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Depression and mood disorders

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8 papers 25 to 100 followers
Albino J Oliveira-Maia, Ana-Lucia Garcia-Guarniz, Antigoni Sinanis, Alvaro Pascual-Leone, Daniel Press
No abstract text is available yet for this article.
June 2016: Journal of Clinical Psychiatry
Barbara Milrod
No abstract text is available yet for this article.
May 2016: Journal of Clinical Psychiatry
Brisa S Fernandes, Olivia M Dean, Seetal Dodd, Gin S Malhi, Michael Berk
OBJECTIVE: To assess the utility of N-acetylcysteine administration for depressive symptoms in subjects with psychiatric conditions using a systematic review and meta-analysis. DATA SOURCES: A computerized literature search was conducted in MEDLINE, Embase, the Cochrane Library, SciELO, PsycINFO, Scopus, and Web of Knowledge. No year or country restrictions were used. The Boolean terms used for the electronic database search were (NAC OR N-acetylcysteine OR acetylcysteine) AND (depression OR depressive OR depressed) AND (trial)...
April 2016: Journal of Clinical Psychiatry
Zhen Ren, Horia Pribiag, Sarah J Jefferson, Matthew Shorey, Thomas Fuchs, David Stellwagen, Bernhard Luscher
BACKGROUND: Major depressive disorder is increasingly recognized to involve functional deficits in both gamma-aminobutyric acid (GABA)ergic and glutamatergic synaptic transmission. To elucidate the relationship between these phenotypes, we used GABAA receptor γ2 subunit heterozygous (γ2(+/-)) mice, which we previously characterized as a model animal with construct, face, and predictive validity for major depressive disorder. METHODS: To assess possible consequences of GABAergic deficits on glutamatergic transmission, we quantitated the cell surface expression of N-methyl-D-aspartate (NMDA)-type and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors and the function of synapses in the hippocampus and medial prefrontal cortex of γ2(+/-) mice...
September 15, 2016: Biological Psychiatry
Jerome Sarris, Jenifer Murphy, David Mischoulon, George I Papakostas, Maurizio Fava, Michael Berk, Chee H Ng
OBJECTIVE: There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants. The adjunctive use of standardized pharmaceutical-grade nutrients, known as nutraceuticals, has the potential to modulate several neurochemical pathways implicated in depression. While many studies have been conducted in this area, to date no specialized systematic review (or meta-analysis) has been conducted. METHOD: A systematic search of PubMed, CINAHL, Cochrane Library, and Web of Science was conducted up to December 2015 for clinical trials using adjunctive nutrients for depression...
June 1, 2016: American Journal of Psychiatry
Ross Balchin, Jani Linde, Dee Blackhurst, Hg Laurie Rauch, Georg Schönbächler
BACKGROUND: In periods of prolonged stress and pain the body produces endorphins to help endure pain. The PANIC system is built on the same pathways as the pain system and is characterized by behaviour that looks like depression. The term 'mental pain' in the context of feelings of loss is arguably justified in light of this relationship between the physical pain and social loss systems. It is reasonable to expect that endorphin release ameliorates depression. METHODS: Moderately depressed males (n=30) were randomly assigned to one of three groups of varying exercise intensity...
August 2016: Journal of Affective Disorders
Ruin Moaddel, David A Luckenbaugh, Ying Xie, Alma Villaseñor, Nancy E Brutsche, Rodrigo Machado-Vieira, Anuradha Ramamoorthy, Maria Paz Lorenzo, Antonia Garcia, Michel Bernier, Marc C Torjman, Coral Barbas, Carlos A Zarate, Irving W Wainer
RATIONALE: (R,S)-ketamine is a rapid and effective antidepressant drug that produces a response in two thirds of patients with treatment-resistant depression (TRD). The underlying biochemical differences between a (R,S)-ketamine responder (KET-R) and non-responder (KET-NR) have not been definitively identified but may involve serine metabolism. OBJECTIVES: The aim of the study was to examine the relationship between baseline plasma concentrations of D-serine and its precursor L-serine and antidepressant response to (R,S)-ketamine in TRD patients...
January 2015: Psychopharmacology
A F Jorm, H Christensen, J Medway, A E Korten, P A Jacomb, B Rodgers
BACKGROUND: Previous research has found that there are major differences between public and professional beliefs about the helpfulness of interventions for depression. The public appear to be guided by general belief systems about the helpfulness of medical, psychological and lifestyle interventions rather than by specific knowledge about what interventions are effective for depression. The present paper examines the effect that experiencing depression and receiving treatment might have on these beliefs...
May 2000: Social Psychiatry and Psychiatric Epidemiology
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