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A David Edwards, Maggie E Redshaw, Nigel Kennea, Oliver Rivero-Arias, Nuria Gonzales-Cinca, Phumza Nongena, Moegamad Ederies, Shona Falconer, Andrew Chew, Omar Omar, Pollyanna Hardy, Merryl Elizabeth Harvey, Oya Eddama, Naomi Hayward, Julia Wurie, Denis Azzopardi, Mary A Rutherford, Serena Counsell
BACKGROUND: We tested the hypothesis that routine MRI would improve the care and well-being of preterm infants and their families. DESIGN: Parallel-group randomised trial (1.1 allocation; intention-to-treat) with nested diagnostic and cost evaluations (EudraCT 2009-011602-42). SETTING: Participants from 14 London hospitals, imaged at a single centre. PATIENTS: 511 infants born before 33 weeks gestation underwent both MRI and ultrasound around term...
January 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Nansi S Boghossian, Scott A McDonald, Edward F Bell, Waldemar A Carlo, Jane E Brumbaugh, Barbara J Stoll, Abbot R Laptook, Seetha Shankaran, Michele C Walsh, Abhik Das, Rosemary D Higgins
IMPORTANCE: Little is known about the effects of antenatal corticosteroids (ANS) on extremely preterm multiples. OBJECTIVE: To examine if use of ANS is associated with improvement in major outcomes in extremely preterm multiples. DESIGN, SETTING, AND PARTICIPANTS: Infants with a gestational age between 22 and 28 weeks born at a National Institute of Child Health and Human Development Neonatal Research Network center were studied between January 1998 and December 2013...
June 1, 2016: JAMA Pediatrics
S J Steggerda, G van Wezel-Meijler
Cranial ultrasonography (CUS) is a reliable and non-invasive tool to detect frequently occurring brain abnormalities and to monitor brain development and maturation in high risk neonates. Standard CUS views are obtained through the anterior fontanel. However, evaluation of the posterior fossa is often suboptimal with this approach. Cerebellar injury occurs frequently in preterm infants and has important prognostic consequences. Early detection is therefore important. This review focuses on techniques that optimize the performance of CUS when studying the preterm cerebellum, including the use of the mastoid fontanel and the adaptation of focus points and scan frequencies...
October 2016: Seminars in Fetal & Neonatal Medicine
Seung Han Shin, Ee-Kyung Kim, Hani Yoo, Young Hun Choi, Saeyun Kim, Byoung Kook Lee, Young Hwa Jung, Hyun-Young Kim, Han-Suk Kim, Jung-Hwan Choi
BACKGROUND: White matter injury (WMI) is the most common form of brain injury in preterm infants. It could be induced by a systemic inflammatory response in preterm infants. OBJECTIVES: We hypothesized that surgical necrotizing enterocolitis (surgNEC) results in more severe WMI than spontaneous intestinal perforation (SIP) on brain magnetic resonance imaging (MRI) at term-equivalent age (TEA). METHODS: The medical records of 33 preterm infants born at less than 32 weeks of gestation who underwent surgery due to either NEC or SIP were reviewed retrospectively...
2016: Neonatology
Mariya Malova, Andrea Rossi, Mariasavina Severino, Alessandro Parodi, Giovanni Morana, Andrea Sannia, Armando Cama, Luca Antonio Ramenghi
OBJECTIVE: Many neonatal intensive care units (NICUs) have adopted the practice of performing routine brain MRI in very low birth weight (VLBW) infants at term-equivalent age in order to better evaluate prematurity-related acquired lesions. A number of unexpected brain abnormalities of potential clinical significance can be visualised on routine scans as well. The aim of our study was to describe these incidental findings (IFs) in a VLBW population and to assess their clinical significance...
January 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
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