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By Wei No
https://www.readbyqxmd.com/read/26162302/anti-ssa-ssb-negative-sj%C3%A3-gren-s-syndrome-shows-a-lower-prevalence-of-lymphoproliferative-manifestations-and-a-lower-risk-of-lymphoma-evolution
#1
REVIEW
Luca Quartuccio, Chiara Baldini, Elena Bartoloni, Roberta Priori, Francesco Carubbi, Laura Corazza, Alessia Alunno, Serena Colafrancesco, Nicoletta Luciano, Roberto Giacomelli, Roberto Gerli, Guido Valesini, Stefano Bombardieri, Salvatore De Vita
OBJECTIVE: This study aims to compare clinical and laboratory features of patients who, while satisfying the American European Consensus Group (AECG) criteria for primary Sjögren's syndrome (SS), do not present the positivity for anti-Ro/SSA and/or anti-La/SSB, with patients that meet the AECG criteria and are positive for anti-Ro/SSA and/or anti-La/SSB. METHODS: 548 patients were selected based on the following criteria, and exclusion of patients negative for histopathology but positive for anti-Ro/SSA and anti-La/SSB: 1...
November 2015: Autoimmunity Reviews
https://www.readbyqxmd.com/read/24333103/a-comprehensive-review-of-autoantibodies-in-primary-sj%C3%A3-gren-s-syndrome-clinical-phenotypes-and-regulatory-mechanisms
#2
REVIEW
Nikolaos C Kyriakidis, Efstathia K Kapsogeorgou, Athanasios G Tzioufas
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by periepithelial lymphocytic infiltrates in affected tissues and the production of plethora of autoantibodies. Among them autoimmune responses against Ro/SSA and La/SSB are of major importance since their detection is routinely used for disease diagnosis and clinical characterization. Although the exact mechanisms underlying disease pathogenesis are not fully understood, the important role of salivary gland epithelial cells (SGEC) in the initiation and development of the local immune responses is well-established...
June 2014: Journal of Autoimmunity
https://www.readbyqxmd.com/read/25735642/the-ssb-positive-ssa-negative-antibody-profile-is-not-associated-with-key-phenotypic-features-of-sj%C3%A3-gren-s-syndrome
#3
Alan N Baer, Mara McAdams DeMarco, Stephen C Shiboski, Mi Y Lam, Stephen Challacombe, Troy E Daniels, Yi Dong, John S Greenspan, Bruce W Kirkham, Hector E Lanfranchi, Morten Schiødt, Muthiah Srinivasan, Hisanori Umehara, Frederick B Vivino, Cristina F Vollenweider, Yan Zhao, Lindsey A Criswell, Caroline H Shiboski
OBJECTIVE: To determine whether the Sjögren's syndrome B (SSB)-positive/Sjögren's syndrome A (SSA)-negative antibody profile is associated with key phenotypic features of SS. METHODS: Among registrants in the Sjögren's International Collaborative Clinical Alliance (SICCA) with possible or established SS, we compared anti-SSA/anti-SSB reactivity profiles against concurrent phenotypic features. We fitted logistic regression models to explore the association between anti-SSA/anti-SSB reactivity profile and each key SS phenotypic feature, controlling for potential confounders...
August 2015: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28122959/type-i-interferon-mediated-autoimmune-diseases-pathogenesis-diagnosis-and-targeted-therapy
#4
Antonios Psarras, Paul Emery, Edward M Vital
Type I interferons (IFN-Is) are a group of molecules with pleiotropic effects on the immune system forming a crucial link between innate and adaptive immune responses. Apart from their important role in antiviral immunity, IFN-Is are increasingly recognized as key players in autoimmune CTDs such as SLE. Novel therapies that target IFN-I appear effective in SLE in early trials, but effectiveness is related to the presence of IFN-I biomarkers. IFN-I biomarkers may also act as positive or negative predictors of response to other biologics...
January 24, 2017: Rheumatology
https://www.readbyqxmd.com/read/28138822/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-and-the-rheumatologist
#5
REVIEW
Marwan H Adwan
PURPOSE OF THE REVIEW: The purpose of the review is to summarise the various drugs used in rheumatology practice implicated in the causation of DRESS syndrome. RECENT FINDINGS: The most commonly reported drugs are allopurinol, sulfasalazine and minocycline, which pose a very high risk for DRESS syndrome development, followed by strontium ranelate and dapsone. Other, less commonly reported, drugs include leflunomide, hydroxychloroquine, non-steroidal anti-inflammatory drugs, febuxostat, bosentan and solcitinib...
January 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/26970491/autoantibodies-in-inflammatory-arthritis
#6
REVIEW
P Conigliaro, M S Chimenti, P Triggianese, F Sunzini, L Novelli, C Perricone, R Perricone
Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterized by extensive synovitis resulting in erosions of articular cartilage and marginal bone with joint destruction. The lack of immunological tolerance in RA represents the first step toward the development of autoimmunity. Susceptible individuals, under the influence of environmental factors, such as tobacco smoke, and silica exposure, develop autoimmune phenomena that result in the presence of autoantibodies. HLA and non-HLA haplotypes play a major role in determining the development of specific autoantibodies differentiating anti-citrullinated antibodies (ACPA)-positive and negative RA patients...
July 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28138914/obstetric-and-perinatal-outcome-in-anti-ro-ssa-positive-pregnant-women-a-prospective-cohort-study
#7
Nuria Martínez-Sánchez, Sergio Pérez-Pinto, Ángel Robles-Marhuenda, Francisco Arnalich-Fernández, María Martín Cameán, Edurne Hueso Zalvide, Jose Luis Bartha
: Anti-Ro/SS-A is one specific type of antinuclear antibodies. They are in the majority of cases associated with primary Sjögren syndrome (SS) but also in Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA), and in healthy people. During pregnancy, they are mainly associated to congenital heart block (CHB) and neonatal lupus (NL). The aim of this study was to compare the rate of maternal and fetal complications between a series of anti-Ro/SS-A positive pregnant women prospectively followed...
January 30, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28142222/flagellar-filament-structural-protein-induces-sj%C3%A3-gren-s-syndrome-like-sialadenitis-in-mice
#8
Tomoaki Higuchi, Ikuko Haruta, Noriyuki Shibata, Naoko Yanagisawa, Junji Yagi
OBJECTIVE: Sjögren's syndrome (SS) is a systemic autoimmune disease that primarily affects lacrimal and salivary glands. We previously reported that FliC derived from E. coli could induce autoimmune pancreatitis-like lesions. From these results, we speculated that FliC could also induce SS-like exocrinopathy. In the present study, we investigated the effects of chronic exposure to FliC on lacrimal and salivary glands and the possibility that it might lead to an autoimmune response. METHODS: C57BL/6 mice were repeatedly injected with FliC and histological changes, serum levels of cytokine/chemokines and autoantibodies were evaluated at different time points after the final injection...
January 31, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28147328/autoantibody-to-mdm2-a-potential-serological-marker-of-primary-sjogren-s-syndrome
#9
Yuan Liu, Xining Liao, Ying Wang, Shiju Chen, Yuechi Sun, Qingyan Lin, Guixiu Shi
INTRODUCTION: Primary Sjogren's Syndrome (pSS) is one of the autoimmune diseases characterized by polyclonal autoantibody production. The human homologue of the mouse double minute 2 (MDM2) is an important negative regulator of p53. Our previous study indicated that autoantibody to MDM2 can be detected in systemic lupus erythematosus patients. The purpose of this study is to study anti-MDM2 autoantibody in pSS patients. METHODS: Anti-MDM2 autoantibody in sera from 100 pSS patients and 74 normal controls was investigated by ELISA...
January 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28141917/enhanced-bruton-s-tyrosine-kinase-activity-in-peripheral-blood-b-lymphocytes-of-autoimmune-disease-patients
#10
Odilia B J Corneth, Gwenny M P Verstappen, Sandra M J Paulissen, Marjolein J W de Bruijn, Jasper Rip, Melanie Lukkes, Jan Piet van Hamburg, Erik Lubberts, Hendrika Bootsma, Frans G M Kroese, And Rudi W Hendriks
OBJECTIVE: Bruton's tyrosine kinase (BTK) transmits crucial survival signals from the B cell receptor (BCR) in B cells. Pharmacological BTK inhibition effectively diminishes disease symptoms in mouse models of autoimmunity and, conversely, transgenic BTK overexpression induces systemic autoimmunity in mice. We investigated BTK expression and activity in human B cells in the context of autoimmune disease. METHODS: Using intracellular flow cytometry, we quantified BTK expression and phosphorylation in peripheral blood B cell subsets in patients with rheumatoid arthritis (RA; n=30) and primary Sjogren's Syndrome (pSS; n=26) and matched healthy controls...
January 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28150582/one-year-in-review-2016-spondyloarthritis
#11
REVIEW
Alice Parma, Laura Cometi, Maria Comasia Leone, Gemma Lepri, Rosaria Talarico, Serena Guiducci
Spondyloarthritis represents a heterogeneous group of articular inflammatory diseases that share common genetic, clinical and radiological features. Recently, novel insights into the epidemiology, pathogenesis and treatment of these diseases have been provided. Herewith, we present an overview ofthe most significant literature contributions published over the past year.
January 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27965259/standardisation-of-labial-salivary-gland-histopathology-in-clinical-trials-in-primary-sj%C3%A3-gren-s-syndrome
#12
Benjamin A Fisher, Roland Jonsson, Troy Daniels, Michele Bombardieri, Rachel M Brown, Peter Morgan, Stefano Bombardieri, Wan-Fai Ng, Athanasios G Tzioufas, Claudio Vitali, Pepe Shirlaw, Erlin Haacke, Sebastian Costa, Hendrika Bootsma, Valerie Devauchelle-Pensec, Timothy R Radstake, Xavier Mariette, Andrea Richards, Rebecca Stack, Simon J Bowman, Francesca Barone
Labial salivary gland (LSG) biopsy is used in the classification of primary Sjögren's syndrome (PSS) and in patient stratification in clinical trials. It may also function as a biomarker. The acquisition of tissue and histological interpretation is variable and needs to be standardised for use in clinical trials. A modified European League Against Rheumatism consensus guideline development strategy was used. The steering committee of the ad hoc working group identified key outstanding points of variability in LSG acquisition and analysis...
December 13, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28124217/elemental-analysis-of-whole-and-protein-separated-blood-serum-of-patients-with-systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome
#13
Csilla Noémi Tóth, Edina Baranyai, István Csípő, Tünde Tarr, Margit Zeher, József Posta, István Fábián
Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) are systemic autoimmune diseases with complex symptoms and pathogenesis that are still not completely understood. Several studies showed that the trace element homeostasis and also the levels of antioxidant plasma proteins are changed in autoimmune disorders; however, these results are controversial. In this study, the potassium (K), calcium (Ca), magnesium (Mg), copper (Cu), zinc (Zn), and iron (Fe) concentrations of the serum and proteins-immunoglobulin G (IgG), transferrin (Trf), albumin (Alb), and ceruloplasmin (Cp)-separated from serum samples by affinity chromatography were determined in patients with SLE and SS...
January 26, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28124612/unique-phenotypes-and-functions-of-follicular-helper-t-cell-and-regulatory-t-cell-in-sj%C3%A3-gren-s-syndrome
#14
Masako Saito, Kunihiro Otsuka, Aya Ushio, Akiko Yamada, Rieko Arakaki, Yasusei Kudo, Naozumi Ishimaru
Sjögren's syndrome (SS) is a T cell-mediated autoimmune disease of the systemic exocrine glands, such as salivary and lacrimal glands. A variety of T-cell subpopulations maintain immune tolerance in the thymus and periphery through complex immune responses including cellular and humoral immunity. The T-cell subpopulations exhibiting abnormal or unique phenotypes and impaired functionality have been reported to play important roles in the cellular mechanisms of autoimmunity in SS patients and animal models of SS...
January 25, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28127640/ten-year-progression-of-coronary-artery-carotid-artery-and-aortic-calcification-in-patients-with-rheumatoid-arthritis
#15
Ju-Hua Liu, Ming-Yen Ng, Tommy Cheung, Ho-Yin Chung, Yan Chen, Zhe Zhen, Yuan Zou, Ka-Fung Mak, Pek-Lan Khong, Chak-Sing Lau, Hung-Fat Tse, Kai-Hang Yiu
Rheumatoid arthritis (RA) is associated with increased vascular calcification, although the rate of progress of calcification is uncertain. The aim of the study was to evaluate the progression of and the predictors for calcification in different vascular beds over 10 years. The 10-year actual coronary calcium score (CS) and 10-year predicted coronary CS, based on the pattern of the general population, were compared. Calcification of the coronary and carotid artery and the aorta was assessed by multi-detector computed tomography...
January 26, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28099084/mechanisms-and-new-strategies-for-primary-sj%C3%A3-gren-s-syndrome
#16
Clio P Mavragani
Primary Sjögren's syndrome (SS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, mainly salivary and lacrimal, resulting in oral and ocular dryness, although virtually any organ system can be affected. SS-related systemic manifestations are classified as either related to the presence of periepithelial infiltrates in exocrine and parenchymal organs or resulting from immunocomplex deposition due to B cell hyperactivity with increased risk for B cell lymphoma development...
January 14, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/28094760/treat-to-target-biologic-therapy-in-patients-with-rheumatoid-arthritis-is-more-efficacious-and-safe-compared-to-delayed-initiation-of-biologics-a-real-world-study
#17
Christos E Lampropoulos, Philippos Orfanos, Menelaos N Manoussakis, Athanasios G Tzioufas, Haralampos M Moutsopoulos, Panayiotis G Vlachoyiannopoulos
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic, devastating disease. Treat-to-target strategy (T2T) more than the usual care, reduces disease activity by using aggressively all therapeutic options. The aim of the study was to evaluate our hypothesis that T2T strategy using biologic disease-modifying anti-rheumatic drugs (bDMARDs), when needed, is also safer than the usual care characterised by delayed initiation of bDMARDs. METHODS: Disease activity was regularly measured by DAS-28 until the end of treatment with the first bDMARD...
January 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28062405/presence-of-multiple-spondyloarthritis-spa-features-is-important-but-not-sufficient-for-a-diagnosis-of-axial-spondyloarthritis-data-from-the-spondyloarthritis-caught-early-space-cohort
#18
Z Ez-Zaitouni, P A C Bakker, M van Lunteren, I J Berg, R Landewé, M van Oosterhout, M Lorenzin, D van der Heijde, F A van Gaalen
OBJECTIVES: Concerns have been raised about overdiagnosis of axial spondyloarthritis (axSpA). We investigated whether patients with chronic back pain (CBP) of short duration and multiple SpA features are always diagnosed with axSpA by the rheumatologist, and to what extent fulfilment of the Assessment of SpondyloArthritis International Society (ASAS) axSpA criteria is associated with an axSpA diagnosis. METHODS: Baseline data from 500 patients from the SPondyloArthritis Caught Early cohort which includes patients with CBP (≥3 months, ≤2 years, onset <45 years) were analysed...
January 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28100423/osteoarthritis-year-in-review-2016-clinical
#19
REVIEW
N E Lane, K Shidara, B L Wise
Both epidemiologic and clinical research continues to be performed in osteoarthritis (OA). While epidemiologic studies identify risk factors for incident and progressive disease, clinical studies explore the role of both non-pharmacologic and pharmacologic treatments, including oral and intra-articular therapies. We performed a systematic review of the literature using PubMed for the time period between April 1, 2015 to February 22, 2016. Selected publications in the areas of both epidemiology and treatment are reviewed in this article...
December 20, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27988431/clinical-utility-of-circulating-anti-n-methyl-d-aspartate-receptor-subunits-nr2a-b-antibody-for-the-diagnosis-of-neuropsychiatric-syndromes-in-systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome-an-updated-meta-analysis
#20
REVIEW
Sen Hee Tay, Anna-Marie Fairhurst, Anselm Mak
BACKGROUND/PURPOSE: Neuropsychiatric (NP) events are found in patients with rheumatic diseases, commonly in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). The standard nomenclature and case definitions for 19 NPSLE syndromes by the American College of Rheumatology (ACR) Committee on Research cover a wide range of NP events seen in both SLE and SS. Despite advances in the understanding of SLE and SS, NP syndromes continue to pose diagnostic challenges. Correct attribution of NP events is critical in determining the correct treatment and prognosis...
February 2017: Autoimmunity Reviews
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