuses-with-isolated-left-sided-congenital-diaphragmatic-hernia
#6
Zbyněk Straňák, Ladislav Krofta, Lucia Anna Haak, Jiří Vojtěch, Luboš Hašlík, Michal Rygl, Karel Pýcha, Jaroslav Feyereisl
OBJECTIVES: Respiratory morbidity in congenital diaphragmatic hernia (CDH) is associated with high mortality and adverse outcome. Accurate prenatal diagnosis is essential for prognosis and potential treatment in utero. The aim was to evaluate the prenatal ultrasound findings in assessing the respiratory prognosis in fetuses with isolated left-sided CDH. METHODS: We retrospectively analyzed the medical records of 59 prenatally diagnosed left-sided CDH cases managed at a tertiary perinatal center...
March 24, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27225962/management-of-pulmonary-hypertension-in-infants-with-congenital-diaphragmatic-hernia
#7
REVIEW
J Gien, J P Kinsella
In infants with congenital diaphragmatic hernia (CDH), a posterolateral diaphragmatic defect results in herniation of abdominal contents into the chest and compression of the intrathoracic structures. In the most severe cases, hypoplasia of the ipsilateral and contralateral lungs, severe pulmonary hypertension (PH) and left ventricular (LV) hypoplasia/dysfunction all contribute to increased mortality. The management of PH in CDH is complicated by structural and functional changes in the heart, pulmonary vasculature, airways and lung parenchyma; consequently, determining optimal management strategies is challenging...
June 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27077664/standardized-postnatal-management-of-infants-with-congenital-diaphragmatic-hernia-in-europe-the-cdh-euro-consortium-consensus-2015-update
#8
Kitty G Snoek, Irwin K M Reiss, Anne Greenough, Irma Capolupo, Berndt Urlesberger, Lucas Wessel, Laurent Storme, Jan Deprest, Thomas Schaible, Arno van Heijst, Dick Tibboel
In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, the number of participating centers has been raised from 13 to 22. In this article the relevant literature is updated, and consensus has been reached between the members of the CDH EURO Consortium. Key updated recommendations are: (1) planned delivery after a gestational age of 39 weeks in a high-volume tertiary center; (2) neuromuscular blocking agents to be avoided during initial treatment in the delivery room; (3) adapt treatment to reach a preductal saturation of between 80 and 95% and postductal saturation >70%; (4) target PaCO2 to be between 50 and 70 mm Hg; (5) conventional mechanical ventilation to be the optimal initial ventilation strategy, and (6) intravenous sildenafil to be considered in CDH patients with severe pulmonary hypertension...
2016: Neonatology
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