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Prevention

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8 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27616593/interpretation-of-the-evidence-for-the-efficacy-and-safety-of-statin-therapy
#1
Rory Collins, Christina Reith, Jonathan Emberson, Jane Armitage, Colin Baigent, Lisa Blackwell, Roger Blumenthal, John Danesh, George Davey Smith, David DeMets, Stephen Evans, Malcolm Law, Stephen MacMahon, Seth Martin, Bruce Neal, Neil Poulter, David Preiss, Paul Ridker, Ian Roberts, Anthony Rodgers, Peter Sandercock, Kenneth Schulz, Peter Sever, John Simes, Liam Smeeth, Nicholas Wald, Salim Yusuf, Richard Peto
This Review is intended to help clinicians, patients, and the public make informed decisions about statin therapy for the prevention of heart attacks and strokes. It explains how the evidence that is available from randomised controlled trials yields reliable information about both the efficacy and safety of statin therapy. In addition, it discusses how claims that statins commonly cause adverse effects reflect a failure to recognise the limitations of other sources of evidence about the effects of treatment...
September 8, 2016: Lancet
https://www.readbyqxmd.com/read/27548766/efficacy-of-folic-acid-therapy-on-the-progression-of-chronic-kidney-disease-the-renal-substudy-of-the-china-stroke-primary-prevention-trial
#2
Xin Xu, Xianhui Qin, Youbao Li, Danhua Sun, Jun Wang, Min Liang, Binyan Wang, Yong Huo, Fan Fan Hou
Importance: The efficacy of folic acid therapy on renal outcomes has not been previously investigated in populations without folic acid fortification. Objective: To test whether treatment with enalapril and folic acid is more effective in slowing renal function decline than enalapril alone across a spectrum of renal function at baseline from normal to moderate chronic kidney disease (CKD) among Chinese adults with hypertension. Design, Setting, and Participants: In this substudy of eligible China Stroke Primary Prevention Trial (CSPPT), 15 104 participants with an estimated glomerular filtration rate (eGFR) 30 mL/min/1...
October 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27183456/how-patent-troll-legislation-can-increase-timely-access-to-generic-drugs
#3
Carolyn L Treasure, Aaron S Kesselheim
No abstract text is available yet for this article.
June 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27127637/risk-factors-and-therapeutic-coverage-at-6%C3%A2-years-in-patients-with-previous-myocardial-infarction-the-castuo-study
#4
Francisco Javier Félix-Redondo, Luis Lozano Mera, Luciano Consuegra-Sánchez, Fernando Giménez Sáez, Francisco Javier Garcipérez de Vargas, José María Castellano Vázquez, Daniel Fernández-Bergés
OBJECTIVES: To determine the degree of risk factor control, the clinical symptoms and the therapeutic management of patients with a history of previous myocardial infarction. METHODS: Cross-sectional study at 6 years of a first episode of acute myocardial infarction between 2000 and 2009, admitted at a hospital in the region of Extremadura (Spain). Of 2177 patients with this diagnosis, 1365 remained alive and therefore were included in the study. RESULTS: We conducted a person-to-person survey in 666 (48...
2016: Open Heart
https://www.readbyqxmd.com/read/27040132/cholesterol-lowering-in-intermediate-risk-persons-without-cardiovascular-disease
#5
RANDOMIZED CONTROLLED TRIAL
Salim Yusuf, Jackie Bosch, Gilles Dagenais, Jun Zhu, Denis Xavier, Lisheng Liu, Prem Pais, Patricio López-Jaramillo, Lawrence A Leiter, Antonio Dans, Alvaro Avezum, Leopoldo S Piegas, Alexander Parkhomenko, Katalin Keltai, Matyas Keltai, Karen Sliwa, Ron J G Peters, Claes Held, Irina Chazova, Khalid Yusoff, Basil S Lewis, Petr Jansky, Kamlesh Khunti, William D Toff, Christopher M Reid, John Varigos, Gregorio Sanchez-Vallejo, Robert McKelvie, Janice Pogue, Hyejung Jung, Peggy Gao, Rafael Diaz, Eva Lonn
BACKGROUND: Previous trials have shown that the use of statins to lower cholesterol reduces the risk of cardiovascular events among persons without cardiovascular disease. Those trials have involved persons with elevated lipid levels or inflammatory markers and involved mainly white persons. It is unclear whether the benefits of statins can be extended to an intermediate-risk, ethnically diverse population without cardiovascular disease. METHODS: In one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants in 21 countries who did not have cardiovascular disease and were at intermediate risk to receive rosuvastatin at a dose of 10 mg per day or placebo...
May 26, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27143685/2016-focused-update-clinical-recommendations-for-cardiopulmonary-exercise-testing-data-assessment-in-specific-patient-populations
#6
Marco Guazzi, Ross Arena, Martin Halle, Massimo F Piepoli, Jonathan Myers, Carl J Lavie
In the past several decades, cardiopulmonary exercise testing (CPX) has seen an exponential increase in its evidence base. The growing volume of evidence in support of CPX has precipitated the release of numerous scientific statements by societies and associations. In 2012, the European Association for Cardiovascular Prevention & Rehabilitation and the American Heart Association developed a joint document with the primary intent of redefining CPX analysis and reporting in a way that would streamline test interpretation and increase clinical application...
June 14, 2016: Circulation
https://www.readbyqxmd.com/read/27081117/high-density-lipoprotein-proteomic-composition-and-not-efflux-capacity-reflects-differential-modulation-of-reverse-cholesterol-transport-by-saturated-and-monounsaturated-fat-diets
#7
Marcella O'Reilly, Eugene Dillon, Weili Guo, Orla Finucane, Aoibheann McMorrow, Aoife Murphy, Claire Lyons, Daniel Jones, Miriam Ryan, Michael Gibney, Eileen Gibney, Lorraine Brennan, Margarita de la Llera Moya, Muredach P Reilly, Helen M Roche, Fiona C McGillicuddy
BACKGROUND: Acute inflammation impairs reverse cholesterol transport (RCT) and reduces high-density lipoprotein (HDL) function in vivo. This study hypothesized that obesity-induced inflammation impedes RCT and alters HDL composition, and investigated if dietary replacement of saturated (SFA) for monounsaturated (MUFA) fatty acids modulates RCT. METHODS AND RESULTS: Macrophage-to-feces RCT, HDL efflux capacity, and HDL proteomic profiling was determined in C57BL/6j mice following 24 weeks on SFA- or MUFA-enriched high-fat diets (HFDs) or low-fat diet...
May 10, 2016: Circulation
https://www.readbyqxmd.com/read/27039945/blood-pressure-and-cholesterol-lowering-in-persons-without-cardiovascular-disease
#8
RANDOMIZED CONTROLLED TRIAL
Salim Yusuf, Eva Lonn, Prem Pais, Jackie Bosch, Patricio López-Jaramillo, Jun Zhu, Denis Xavier, Alvaro Avezum, Lawrence A Leiter, Leopoldo S Piegas, Alexander Parkhomenko, Matyas Keltai, Katalin Keltai, Karen Sliwa, Irina Chazova, Ron J G Peters, Claes Held, Khalid Yusoff, Basil S Lewis, Petr Jansky, Kamlesh Khunti, William D Toff, Christopher M Reid, John Varigos, Jose L Accini, Robert McKelvie, Janice Pogue, Hyejung Jung, Lisheng Liu, Rafael Diaz, Antonio Dans, Gilles Dagenais
BACKGROUND: Elevated blood pressure and elevated low-density lipoprotein (LDL) cholesterol increase the risk of cardiovascular disease. Lowering both should reduce the risk of cardiovascular events substantially. METHODS: In a trial with 2-by-2 factorial design, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to rosuvastatin (10 mg per day) or placebo and to candesartan (16 mg per day) plus hydrochlorothiazide (12...
May 26, 2016: New England Journal of Medicine
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