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By Wei No
https://www.readbyqxmd.com/read/28062405/presence-of-multiple-spondyloarthritis-spa-features-is-important-but-not-sufficient-for-a-diagnosis-of-axial-spondyloarthritis-data-from-the-spondyloarthritis-caught-early-space-cohort
#1
Z Ez-Zaitouni, P A C Bakker, M van Lunteren, I J Berg, R Landewé, M van Oosterhout, M Lorenzin, D van der Heijde, F A van Gaalen
OBJECTIVES: Concerns have been raised about overdiagnosis of axial spondyloarthritis (axSpA). We investigated whether patients with chronic back pain (CBP) of short duration and multiple SpA features are always diagnosed with axSpA by the rheumatologist, and to what extent fulfilment of the Assessment of SpondyloArthritis International Society (ASAS) axSpA criteria is associated with an axSpA diagnosis. METHODS: Baseline data from 500 patients from the SPondyloArthritis Caught Early cohort which includes patients with CBP (≥3 months, ≤2 years, onset <45 years) were analysed...
January 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28100423/osteoarthritis-year-in-review-2016-clinical
#2
REVIEW
N E Lane, K Shidara, B L Wise
Both epidemiologic and clinical research continues to be performed in osteoarthritis (OA). While epidemiologic studies identify risk factors for incident and progressive disease, clinical studies explore the role of both non-pharmacologic and pharmacologic treatments, including oral and intra-articular therapies. We performed a systematic review of the literature using PubMed for the time period between April 1, 2015 to February 22, 2016. Selected publications in the areas of both epidemiology and treatment are reviewed in this article...
December 20, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27988431/clinical-utility-of-circulating-anti-n-methyl-d-aspartate-receptor-subunits-nr2a-b-antibody-for-the-diagnosis-of-neuropsychiatric-syndromes-in-systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome-an-updated-meta-analysis
#3
REVIEW
Sen Hee Tay, Anna-Marie Fairhurst, Anselm Mak
BACKGROUND/PURPOSE: Neuropsychiatric (NP) events are found in patients with rheumatic diseases, commonly in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). The standard nomenclature and case definitions for 19 NPSLE syndromes by the American College of Rheumatology (ACR) Committee on Research cover a wide range of NP events seen in both SLE and SS. Despite advances in the understanding of SLE and SS, NP syndromes continue to pose diagnostic challenges. Correct attribution of NP events is critical in determining the correct treatment and prognosis...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28079512/long-term-treatment-response-in-rheumatoid-arthritis-patients-starting-adalimumab-or-etanercept-with-or-without-concomitant-methotrexate
#4
Merel J l'Ami, Eva L Kneepkens, Michael T Nurmohamed, Charlotte L M Krieckaert, Ingrid M Visman, Gert-Jan Wolbink
OBJECTIVES: To observe long-term clinical response and drug survival in a prospective two-year cohort study in rheumatoid arthritis (RA) patients starting adalimumab or etanercept treatment, with or without methotrexate (MTX), after failure of conventional DMARD therapy, including MTX. METHODS: Disease activity score of 28 joints (DAS28) and Health Assessment Questionnaire (HAQ) were collected of 873 consecutive RA patients, treated with adalimumab or etanercept, prospectively at baseline, 4, 16, 28, 40, 52, 78 and 104 weeks of biological therapy...
January 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28077865/systemic-sclerosis-in-2016-dermal-white-adipose-tissue-implicated-in-ssc-pathogenesis
#5
John Varga, Roberta G Marangoni
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28077868/rheumatoid-arthritis-tak-ing-the-road-to-suppress-inflammation-in-synovial-fibroblasts
#6
Mojca Frank-Bertoncelj, Steffen Gay
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28077867/microbiome-in-2016-t-follicular-helper-cells-and-the-gut-microbiome-in-arthritis
#7
Veena Taneja
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28063071/interstitial-lung-disease-in-systemic-sclerosis-current-and-future-treatment
#8
REVIEW
Roberto Giacomelli, Vasiliki Liakouli, Onorina Berardicurti, Piero Ruscitti, Paola Di Benedetto, Francesco Carubbi, Giuliana Guggino, Salvatore Di Bartolomeo, Francesco Ciccia, Giovanni Triolo, Paola Cipriani
Systemic sclerosis (SSc) has the highest fatality rate among connective tissue diseases and is characterized by vascular damage, inflammation and fibrosis of the skin and various internal organs. Interstitial lung disease (ILD) frequently complicates SSc and can be a debilitating disorder with a poor prognosis. ILD is the most frequent cause of death in SSc, and the management of SSc-ILD patients is a great challenge. Early detection of pulmonary involvement based on a recent decline of lung function tests and on the extent of lung involvement at high-resolution computed tomography is critical for the best management of these patients...
January 6, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28077693/new-grappa-and-eular-recommendations-for-the-management-of-psoriatic-arthritis-process-and-challenges-faced
#9
EDITORIAL
Laura C Coates, Laure Gossec, Sofia Ramiro, Philip Mease, Désirée van der Heijde, Josef S Smolen, Christopher Ritchlin, Arthur Kavanaugh
No abstract text is available yet for this article.
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/27027812/suppression-of-normal-immune-responses-after-treatment-with-rituximab
#10
REVIEW
Ruba Kado, Georgiana Sanders, W Joseph McCune
PURPOSE OF REVIEW: Because rituximab is increasingly used in systemic autoimmune diseases, alone or in combination with other immunosuppressive medication, secondary reduction of normal immune defenses has become a more significant clinical problem. RECENT FINDINGS: The goal of rituximab treatment of immune-mediated conditions is complete depletion of circulating B cells. Studies have suggested that lack of complete B-cell depletion is associated with nonresponse, and B-cell repletion can predict relapse...
May 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27988437/sj%C3%A3-gren-s-syndrome-associated-myositis-with-germinal-centre-like-structures
#11
REVIEW
Alexandra Espitia-Thibault, Agathe Masseau, Antoine Néel, Olivier Espitia, Claire Toquet, Jean-Marie Mussini, Mohamed Hamidou
OBJECTIVE: Muscular impairment is a rare systemic manifestation of SS that is rarely described in the literature and classically non-specific, both clinically and histologically. We reviewed the cases of 4 patients with primary SS presenting with myositis and a common histologic pattern on muscular biopsy with germinal centre-like structures resembling that which occurs in salivary glands. METHODS: We analysed the data files of patients with SS who had muscular manifestations and underwent a muscular biopsy...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27989011/temporomandibular-joint-findings-in-patients-with-rheumatoid-arthritis-ankylosing-spondylitis-and-primary-sj%C3%A3-gren-s-syndrome
#12
Elif Yıldızer Keriş, Sis Darendeliler Yaman, Mehmet Derya Demirağ, Şeminur Haznedaroğlu
AIM: The aim of the present study was to investigate the prevalence of temporomandibular joint (TMJ) symptoms in rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), and ankylosing spondylitis (AS) patients. METHODS: The present study consisted of 79 individuals with various rheumatic disease (study group: 39 with RA, 17 with AS, 23 with pSS) and 79 age- and sex-matched healthy controls (control group). Subjective symptoms of the TMJ were recorded by means of a questionnaire...
December 17, 2016: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/27992404/a-gene-network-regulated-by-the-transcription-factor-vgll3-as-a-promoter-of-sex-biased-autoimmune-diseases
#13
Yun Liang, Lam C Tsoi, Xianying Xing, Maria A Beamer, William R Swindell, Mrinal K Sarkar, Celine C Berthier, Philip E Stuart, Paul W Harms, Rajan P Nair, James T Elder, John J Voorhees, J Michelle Kahlenberg, Johann E Gudjonsson
Autoimmune diseases affect 7.5% of the US population, and they are among the leading causes of death and disability. A notable feature of many autoimmune diseases is their greater prevalence in females than in males, but the underlying mechanisms of this have remained unclear. Through the use of high-resolution global transcriptome analyses, we demonstrated a female-biased molecular signature associated with susceptibility to autoimmune disease and linked this to extensive sex-dependent co-expression networks...
February 2017: Nature Immunology
https://www.readbyqxmd.com/read/27992710/subjective-and-objective-measures-of-dryness-symptoms-in-primary-sj%C3%A3-gren-s-syndrome-capturing-the-discrepancy
#14
Oriana M Bezzina, Peter Gallagher, Sheryl Mitchell, Simon J Bowman, Bridget Griffiths, Victoria Hindmarsh, Ben Hargreaves, Elizabeth J Price, Colin T Pease, Paul Emery, Peter Lanyon, Michele Bombardieri, Nurhan Sutcliffe, Costantino Pitzalis, John Hunter, Monica Gupta, John McLaren, Anne M Cooper, Marian Regan, Ian P Giles, David A Isenberg, Saravanan Vadivelu, David Coady, Bhaskar Dasgupta, Neil J McHugh, Steven A Young-Min, Robert J Moots, Nagui Gendi, Mohammed Akil, Kirsten MacKay, W Fai Ng, Lucy J Robinson
BACKGROUND: There is a weak relationship between subjective symptoms and objective markers of disease activity in individuals with Primary Sjögren's Syndrome (PSS). This presents a significant barrier to developing treatments if modifying disease markers does not translate into reduced perception of symptoms. Little is known about the reasons for this discrepancy. OBJECTIVES: To develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a 'Sensitivity' scale) and to explore predictors of dryness Sensitivity...
December 19, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27994222/connective-tissue-diseases-refining-the-classification-criteria-for-primary-sj%C3%A3-gren-syndrome
#15
Arjan Vissink, Hendrika Bootsma
No abstract text is available yet for this article.
December 20, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28067896/pathogenic-role-of-endogenous-tnf-%C3%AE-in-the-development-of-sj%C3%A3-gren-s-like-sialadenitis-and-secretory-dysfunction-in-non-obese-diabetic-mice
#16
Jing Zhou, Toshihisa Kawai, Qing Yu
Patients with Sjögren's syndrome (SS), an autoimmune disease primarily affecting exocrine glands, exhibit enhanced TNF-α expression in the saliva and salivary glands. However, the precise in vivo role of TNF-α during the initiation and development of SS is not clearly defined. The present study is undertaken to determine the function of endogenously produced TNF-α in the pathogenesis of SS in non-obese diabetic (NOD) mice, a model of this human disease. Administration of a neutralizing anti-TNF-α antibody to female NOD mice during the stage prior to disease onset significantly improved salivary secretion, indicating a remission of clinical symptoms of SS...
January 9, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/26979603/clinical-features-and-long-term-outcomes-of-systemic-lupus-erythematosus-comparative-data-of-childhood-adult-and-late-onset-disease-in-a-national-register
#17
S Sousa, M J Gonçalves, L S Inês, G Eugénio, D Jesus, S Fernandes, G Terroso, V C Romão, M Cerqueira, A Raposo, M Couto, P Nero, G Sequeira, T Nóvoa, J A Melo Gomes, J Canas da Silva, L Costa, C Macieira, C Silva, J A P Silva, H Canhão, M J Santos
Systemic lupus erythematosus (SLE) affects predominantly women at reproductive age but may present at any age. Age at disease onset has a modulating effect on presentation and course of disease, but controversies persist regarding its impact on long-term outcome. Our aims were to characterize clinical features, co-morbidities and cumulative damage in childhood-onset, adult-onset and late-onset SLE. Patients with childhood-onset SLE fulfilling ACR 1997 criteria were identified in a nationwide register-Reuma...
July 2016: Rheumatology International
https://www.readbyqxmd.com/read/28039187/initial-combination-therapy-with-ambrisentan-and-tadalafil-in-connective-tissue-disease-associated-pulmonary-arterial-hypertension-ctd-pah-subgroup-analysis-from-the-ambition-trial
#18
John Gerry Coghlan, Nazzareno Galiè, Joan Albert Barberà, Adaani E Frost, Hossein-Ardeschir Ghofrani, Marius M Hoeper, Masataka Kuwana, Vallerie V McLaughlin, Andrew J Peacock, Gérald Simonneau, Jean-Luc Vachiéry, Christiana Blair, Hunter Gillies, Karen L Miller, Julia H N Harris, Jonathan Langley, Lewis J Rubin
BACKGROUND: Patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH), in particular systemic sclerosis (SSc), had an attenuated response compared with idiopathic PAH in most trials. Thus, there is uncertainty regarding the benefit of PAH-targeted therapy in some forms of CTD-PAH. OBJECTIVE: To explore the safety and efficacy of initial combination therapy with ambrisentan and tadalafil versus ambrisentan or tadalafil monotherapy in patients with CTD-PAH and SSc-PAH enrolled in the AMBITION trial...
December 30, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28042126/b-cell-depletion-therapy-normalizes-circulating-follicular-th-cells-in-primary-sj%C3%A3-gren-syndrome
#19
Gwenny M Verstappen, Frans G M Kroese, Petra M Meiners, Odilia B Corneth, Minke G Huitema, Erlin A Haacke, Bert van der Vegt, Suzanne Arends, Arjan Vissink, Hendrika Bootsma, Wayel H Abdulahad
OBJECTIVE: To assess the effect of B cell depletion therapy on effector CD4+ T cell homeostasis and its relation to objective measures of disease activity in patients with primary Sjögren syndrome (pSS). METHODS: Twenty-four patients with pSS treated with rituximab (RTX) and 24 healthy controls (HC) were included. Frequencies of circulating effector CD4+ T cell subsets were examined by flow cytometry at baseline and 16, 24, 36, and 48 weeks after the first RTX infusion...
January 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28049394/coexistence-of-amyloidosis-and-primary-sj%C3%A3-gren-s-syndrome-an-overview-amyloidosis-and-sj%C3%A3-gren-s-syndrome
#20
Gabriela Hernandez-Molina, David Faz-Muñoz, Miguel Astudillo-Angel, Alejandra Iturralde-Chávez, Edgardo Reyes
BACKGROUND: The association of primary Sjögren´s syndrome (SS) and amyloidosis has been recognized but scarcely assessed. OBJECTIVE: Herein we analyzed the literature regarding this association in order to describe a SS phenotype prone to both conditions. METHODS: PubMed and CINAHL databases were searched from inception until April 2016 for the key words: amyloidosis, amyloid, Sjögren's syndrome and their combinations. RESULTS: Most of the cases corresponded to localized amyloidosis mainly at skin and lung, whereas only three cases were systemic...
January 3, 2017: Current Rheumatology Reviews
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