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By Wei No
https://www.readbyqxmd.com/read/29028676/air-pollution-as-a-potential-determinant-of-rheumatoid-arthritis-a-population-based-cohort-study-in-taiwan
#1
Chau-Ren Jung, Hui-Ya Hsieh, Bing-Fang Hwang
BACKGROUND: Limited studies have explored the relationship between air pollution and rheumatoid arthritis (RA), with the results being somewhat inconsistent. METHODS: This was a retrospective cohort study that included 322,301 subjects aged 30-50 years, selected from the National Health Insurance Research Database in Taiwan, were followed from 2001 to 2010. We used a time-dependent extended Cox model and incorporated time-dependent variables to estimate the associations between the annual mean concentrations of air pollutants with RA, including carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), particles with an aerodynamic diameter less than 10 μm (PM10), and sulfur dioxide (SO2), and reported the hazard ratio (HR) and 95% confidence interval (CI)...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29029308/difficult-to-treat-rheumatoid-arthritis-an-area-of-unmet-clinical-need
#2
Maria J H de Hair, Johannes W G Jacobs, Jan L M Schoneveld, Jacob M van Laar
Increased effectiveness of pharmacological treatments in early RA has led many to believe that difficult-to-treat, established RA is a condition of the past. However, there are still plenty of RA patients who continue to have signs and symptoms suggestive of inflammatory disease activity, despite consecutive treatment with multiple conventional synthetic and biological DMARDs. We argue that difficult-to-treat RA constitutes an area of unmet clinical need and propose a definition of this concept. An overview of what is known about the multiple contributory factors varying for each individual patient, and an approach towards improved patient-tailored management are presented...
October 4, 2017: Rheumatology
https://www.readbyqxmd.com/read/28698947/the-effect-of-cryotherapy-on-total-antioxidative-capacity-in-patients-with-active-seropositive-rheumatoid-arthritis
#3
H Hirvonen, H Kautiainen, E Moilanen, M Mikkelsson, M Leirisalo-Repo
Patients with rheumatoid arthritis (RA) have increased oxidative stress, decreased antioxidant levels, and impaired antioxidant capacity. Cold treatments are used to relieve joint inflammation and pain. Therefore, we measured the effect of cold treatments on the antioxidative capacity of RA patients with active disease. Sixty patients were randomized to (1) whole body cryotherapy at -110 °C, (2) whole body cryotherapy at -60 °C, or (3) local cryotherapy. Each treatment was given three times daily for 7 consecutive days in addition to the conventional rehabilitation...
July 11, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28585373/2017-american-college-of-rheumatology-guideline-for-the-prevention-and-treatment-of-glucocorticoid-induced-osteoporosis
#4
REVIEW
Lenore Buckley, Gordon Guyatt, Howard A Fink, Michael Cannon, Jennifer Grossman, Karen E Hansen, Mary Beth Humphrey, Nancy E Lane, Marina Magrey, Marc Miller, Lake Morrison, Madhumathi Rao, Angela Byun Robinson, Sumona Saha, Susan Wolver, Raveendhara R Bannuru, Elizaveta Vaysbrot, Mikala Osani, Marat Turgunbaev, Amy S Miller, Timothy McAlindon
OBJECTIVE: To develop recommendations for prevention and treatment of glucocorticoid-induced osteoporosis (GIOP). METHODS: We conducted a systematic review to synthesize the evidence for the benefits and harms of GIOP prevention and treatment options. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to rate the quality of evidence. We used a group consensus process to determine the final recommendations and grade their strength...
August 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28450312/long-term-outcome-is-better-when-a-methotrexate-based-treatment-strategy-is-combined-with-10-mg-prednisone-daily-follow-up-after-the-second-computer-assisted-management-in-early-rheumatoid-arthritis-trial
#5
M Safy, Jwg Jacobs, N D IJff, Jwj Bijlsma, J M van Laar, Mjh de Hair
OBJECTIVES: In the second Computer-Assisted Management in Early Rheumatoid Arthritis trial, patients had started with methotrexate and 10 mg prednisone (MTX+pred) or placebo (MTX+plac). After the trial, prednisone was tapered and stopped, if possible. The objective was to compare, during the post-trial follow-up between the two former strategy groups, initiation of the first biological disease-modifying antirheumatic drug (bDMARD), radiographic outcome and onset of glucocorticoid (GC)-related comorbidities...
August 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28432050/prevalence-of-remission-and-its-effect-on-damage-and-quality-of-life-in-chinese-patients-with-systemic-lupus-erythematosus
#6
Chi Chiu Mok, Ling Yin Ho, Sau Mei Tse, Kar Li Chan
OBJECTIVES: To study the prevalence of remission and its effect on damage and quality of life (QOL) in Chinese patients with systemic lupus erythematosus (SLE). METHODS: Patients who fulfilled ≥4 American College of Rheumatology criteria for SLE were identified. Their remission status at last clinic visits was determined by the European consensus criteria (complete/clinical remission ± immunosuppressive drugs). The increase in SLE damage index (SDI) in the preceding 5 years was compared between patients who were and were not in remission for ≥5 years...
August 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28416517/sua-levels-should-not-be-maintained-3-mg-dl-for-several-years-response-to-eular-gout-treatment-guidelines-by-richette-et-al-uric-acid-and-neurocognition-by-singh-et-al
#7
Pascal Richette, Michael Doherty, Eliseo Pascual, Thomas Bardin
No abstract text is available yet for this article.
April 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28457197/management-of-cardiovascular-risk-in-systemic-lupus-erythematosus-a-systematic-review
#8
C Andrades, C Fuego, S Manrique-Arija, A Fernández-Nebro
Systemic lupus erythematosus is associated with accelerated atherosclerosis and increased risk of cardiovascular complications. The aim of this study was to review the effectiveness of interventions for primary and secondary prevention of cardiovascular events and mortality and to review the effectiveness of interventions for cardiovascular risk factor reduction in systemic lupus erythematosus patients. A systematic review was conducted. Electronic databases Medline and Embase (1961-2015) were searched. Nineteen articles met the inclusion criteria and were selected...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28379387/a-new-mhc-linked-susceptibility-locus-for-primary-sj%C3%A3-gren-s-syndrome-mica
#9
Raphael Carapito, Jacques-Eric Gottenberg, Irina Kotova, Meiggie Untrau, Sandra Michel, Lydie Naegely, Ismail Aouadi, Marius Kwemou, Nicodème Paul, Angélique Pichot, James Locke, Simon J Bowman, Bridget Griffiths, Kathy L Sivils, Jean Sibilia, Hidetoshi Inoko, Corinne Micelli-Richard, Gaétane Nocturne, Masao Ota, Wan-Fai Ng, Xavier Mariette, Seiamak Bahram
The association of primary Sjögren's syndrome (pSS) with Major Histocompatibility Complex (MHC) alleles is quintessential of MHC-disease associations. Indeed, although disease associations with classical HLA class I and II alleles/haplotypes are amply documented, further dissection is often prevented by the strong linkage disequilibrium across the entire MHC complex. Here we study the association of pSS, not with HLA genes, but with the non-conventional MHC encoded class I gene, MICA (MHC class I chain-related gene A)...
July 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28330998/comparison-of-performance-of-the-2016-acr-eular-classification-criteria-for-primary-sj%C3%A3-gren-s-syndrome-with-other-sets-of-criteria-in-japanese-patients
#10
Hiroto Tsuboi, Shinya Hagiwara, Hiromitsu Asashima, Hiroyuki Takahashi, Tomoya Hirota, Hisashi Noma, Hisanori Umehara, Atsushi Kawakami, Hideki Nakamura, Hajime Sano, Kazuo Tsubota, Yoko Ogawa, Etsuko Takamura, Ichiro Saito, Hiroko Inoue, Seiji Nakamura, Masafumi Moriyama, Tsutomu Takeuchi, Yoshiya Tanaka, Shintaro Hirata, Tsuneyo Mimori, Isao Matsumoto, Takayuki Sumida
OBJECTIVES: To compare the performance of the new 2016 American College of Rheumatology (ACR)-European League Against Rheumatism (EULAR) classification criteria for primary Sjögren's syndrome (SS) with 1999 revised Japanese Ministry of Health criteria for diagnosis of SS (JPN), 2002 American-European Consensus Group classification criteria for SS (AECG) and 2012 ACR classification criteria for SS (ACR) in Japanese patients. METHODS: The study subjects were 499 patients with primary SS (pSS) or suspected pSS who were followed up in June 2012 at 10 hospitals in Japan...
March 22, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28339366/jaccoud-s-arthropathy-in-systemic-lupus-erythematosus-clinical-laboratory-and-ultrasonographic-features
#11
Fulvia Ceccarelli, Laura Massaro, Carlo Perricone, Monica Pendolino, Enrica Cipriano, Simona Truglia, Francesca Miranda, Francesca Romana Spinelli, Cristiano Alessandri, Guido Valesini, Fabrizio Conti
OBJECTIVES: Jaccoud's arthropathy (JA) is a deforming, non-erosive arthritis, occurring in 2-35% of systemic lupus erythematosus (SLE) patients. We aimed to evaluate JA patients in a wide monocentric SLE cohort in terms of clinical, serological and ultrasonographic features. METHODS: Consecutive SLE patients (ACR criteria 1997) were evaluated. The JA index was applied for patients with reducible deformities. Patients with a JA index ≥5 underwent physical examination, blood testing and ultrasound (US) assessment...
July 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28298559/the-risk-of-deep-venous-thrombosis-and-pulmonary-embolism-in-primary-sj%C3%A3-gren-syndrome-a-general-population-based-study
#12
J Antonio Aviña-Zubieta, Michael Jansz, Eric C Sayre, Hyon K Choi
OBJECTIVE: To estimate the future risk and time trends of venous thromboembolism (VTE) in individuals with newly diagnosed primary Sjögren syndrome (pSS) in the general population. METHODS: Using a population database that includes all residents of British Columbia, Canada, we created a study cohort of all patients with incident SS and up to 10 controls from the general population matched for age, sex, and entry time. We compared incidence rates (IR) of pulmonary embolism (PE), deep vein thrombosis (DVT), and VTE between the 2 groups according to SS disease duration...
August 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28275260/beyond-tnf-tnf-superfamily-cytokines-as-targets-for-the-treatment-of-rheumatic-diseases
#13
REVIEW
Michael Croft, Richard M Siegel
TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis, and also in nonrheumatic syndromes such as inflammatory bowel disease. As TNF belongs to a superfamily of 19 structurally related proteins that have both proinflammatory and anti-inflammatory activity, reagents that disrupt the interaction between proinflammatory TNF family cytokines and their receptors, or agonize the anti-inflammatory receptors, are being considered for the treatment of rheumatic diseases...
April 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/22717204/evanescent-and-persistent-pruritic-eruptions-of-adult-onset-still-disease-a-clinical-and-pathologic-study-of-36-patients
#14
Julia Yu-Yun Lee, Chao-Kai Hsu, Ming-Fei Liu, Sheau-Chiou Chao
OBJECTIVE: Persistent pruritic eruptions (PPE) are common among our patients with adult-onset Still disease (AOSD). We aimed to characterize the clinicopathologic features of the AOSD-associated evanescent and persistent rashes. METHODS: We reviewed the clinicopathologic features of the skin lesions from all AOSD cases diagnosed in our hospital during 1988 to 2009. The diagnoses were based on Yamaguchi criteria for AOSD. RESULTS: Altogether, there were 36 patients (6 men and 30 women) with age of onset ranging from 17 to 67 years (average 35...
December 2012: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/24628100/persistent-pruritic-papules-and-plaques-associated-with-adult-onset-still-s-disease-report-of-six-cases
#15
Nobuyuki Kikuchi, Masataka Satoh, Mikio Ohtsuka, Toshiyuki Yamamoto
Typical skin rash, which appears and disappears along with respective rise and fall of fever, is well-known, and included as one of the major criteria of adult-onset Still's disease (AOSD) (Yamaguchi's criteria). In addition, various skin lesions are occasionally observed in association with AOSD. Persistent pruritic eruptions present with some clinical features, such as urticarial erythema, flagellate erythema, erythematous, slightly scaly or crusted papules, and/or plaques on the trunk and extremities. These lesions show unique histological features such as dyskeratosis with a peculiar, distinctive distribution in the upper epidermis and cornified layers with focal hyperkeratosis...
May 2014: Journal of Dermatology
https://www.readbyqxmd.com/read/22198666/cutaneous-manifestations-associated-with-adult-onset-still-s-disease-important-diagnostic-values
#16
Toshiyuki Yamamoto
Adult-onset Still's disease (AOSD) is a systemic inflammatory condition, characterized by a high spiking fever, leukocytosis with neutrophilia, arthralgia, and skin rash. Typical skin rash is an evanescent, salmon-pink erythema predominantly involving extremities, which is included as one of the diagnostic criteria; however, recent findings show that not only typical evanescent rash but also various skin lesions are associated with AOSD. The representative characteristic skin lesion among the non-classical skin rash is called persistent pruritic papules and plaques, which presents erythematous, slightly scaly papules with linear configuration on the trunk...
August 2012: Rheumatology International
https://www.readbyqxmd.com/read/21918897/mycoplasma-pneumoniae-infection-associated-with-urticarial-vasculitis-mimicking-adult-onset-still-s-disease
#17
Janet Dua, Anupama Nandagudi, Nurhan Sutcliffe
Mycoplasma pneumoniae is well known to be a frequent cause of atypical pneumonia worldwide. However, it may also present with a wide variety of clinical features, including cutaneous symptoms, which are not widely recognised. Urticarial vasculitis occurring with M. pneumoniae has been described to occur in only one other case report. This amalgamation of non-specific clinical symptoms and signs can lead to a diagnostic dilemma. We describe a case of M. pneumoniae infection presenting with extrapulmonary manifestations and urticarial vasculitis, which was misdiagnosed as adult-onset Still's disease (AOSD)...
December 2012: Rheumatology International
https://www.readbyqxmd.com/read/24737284/cutaneous-manifestations-of-adult-onset-still-s-disease-a-case-report-and-review-of-literature
#18
REVIEW
Alessandra Cozzi, Anastasia Papagrigoraki, Domenico Biasi, Chiara Colato, Giampiero Girolomoni
Adult onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology and pathogenesis characterized by high spiking fever, arthralgia or arthritis, sore throat, lymphadenopathy, hepatosplenomegaly, serositis, and transient cutaneous manifestations. Although more common in children, cases are seen also in adults. Cutaneous involvement is common and may be suggestive for the diagnosis. A case of AOSD in a 35-year-old man is reported here, presenting with urticarial maculopapular rash of trunk, high spiking fever, acute respiratory distress syndrome, and myopericarditis...
May 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/26054431/updates-in-adult-onset-still-disease-atypical-cutaneous-manifestations-and-associations-with-delayed-malignancy
#19
REVIEW
Natalie Z Sun, Elizabeth A Brezinski, Jacqueline Berliner, Anna Haemel, M Kari Connolly, Lianne Gensler, Timothy H McCalmont, Kanade Shinkai
Adult-onset Still disease (AOSD) is a systemic inflammatory disorder that is clinically characterized by a heterogeneous constellation of symptoms and signs. Though an evanescent eruption is the classic cutaneous finding, recent literature has highlighted atypical rashes associated with Still disease. A second emerging concept in presentations of AOSD is its association with malignancy. This review focuses on these concepts: the clinical spectrum of atypical skin manifestations and AOSD as a paraneoplastic phenomenon...
August 2015: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27431346/genetics-in-sj%C3%A3-gren-syndrome
#20
REVIEW
Tove Ragna Reksten, Christopher J Lessard, Kathy L Sivils
The genes associated with Sjögren syndrome (SS) can be assigned to the NF-kB pathway, the IFN signaling pathway, lymphocyte signaling, and antigen presentation. The frequencies of risk variants show they are common with modest genetic effects. The strongest genetic association outside the human leukocyte antigen region is in IRF5, a gene relevant in the IFN signaling pathway and for B cell differentiation. Although no association has been found with the NF-kB gene itself, associations in TNFAIP3 and TNIP1 (both genome-wide significant), VCAM1 and IRAK1BP (both suggestive), point to genetic explanations for dysregulation of the NF-kB pathway in SS...
August 2016: Rheumatic Diseases Clinics of North America
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